Category: 213019-67-1

Adding a certain compound to certain chemical reactions, such as: 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 213019-67-1, Product Details of 213019-67-1

A solution of bromine in dichloromethane (10ml) was added in portions to a stirred solution of 2-amino-3-trifluoromethylpyrazine (1.5g, 9.2mmol) and pyridine (0.90ml, 1 1 mmol) in chloroform. The resulting mixture was stirred at room temperature for 24 hours. Volatiles were removed under reduced pressure and the residue was purified by chromatography on silica gel using a gradient of ethyl acetate in isohexane as eluent to give 2-amino-3-trifluoromethyl-5-bromopyrazine (1 .7g, 77%) as an off-white solid. (0286) 1H NMR (400MHz, CDCI3) delta 8.30 (s, 1 H), 5.13 (br s, 2H).

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Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WAILES, Jeffrey, Steven; CARTER, Neil, Brian; CLOUGH, John, Martin; WILLIAMS, John; (57 pag.)WO2019/57723; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., name: 3-(Trifluoromethyl)pyrazin-2-amine

To 3-(trifluoromethyl)pyrazin-2-amine (0.020 g, 0.12 mmol, Oakwood) in CH2Cl2 (0.5 mL) was added N-bromosuccinimide (0.022 g, 0.12 mmol) and the reaction was stirred overnight. The reaction mixture was partitioned between DCM and water, and the aqueous portion was extracted with three portions of DCM. The combined organic extracts were dried over Na2SO4, filtered, and concentrated. The product was purified by flash chromatography, eluting with a gradient from 0-25% EtOAc in hexanes to afford a white crystalline solid (0.013 g, 44%). 1H NMR (400 MHz, CDCl3) delta 8.44-8.23 (s, 1H), 5.22-4.98 (s, 2H). 19F NMR (376 MHz, CDCl3) delta -65.04–69.69 (s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 213019-67-1.

Reference:
Patent; Incyte Corporation; Shepard, Stacey; Combs, Andrew P.; Falahatpisheh, Nikoo; Shao, Lixin; (96 pag.)US2019/276435; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, A new synthetic method of this compound is introduced below., Product Details of 213019-67-1

[1388] A solution of 3-(trifluoromethyl)pyrazin-2-amine (0.075 g, 0.460 mmol) [Oakwood, 500509] in dichloromethane (1.88 mL) was treated with N-bromosuccinimide (0.082 g, 0.460 mmol) and stirred at rt for 15 h. The reaction mixture was treated with additional N-bromosuccinimide (0.041 g, 0.230 mmol) and stirred for 21 h. The reaction mixture was diluted with water (10 mL) and extracted with dichloromethane (220 mL). The combined organic extracts were dried over sodium sulfate, filtered, and concentrated to brown, oily-solid. Purification by flash column chromatography using EtOAc in hexanes (0% to 30%) gave the desired product (64.5 mg, 58.1%) as a white solid. LCMS for C5H4BrF3N3(M+H)+: m/z=242.0, 243.9; Found: 241.9, 243.9.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Incyte Corporation; Douty, Brent; Ai, Yanran; Burns, David M.; Combs, Andrew P.; Falahatpisheh, Nikoo; Levy, Daniel; Polam, Padmaja; Shao, Lixin; Shepard, Stacey; Shvartsbart, Artem; Yue, Eddy W.; (132 pag.)US2020/2295; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, molecular formula is C5H4F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3-(Trifluoromethyl)pyrazin-2-amine

N-lodosuccinimide (3.4g, 15mmol) was added to a stirred suspension of 2-amino-3- trifluoromethylpyrazine (1 .63g, 10mmol) and trifluoroacetic acid (340mg, 3mmol) in acetonitrile (20ml) at room temperature. After stirring at room temperature for another 18 hours, the mixture was filtered. The filtrate was diluted with ethyl acetate and washed with a saturated aqueous solution of sodium thiosulfate. The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate = 5:1 as eluent to give 2-amino-3-trifluoromethyl-5-iodopyrazine (1.27g, 44%) as a yellow solid. (0278) 1H NMR (300Mz, DMSO-d6): delta 8.48 (s, 1 H), 7.06 (br s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 213019-67-1, its application will become more common.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WAILES, Jeffrey, Steven; CARTER, Neil, Brian; CLOUGH, John, Martin; WILLIAMS, John; (57 pag.)WO2019/57723; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H4F3N3

A solution of bromine in dichloromethane (1 OmI) was added in portions to a stirred solution of 2-amino-3-trifluoromethylpyrazine (1 .5g, 9.2mmol) and pyridine (0.90m1, limmol) in chloroform. The resulting mixture was stirred at room temperature for 24hours. Volatiles were removed under reduced pressure and the residue was purified by chromatography on silica gel using a gradient of ethyl acetate in isohexane as eluent to give 2-am ino-3-trifluoromethyl-5-bromopyrazine (1 .7g, 77% yield) as an off-white solid.1H NMR (400 MHz, CDCI3)5 8.30 (s, 1H), 5.13 (br s, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 213019-67-1.