Category: 20737-42-2

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C5H4N2O3, 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a document, author is Kirkman-Davis, Emma, introduce the new discover.

Pyrazine-bridged Cu(II) chains: diaquabis(n-methyl-2-pyridone)copper(II) perchlorate complexes

A family of pyrazine-bridged, linear chain complexes of Cu(II) of the formula [CuL2(H2O)(2)(pz)](ClO4)(2) [pz = pyrazine; L = n-methyl-2(1H)-pyridone, n = 3 (1), 5 (2), and 6 (3)] has been prepared. Single-crystal X-ray diffraction shows six-coordinate, pyrazine-bridged chains with trans-pairs of ancillary ligands. The substituted pyridine molecules exist in their pyridone tautomers and are coordinated through the carbonyl oxygen atom. The structure is stabilized by intramolecular hydrogen bonds between the pyridone and water molecule, and via hydrogen bonds between the water molecules and perchlorate ions. 2 undergoes a crystallographic phase transition between C2/c (high temperature phase) and P (1) over bar (low temperature phase). Powder EPR spectra reveal that all complexes are rhombic, although differences between g(x) and g(y) can only be seen clearly at Q-band. Variable temperature magnetic susceptibility data show antiferromagnetic interactions and the data were fit to the uniform chain model yielding J/k(B) = -9.8, -9.2 and -11 K for 1-3 respectively. Attempts to model an interchain interaction strength indicate that the chains are very well isolated.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20737-42-2 is helpful to your research. Computed Properties of C5H4N2O3.

Application of 20737-42-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a article, author is Seo, Yohan, introduce new discover of the category.

Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells

In connection with our continued research to generate new aza-fused heteroaromatic chemical scaffolds, we developed a highly atom-economical three-component route to novel 3,4-dihydropyrrolo[1,2-a] pyrazine ring skeleton multi-functionalized on the pyrazine unit. This [4+1+1] annulation approach led us to gain access to a new N-fused bicyclic chemical space having two distinctive functional groups (heteroaryl and aroyl) in a trans manner. Investigation of anticancer activity of the synthesized compounds and their derivatives revealed that (3R*,4S*)-3-(4-bromophenyl)-4-(4-fluorobenzoyl)-2-(2-oxo-2-phenylethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2-ium bromide (3h) has potent anticancer activity. 3h significantly inhibited cell viability in prostate cancer cells (PC-3) and breast cancer cells (MCF-7) with IC50 value of 1.18 +/- 0.05 mu M and 1.95 +/- 0.04 mu M, respectively. In addition, 3h strongly reduced cell migration in a dose dependent manner, and induced apoptosis via caspase-3 activation and cleavage of PARP in PC-3 and MCF-7 cells. Our results in this study imply that 3h can be a potential anticancer agent against prostate cancer and breast cancer. (C) 2019 Elsevier Masson SAS. All rights reserved.

Application of 20737-42-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 20737-42-2.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20737-42-2, name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., SDS of cas: 20737-42-2

Example 4 (6-Chloro-lH-indol- -yl)[2-[(4-fluorobenzyl)amino]pyrazin-3-yl]methanone 3-Chloro-2-pyrazinecarbonyl chloride. 3-Hydroxy-2-pyrazinecarboxylic acid (455 mg, 3.27 mmol) in POCI3 (6 mL) was treated with 3 drops of pyridine and heated to reflux for 2h. Once at rt, the reaction was cone, to dryness. The residue was dissolved in toluene and cone, in vacuo and then triturated with hexanes (4 x 10 mL). The hexanes washes decanted, combined and cone. This material in toluene (10 mL) containing 1 drop of DMF was treated with neat SOCl2 (2 mL) and heated at reflux for 3 h. The mixture was decanted and cone, in vacuo. The residue was dissolved in toluene and cone, to give 355 mg of a purple liquid that solidified on standing.

The synthetic route of 20737-42-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HOGENKAMP, Derk; WO2013/169907; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20737-42-2, name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Product Details of 20737-42-2

EXAMPLE 67 3-Hydroxypyrazine-2-carboxylic acid is converted to the methyl ester and the ester is reduced with lithium aluminium hydride in tetrahydrofuran to give 3-hydroxy-2-hydroxymethylpyrazine.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Smith Kline & French Laboratories Limited; US3950333; (1976); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

20737-42-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20737-42-2, name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

Example 6. Production of N-{3-isobutyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]pheny}-3-chloropyrazine-2-carboxamide (compound No. 1-25) 3-Hydroxypyrazine-2-carboxylic acid (154 mg, 1.1 mmol) was dissolved in phosphorus oxychloride (2 ml), followed by adding one drop of pyridine, refluxing under heating for 2 hours. After that, the reaction solution was concentrated under reduced pressure to obtain 3-chloropyrazine-2-carboxylic acid chloride. The compound was added to a tetrahydrofuran solution (10 ml) of 3-isobutyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]aniline (299 mg, 1 mmol) and triethylamine (303 mg, 3 mmol) and refluxed under heating for 3 hours. The reaction solution was diluted with ethyl acetate, followed by washing with water. The organic layer was dried over magnesium sulfate anhydride, and concentrated under reduced pressure, and then the residue was purified by using silica gel chromatography (hexane:ethyl acetate=2:1) to obtain 200 mg of the desired compound. Yield: 46% Property: Melting point 128 to 129C

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; NIHON NOHYAKU CO., LTD.; EP1757595; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20737-42-2, name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., 20737-42-2

Preparation of (S)-3-(4-cyanophenyl)-2-((4-(((5-fluoro-1H-benzo[d]imidazol- 2-yl)methyl)amino)-6-((3-((4-(3-hydroxypyrazine-2-carbonyl)piperazin-1- yl)methyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)-N,N-dimethylpropanamide (TA1021). HATU (1.2 equiv., 34 mg, 0.093 mmol) was added to a solution of 3-hydroxypyrazine-2- carboxylic acid (I-6, 1.1equiv., 12 mg, 0.080 mmol, Synthonix, Fisher Scientific) in anhydrous DCM (0.70 mL) and DIPEA (3equiv., 0.040 mL, 0.23 mmol). After being stirred at r.t. for 10 minutes, TA1013 (50 mg, 0.080 mmol) was added. The reaction was stirred at r.t. until the LCMS analysis showed complete consumption of the starting material (3-24h). The crude residue was then purified by reverse phase preparative HPLC (XBridge BEH, 19×150 mm, 5mum, C18 column; ACN/water with 0.1% formic acid modifier, 20mL/min), affording Compound TA1021 (17.3 mg, 29%) as an orange solid. 1H NMR (400 MHz, DMSO-d6) d 12.20 (s, 1H), 8.95 (d, J = 24.1 Hz, 1H), 8.07- 7.87 (m, 1H), 7.84- 7.68 (m, 1H), 7.68- 7.41 (m, 4H), 7.40- 7.22 (m, 2H), 7.22- 6.78 (m, 3H), 6.56 (s, 1H), 5.18- 4.91 (m, 1H), 4.79- 4.50 (m, 2H), 3.74- 3.39 (m, 7H), 3.28- 3.13 (m, 4H), 3.12- 2.78 (m, 5H), 2.75- 2.66 (m, 1H), 2.61 (s, 1H), 2.48- 2.02 (m, 4H). MS (m/z): 771 [M+1]+, LCMS purity: 99%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ADURO BIOTECH, INC.; KATIBAH, George Edwin; KIM, Jung Yun; NDUBAKU, Chudi Obioma; ROBERTS, Tucker Curran; TJANDRA, Meiliana; (165 pag.)WO2019/245910; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem