Category: 21279-64-1

Application of 21279-64-1, These common heterocyclic compound, 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3.3 2 -[[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]amino]pyrazine-5-carboxamide (E)-but-2-enedioate 5.7 g (0.0242 mol) of 2-[4-(2-methoxyphenyl)-piperazin-1-yl]ethanamine, 3.82 g (0. 0242 mol) of 2-chloropyrazine-5-carboxamide, 200 ml of acetonitrile and 3.35 g (0.0242 mol) of sodium carbonate are introduced into a 500 ml round-bottomed flask equipped with a reflux condenser and placed under nitrogen. The mixture is heated at reflux for 22 h, is allowed to cool and the solvent is evaporated under reduced pressure. The residue is purified by chromatography on a column of silica gel, the eluent being a 100/0 to 85/15 dichloromethane/methanol mixture, and the solid obtained is recrystallized from ethyl acetate. 0.96 g (0.0027 mol) of base is obtained. The fumarate is prepared from 0.96 g of base in solution in 50 ml of methanol and from 0.31 g (0.0027 mol) of fumaric acid in solution in 50 ml of methanol. The mixture is concentrated under reduced pressure and the product crystallizes. 0.97 g of white solid is obtained. Melting point: 220-222 C.

Statistics shows that 5-Chloropyrazine-2-carboxamide is playing an increasingly important role. we look forward to future research findings about 21279-64-1.

Reference:
Patent; Synthelabo; US5420130; (1995); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4ClN3O

5-Chloropyrazinamide (1, 50 mg, 0.3173 mmol), potassiumfluoride (KF) (110.43 mg, 1.90 mmol) and tetra-n-butylammonium bromide (TBABr) (20.46mg, 0.064 mmol) were added to a 10 mL RBF and placed under vacuum for 1 hour to dry.After filling the RBF with N2, 10 mL of dry DMSO stored over molecular sieves was added tothe RBF. The reaction mixture was heated to 110 C and refluxed for 30 min under N2. Afterthe reaction was shown to be complete by TLC, the mixture was cooled to room temperature, diluted with iced water and then extracted with ethyl acetate. The organic layer was dried withMgSO4 and the solvent was evaporated by vacuum to yield crude product which was purifiedby CombiFlash chromatography using a silica column and petroleum ether and ethyl acetateas the eluent.GC-EI Mass. Calculated for C5H4FN3O (M·+) 141.11, found 141.11. Two fragments peakswere also observed: M-CONH2·+ (C4H2FN2·+), m/z = 97.07 and M-CONH+ (C4H2FN2H+),m/z = 98.08.1H NMR (400 MHz, CDCl3 and CD3OD): delta 9.00 (s, 1H), delta 8.36 (d, J = 7.8 Hz, 1H). 19FNMR (400 MHz, CDCl3 and CD3OD): delta 75.17 (d, J = 7.3 Hz). 13C NMR (500 MHz, CDCl3and CD3OD): delta 164.72 (s, 1′-C), delta 161.56 (d, J = 256.5 Hz, 5′-C), delta 142.41 (d, J = 12.8 Hz, 3′-C),delta 142.27 (d, 2′-C) delta 131.78 (d, J = 38.7 Hz, 6′-C)

The synthetic route of 21279-64-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Zhuo; Ordonez, Alvaro A.; Smith-Jones, Peter; Wang, Hui; Gogarty, Kayla R.; Daryaee, Fereidoon; Bambarger, Lauren E.; Chang, Yong S.; Jain, Sanjay K.; Tonge, Peter J.; PLoS ONE; vol. 12; 2; (2017);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5-Chloropyrazine-2-carboxamide

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

According to the analysis of related databases, 21279-64-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Servusova, Barbora; Paterova, Pavla; Mandikova, Jana; Kubicek, Vladimir; Kucera, Radim; Kunes, Jiri; Dolezal, Martin; Zitko, Jan; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 450 – 453;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 21279-64-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 21279-64-1 name is 5-Chloropyrazine-2-carboxamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-[18F]F-PZA was synthesized via a halogen exchange reaction, similar to the method used tosynthesize 5-F-PZA (Fig 2). 2960 MBq (80 mCi) of aqueous [18F]fluoride in ddH2O was purchasedfrom PETNET Solutions Inc. The [18F]fluoride was placed in a vial containing Kryptofix2.2.2 (5 mg, 13 mumol) and potassium carbonate (1 mg, 7 mumol) and the solution was thendried by azeotropic distillation. The solid residue was then re-solubilized with 0.2±0.3 mL ofacetonitrile containing 1±2 mg 5-chloropyrazinamide (5-Cl-PZA). The reaction mixture washeated in a securely capped 2 mL reaction vial at 105C for 8 min, and subsequently quenchedwith 0.8 mL water. The reaction mixture was filtered through a vented 0.22 um Millipore filterusing a 1 mL syringe and then purified by HPLC with an isocratic mobile phase of 8% acetonitrile/92% 0.02Maqueous ammonium acetate with 5% acetic acid (Phenomenex Luna PFP,250 × 10, 5 mum, 4 mL/min). The radioactive product eluted at the same retention time as the5-F-PZA standard (10 to 12 min). The solvent was removed by rotary evaporation. The residuewas re-solubilized in sterile phosphate buffered saline and the pH of the solution was adjustedto 7.4 by the addition of 2M NaOH. The solution was filtered through an Acrodisc 13 mmsyringe filter equipped with a 0.2 mum Supor membrane (Pall Corporation) into a sterile vial.Radiochemical purity was determined by reverse-phase analytical HPLC (Phenomenex PFP,250 × 4.6, 5 mum, 1 mL/min, 8% acetonitrile/92% 0.02Maqueous ammonium acetate with 5%acetic acid mobile phase).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloropyrazine-2-carboxamide, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Zhuo; Ordonez, Alvaro A.; Smith-Jones, Peter; Wang, Hui; Gogarty, Kayla R.; Daryaee, Fereidoon; Bambarger, Lauren E.; Chang, Yong S.; Jain, Sanjay K.; Tonge, Peter J.; PLoS ONE; vol. 12; 2; (2017);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 21279-64-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Servusova, Barbora; Paterova, Pavla; Mandikova, Jana; Kubicek, Vladimir; Kucera, Radim; Kunes, Jiri; Dolezal, Martin; Zitko, Jan; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 450 – 453;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 21279-64-1

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

The synthetic route of 5-Chloropyrazine-2-carboxamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Servusova, Barbora; Paterova, Pavla; Mandikova, Jana; Kubicek, Vladimir; Kucera, Radim; Kunes, Jiri; Dolezal, Martin; Zitko, Jan; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 450 – 453;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 21279-64-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

The chemical industry reduces the impact on the environment during synthesis 5-Chloropyrazine-2-carboxamide. I believe this compound will play a more active role in future production and life.

Some common heterocyclic compound, 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, molecular formula is C5H4ClN3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H4ClN3O

Example 14 (compound No. 234)2,2,2-Trifluoro-1 -(trifluoromethyl)ethyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine- 1 -carboxylate14.1 . ie f-Butyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine-1 -carboxylate; A mixture of 1.12 g (7.15 mmol) of 5-chloropyrazine-2-carboxamide, 1.95 g (8.58 mmol) of ie f-butyl 4-(2-aminoethyl)piperidine-1 -carboxylate and 1 .18 g (8.58 mmol) of potassium carbonate in 1 .4 ml of dimethyl sulphoxide is heated during 5 hours at 100C under an argon atmosphere and with stirring. After cooling to ambient temperature, 25 ml of ethyl acetate and 25 ml of water are added. The organic phase is separated by settling and washed 3 times with 25 ml of water and then 25 ml of a saturated aqueous sodium chloride solution. It is dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on silica gel, elution being carried out with a 97:3, then 95:5 and 93:7 mixture of dichloromethane and methanol, in order to obtain 1 .99 g (5.69 mmol) of product in the form of a light-yellow paste.1H NMR (CDCI3, delta ppm, 200 MHz): 8.65 (s, 1 H), 8.10 (s, 1 H), 7.55 (m, 1 H), 5.75 (m, 1 H), 4.85 (m, 1 H), 4.15 (m, 2H), 3.45 (m, 2H), 2.75 (t, 2H), 1 .80-1 .60 (m, 5H), 1 .50 (s, 9H), 1 .35-1 .10 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21279-64-1, its application will become more common.

Electric Literature of 21279-64-1, These common heterocyclic compound, 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

Statistics shows that 5-Chloropyrazine-2-carboxamide is playing an increasingly important role. we look forward to future research findings about 21279-64-1.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloropyrazine-2-carboxamide

15 g (95.2 mmol) of 5-chloropyrazine-2-carboxamide,24.8 g (114.2 mmol) of 3-methoxy-4-hydroxybenzyl bromide,475.8 ml of DMF,33 g (238.7 mmol) of potassium carbonate were added sequentially to a 1-liter four-necked reaction flask,The reaction was carried out at 80 C for 6 hours,After the reaction is completed, the heating is stopped,Stirring was continued overnight (TLC detection, developing solvent: ethyl acetate: n-hexane = 1: 1)And then filtered to remove insoluble matter,The filtrate was transferred to a 2-liter reaction flask,To the filtrate was added 960 ml of water,Stirring under ice bath for about 3 hours crystallization, filtration, filter cake washed with 50 ml of X2 water,The filter cake was dried at 45 C,To give 24.8 g of a pale yellow solid (yield: 75.5%, purity: 97.6%).

The synthetic route of 21279-64-1 has been constantly updated, and we look forward to future research findings.