Category: 2150-55-2

Weuffen, W.; Jess, G.; Juelich, W. D.; Bernhardt, D. published an article about the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2,SMILESS:O=C(C1N=C(N)SC1)O ).COA of Formula: C4H6N2O2S. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2150-55-2) through the article.

In vitro and in vivo experiments have been carried out to elucidate the metabolism of 2-iminothiazolidine-4-carboxylic acid (I) [2150-55-2]. By using I-35S, the formation. of 35SCN as well as of 35S-containing I metabolites could be excluded. As compared to the findings from control animals, the serum SCN levels determined in guinea pigs after oral administration of I were unchanged.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Review, Forensic science review called The potential use of 2-aminothiazoline-4-carboxylic acid (ATCA) as a forensic marker for cyanide exposure in medicolegal death investigation: A review., Author is Li, S Y; Petrikovics, I; Yu, J, which mentions a compound: 2150-55-2, SMILESS is O=C(C1N=C(N)SC1)O, Molecular C4H6N2O2S, Category: pyrazines.

Cyanide (CN) is one of the most toxic of all substances and can be found in various natural and anthropogenic sources. Sensitive and effective methods for the confirmation of CN exposure are crucial in medical, military, and forensic settings. Due to its high volatility and reactivity, direct detection of CN from postmortem samples could raise inconclusive interpretation issues that may hinder accurate determination of the cause of death. The detection of the alternative CN metabolites as markers to test CN exposure may offer a solution to reduce the potential for false-negative and false-positive results. 2-Aminothiazoline-4-carboxylic acid (ATCA) is a minor metabolite of CN and has been proposed to be a potential alternative forensic marker for the confirmation of CN exposure. According to the current state of knowledge, ATCA has not yet been associated with other metabolic pathways except for CN detoxification. Moreover, ATCA is stable under various conditions over time. This article reviews analytical methods developed for the analysis of ATCA as well as studies related to potential use of ATCA as a marker for the diagnosis of CN exposure. The need for research related to the use of ATCA as a reliable forensic marker for CN exposure in medicolegal death investigations is also discussed.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yamamoto, Yasushi; Fujita, Itsuo; Horino, Issei; Kouda, Tohru; Akashi, Kunihiko researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Recommanded Product: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.They published the article 《Enzymatic production of cystine in commercial plant》 about this compound( cas:2150-55-2 ) in Nippon Nogei Kagaku Kaishi. Keywords: cystine enzymic manufacture hydrogen sulfide removal; iron removal chelating cysteine manufacture enzymic. We’ll tell you more about this compound (cas:2150-55-2).

For the enzymic production of cystine in a com. plant, the improvement of reaction process, the purification procedure, and the removal process of hydrogen sulfide were studied. Fed-batch process was adapted to the enzymic reaction and optimized. In the purification process, contaminating Fe ion was excluded from cystine products by adding chelating agent and the co-produced hydrogen sulfide was removed by an oxidation method. An improved process was realized in the industrial plant.

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Recommanded Product: 2150-55-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Toxicokinetic profiles of α-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide. Author is Mitchell, Brendan L.; Bhandari, Raj K.; Bebarta, Vikhyat S.; Rockwood, Gary A.; Boss, Gerry R.; Logue, Brian A..

Poisoning by cyanide can be verified by anal. of the cyanide detoxification product, α-ketoglutarate cyanohydrin (α-KgCN), which is produced from the reaction of cyanide and endogenous α-ketoglutarate. Although α-KgCN can potentially be used to verify cyanide exposure, limited toxicokinetic data in cyanide-poisoned animals are available. The authors, therefore, studied the toxicokinetics of α-KgCN and compared its behavior to other cyanide metabolites, thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid (ATCA), in the plasma of 31 Yorkshire pigs that received KCN (4 mg/mL) i.v. (IV) (0.17 mg/kg/min). α-KgCN concentrations rose rapidly during KCN administration until the onset of apnea, and then decreased over time in all groups with a half-life of 15 min. The maximum concentrations of α-KgCN and cyanide were 2.35 and 30.18 μM, resp., suggesting that only a small fraction of the administered cyanide is converted to α-KgCN. Although this is the case, the α-KgCN concentration increased >100-fold over endogenous concentrations compared to only a three-fold increase for cyanide and ATCA. The plasma profile of α-KgCN was similar to that of cyanide, ATCA, and thiocyanate. The results of this study suggest that the use of α-KgCN as a biomarker for cyanide exposure is best suited immediately following exposure for instances of acute, high-dose cyanide poisoning.

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Recommanded Product: 2150-55-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Microbial conversion mechanism of D,L-2-amino-Δ2-thiazoline-4-carboxylic acid to L-cysteine in Pseudomonas species and its application. Author is Ohmachi, Tetsuo.

A review. L-Cysteine which is widely used in food additives, nutritional infusions, and cosmetics and medicines has mainly been produced from hydrolyzates of hair by acid or alkali. As an alternative to this traditional method, a new microbial conversion method for L-cysteine production from a chem. synthesized precursor, D,L-2-amino-Δ2-thiazoline-4-carboxylic acid (D,L-ATC), using Pseudomonas species was developed. From the studies on the microbial conversion process of D,L-ATC to L-cysteine in several Pseudomonas strains by several groups, it was found that there are two pathways via S-carbamoyl-L-cysteine (L-SCC, pathway 1) and via N-carbamoyl-L-cysteine (L-NCC, pathway 2) in the microbial conversion process. We isolated and identified the genes for ATC hydrolase and NCC amidohydrolase, which are involved in pathway 2 in Pseudomonas sp. ON-4a. The ATC hydrolase and NCC amidohydrolase expressed in Escherichia coli were purified and characterized. In this study, we clarified the mol. basis of the microbial conversion of D,L-ATC to L-cysteine. We propose that L-cysteine production from D,L-ATC can be effectively carried out by two continuous reactions using recombinant ATC hydrolase and NCC amidohydrolase.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Formation of 2-iminothiazolidine-4-carboxylic acid in the cyanobromination of lanthionine, published in 1963, which mentions a compound: 2150-55-2, Name is 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, Molecular C4H6N2O2S, Related Products of 2150-55-2.

A 5 ml. solution of lanthionine in 0.1N HCl was added to 5 ml. 5% aqueous NaCN and the mixture treated with 1 ml. NCBr solution (prepared by adding 5% aqueous NaCN to a saturated solution of Br till the solution was just colorless). After 3 consecutive boilings for 30 secs. and cooling for 3 min., the thiol content estimation was interfered with by incomplete removal of NCBr. The reaction mixture was, therefore, boiled for 10 min., but the quantity of thiol formed was not consistent and reproducibility of the results was very poor. Paper chromatography of the products in sec-BuOH-HCOOH-H2O (75:15:10) system showed the presence of 2-iminothiazolidine-4-carboxylic acid (I). In these experiments, HCl was converted to HCN, which was expelled on boiling and probably the high pH led to the formation of the acid.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Identification of bioconversion product from DL-ATC and optimization of reaction conditions in Pseudomonas sp. F12, the main research direction is Pseudomonas cysteine desulfhydrase bioconversion hydrogen sulfide.Product Details of 2150-55-2.

The objective if this work was to identify the bioconversion product from DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) and enhance L-cysteine yield from it. Reaction mixture was analyzed by HPLC and LC-MS; comparison among different reaction conditions of L-cysteine decomposition was performed. Contrast to standard L-cysteine, the results of HPLC and LC-MS indicated that it was L-cysteine; a small amount of hydrogen sulfide produced from degradation of L-cysteine inhibited L-cysteine desulfhydrase dramaticly in air-free condition which contributed the highest amount of L-cysteine arrived 46.2 mmol/L with a yield of 94%, in contrast to that of 31.6% under initial condition. Pseudomonas sp. F12 equipped with the ability of converting DL-ATC to L-cysteine; it was beneficial for L-cysteine accumulation in air-free condition.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Simultaneous oxidative reaction crystallization of L-cystine from L-cysteine with enzyme reactions from DL-amino-thiazoline-carboxylic acid, the main research direction is oxidative reaction crystallization cystine enzyme oxygen.Application In Synthesis of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.

A novel system for oxidative reaction crystallization of L-cystine (CySSCy) from L-cysteine (CySH) obtained by simultaneous enzyme reaction was studied. L-cysteine was produced from DL-amino-thiazoline-carboxylic acid (ATC) by enzymes in the same cell grown beforehand. Generally, the processes involving oxidation after enzyme reactions are time consuming and yield small size CySSCy crystals. In the present investigation oxygen was fed simultaneously along with the enzyme reaction in such a way that it was matched both with the production and oxidation rates of CySH yielding CySSCy at an optimum rate, thus minimizing the level of dissolved oxygen which suppresses the activities of the oxygen-sensitive enzymes. As a result, the overall reaction time was reduced and large size CySSCy crystals were obtained, while improving the enzyme reaction yield.

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Computed Properties of C4H6N2O2S. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Genes from Pseudomonas sp. strain BS involved in the conversion of L-2-amino-Δ2-thiazolin-4-carbonic acid to L-cysteine. Author is Shiba, Toshikazu; Takeda, Kohji; Yajima, Misako; Tadano, Makoto.

DL-2-Amino-Δ2-thiazoline-4-carbonic acid (DL-ATC) is a substrate for cysteine synthesis in some bacteria, and this bioconversion has been utilized for cysteine production in industry. We cloned a DNA fragment containing the genes involved in the conversion of L-ATC to L-cysteine from Pseudomonas sp. strain BS. The introduction of this DNA fragment into Escherichia coli cells enabled them to convert L-ATC to cysteine via N-carbamoyl-L-cysteine (L-NCC) as an intermediate. The smallest recombinant plasmid, designated pTK10, contained a 2.6-kb insert DNA fragment that has L-cysteine synthetic activity. The nucleotide sequence of the insert DNA revealed that two open reading frames (ORFs) encoding proteins with mol. masses of 19.5 and 44.7 kDa were involved in the L-cysteine synthesis from DL-ATC. These ORFs were designated atcB and atcC, resp., and their gene products were identified by overproduction of proteins encoded in each ORF and by the maxicell method. The functions of these gene products were examined using extracts of E. coli cells carrying deletion derivatives of pTK10. The results indicate that atcB and atcC are involved in the conversion of L-ATC to L-NCC and the conversion of L-NCC to cysteine, resp. AtcB was first identified as a gene encoding an enzyme that catalyzes thiazoline ring opening. AtcC is highly homologous with L-N-carbamoylases. Since both enzymes can only catalyze the L-specific conversion from L-ATC to L-NCC or L-NCC to L-cysteine, it is thought that atcB and atcC encode L-ATC hydrolase and N-carbamoyl-L-cysteine amidohydrolase, resp.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Microbial conversion of DL-2-amino-Δ-thiazoline-4-carboxylic acid to L-cysteine and L-cystine: screening of microorganisms and identification of products.Application of 2150-55-2.

Microorganisms able to form L-cysteine from DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC), an intermediate in the chem. synthesis of DL-cysteine, were isolated from soil samples and classified as Pseudomonas AJ3854, Pseudomonas cohaerens, P. desmolytica, and P. ovalis. Thirteen L-cysteine-producing bacteria were also found among 463 stock cultures representing 37 genera. Intact cells of Pseudomonas AJ 3854 produced 6.1 mg of L-cysteine and(or) L-cystine per mL from 10 mg of DL-ATC.3H2O per mL, a molar yield of 100%. This suggests that racemization and asym. hydrolysis occurred simultaneously in this incubation mixture After complete oxidation of cysteine, crystalline cystine was isolated; its configuration was L, based on data from x-ray diffraction, microbioassay, and optical rotation.

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