Category: 20737-42-2

These common heterocyclic compound, 20737-42-2, name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid

Preparation of methyl (S)-3-(4-cyanophenyl)-2-((4-((3-((4-(3-hydroxypyrazine-2- carbonyl)piperazin-1-yl)methyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)propanoate (TA1026). HATU (1.2 equiv., 45 mg, 0.12 mmol) was added to a solution of 3- hydroxypyrazine-2-carboxylic acid (I-6, 1.1equiv., 15 mg, 0.11 mmol) in anhydrous DCM (1.5 mL) and DIPEA (3equiv., 0.040 mL, 0.23 mmol). After being stirred at r.t.10 minutes, TA1047 (1equiv., 46 mg, 0.098 mmol) was added. The resulting suspension was stirred at r.t. 1 h, followed by DMF (0.1 mL). Then the reaction was stirred for another 2 h until the LCMS analysis showed complete consumption of the starting material. The crude residue was then purified by reverse phase preparative HPLC (XBridge BEH, 19×150 mm, 5mum, C18 column; ACN/water with 0.1% formic acid modifier, 20mL/min), affording Compound TA1026 (15.1 mg, 25%) as a yellow solid.1H NMR (400 MHz, Methanol-d4) d 8.12 (d, J = 10.2 Hz, 1H), 7.71 – 7.65 (m, 2H), 7.61 (d, J = 8.0 Hz, 2H), 7.49 (s, 2H), 7.43 (d, J = 7.9 Hz, 3H), 7.34- 7.27 (m, 1H), 7.08 (dd, J = 17.7, 7.0 Hz, 1H), 4.96 (dd, J = 8.6, 5.8 Hz, 1H), 3.83- 3.77 (m, 2H), 3.71 (s, 2H), 3.60 (s, 2H), 3.43- 3.39 (m, 3H), 3.25- 3.14 (m, 3H), 2.58 (dt, J = 36.9, 4.7 Hz, 5H). MS (m/z): 595 [M+1]+, LCMS purity: 99%.

The synthetic route of 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ADURO BIOTECH, INC.; KATIBAH, George Edwin; KIM, Jung Yun; NDUBAKU, Chudi Obioma; ROBERTS, Tucker Curran; TJANDRA, Meiliana; (165 pag.)WO2019/245910; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 20737-42-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20737-42-2 as follows.

STEP 2. 3-CHLORO-PYRAZTNE-2-CARBONYL CHLORIDE; [00202 ] 3 -Hydroxy -pyrazine-2-carboxylic acid (154 mg, 1.1 mmol) was dissolved in phosphorus oxy chloride (2 ml) followed by adding one drop of pyridine. The mixture was heated to reflux for 2h. After that, the reaction solution was concentrated under reduced pressure to give 3-chloropyrazine-2-carboxylic acid chlori

According to the analysis of related databases, 20737-42-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; ANDREWS, Kristin L.; FROHN, Michael J.; HARRINGTON, Paul E.; PICKRELL, Alexander J.; RZASA, Robert M.; WO2011/143129; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In an article, author is Hisaki, Ichiro, once mentioned the application of 20737-42-2, Quality Control of 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, molecular formula is C5H4N2O3, molecular weight is 140.0969, MDL number is MFCD00235136, category is Pyrazines. Now introduce a scientific discovery about this category.

Positional Effects of Annelated Pyrazine Rings on Structure and Stability of Hydrogen-Bonded Frameworks of Hexaazatrinaphthylene Derivatives

A porous hydrogen-bonded organic framework (HOF) composed of N-hetero pi-conjugated molecules (N pi-HOF) is a promising candidate for multifunctional porous materials. However, such HOFs are still limited and only a handful of examples have been reported. In this study, we investigated the positional effects of annelated pyrazine rings on the structure and stability of N pi-HOFs to establish a design principle for N pi-HOFs. A new isomer of hexaazatrinaphthylene (CPBTQ) was synthesized and subjected to N pi-HOF construction, activation, and an evaluation of stability and permanent porosity. A comparison between two kinds of N pi-HOFs composed of isomers (CPBTQ and CPHATN) possessing three pyrazine rings annelated at different positions indicates that the positional difference of the pyrazine rings strongly affects the conformation of the peripheral phenylene groups, which then leads to different structures and stabilities of the N pi-HOFs. The activated N pi-HOF composed of CPBTQ (CPBTQ-1a) is revealed to exhibit a Brunauer-Emmett-Teller surface area of 471 m(2) g(-1) and shows HCl responsiveness thanks to the basic pyrazine rings annelated to the triphenylene core. We believe that the present results can contribute not only to the construction of multifunctional porous materials but also to the chemistry of heteroaromatic compounds.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, molecular formula is C5H4N2O3. In an article, author is Burgut, Aykut,once mentioned of 20737-42-2, Product Details of 20737-42-2.

Growth inhibition of foodborne pathogens by co-microencapsulation of lactobacilli cell free and propolis extracts

Cell free extracts (CFE) obtained fromLactobacillus plantarumFI 8595 andLactobacillus reuteriATCC 55730 alone or in combination with propolis ethanolic or water extracts (1%) were microencapsulated with maltodextrin (25%) before the subsequent spray drying process. They were morphologically characterized by scanning electron microscope. Chemical compositions of pure extracts were identified by gas chromatography-mass spectrometry. Antimicrobial activities of pure and microencapsulated extracts against four foodborne pathogens (Staphylococcus aureusATCC29213,Listeria monocytogenesATCC19112,Klebsiella pneumoniaeATCC700603 andSalmonellaParatyphi A NCTC13) were determined using agar well diffusion, broth microdilution and time kill assays. CFE fromL. reuteriandL. plantarumconsisted of acetic acid, pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(phenylmethyl)-, 2,3,4-trihydroxybenzaldehyde and 9-octadecenoic acid. The results also indicated the presence of two respective major compounds, namely, 2-methoxy-4-vinylphenol (19.03%) and trans-cinnamic acid (27.67%) in water and ethanolic propolis extracts. Presence of propolis extracts mainly ethanolic extract in microencapsulation led to higher inhibition zones against all foodborne pathogens (p < .05). The co-microencapsulation of CFE fromL. reuteriin combination with ethanolic or water extract of propolis resulted in 2.34- and 2.2-fold higher inhibition zone towardsL. monocytogenes.Pure and microencapsulated CFE fromL. reuteriresulted in 2.89 and 2.14 log cfu/ml reduction in growth ofS.Paratyphi A at 3 hr, respectively. The co-microencapsulation of CFE from lactobacilli and propolis extracts mainly ethanolic extract could be suggested as a novel antimicrobial on inhibition of food pathogens, as they contain abundant bioactive substances. If you¡¯re interested in learning more about 20737-42-2. The above is the message from the blog manager. Product Details of 20737-42-2.

In an article, author is Chen, Qi, once mentioned the application of 20737-42-2, HPLC of Formula: C5H4N2O3, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, molecular formula is C5H4N2O3, molecular weight is 140.0969, MDL number is MFCD00235136, category is Pyrazines. Now introduce a scientific discovery about this category.

The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism

Background: Heart failure (HF) is one of the most common causes of cardiovascular diseases in the world. Currently, the drugs used to treat HF in the clinic may cause serious side effects. Liguzinediol, 2, 5-dimethyl-3, 6-dimethyl-pyrazine, is a compound synthesized after the structural modification of ligustrazine (one active ingredient ofSzechwan Lovage Rhizome). We aimed to observe the effects of liguzinediol on preventing HF and explore the related mechanisms. Methods: The ligation of left anterior descending coronary artery was operated to established the myocardial infarction (MI) model in Sprague-Dawley rats. Cardiac functions were recorded by echocardiography and hemodynamics. The changes in the Renin-Angiotensin-Aldosterone System (RAAS), inflammation, and oxidative stress were detected by radioimmunoassay and Elisa kits. Western blot and real-time PCR were applied to determine the expressions of the TGF-beta 1/Smads pathway. Results: Firstly, liguzinediol enhanced the systolic and diastolic functions of the heart in MI rats. Liguzinediol improved ventricular remodeling by reducing myocardial cell necrosis, as well as reducing collagen deposition and myocardial fibrosis. Then, liguzinediol suppressed the activation of RAAS, inhibited the synthesis of pro-inflammation factors, and reduced oxidative stress. In the end, liguzinediol also down-regulated the expressions of the TGF-beta 1/Smads pathway. Conclusions: Liguzinediol could alleviate HF caused by MI in rats, and the protective effect was associated with the regulation of the TGF-beta 1/Smads pathway.

If you are interested in 20737-42-2, you can contact me at any time and look forward to more communication. HPLC of Formula: C5H4N2O3.

Electric Literature of 20737-42-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a article, author is Hu, Ming-Hao, introduce new discover of the category.

Pyrazine-based G-quadruplex fluorescent probes: Transformation between aggregation-induced emission and disaggregation-induced emission via slight variations in structures

G-quadruplexes (G4s) play key regulatory roles in biological processes, holding great potential as novel therapeutic targets. Fluorescent probes may help elucidate the structure-function relationships of G4s in biological systems, providing useful information for drug development. However, G4 probes through rational design are still limited, and the rationales of G4 probes are not well explored, which hinders the development of new G4 probes. In this work, we carried out a proof-of-concept study. Two pyrazine-based G4 fluorescent probes (PZ-1 and PZ-2) based on the AIE or DIE principles were first designed. Then, their fluorescence-triggering mechanisms upon binding to G4s were thoroughly investigated, demonstrating that slight variations in structures would result in transformation between AIE and DIE regarding these two probes. Next, the DIE probe PZ-2 was selected for further studies, which was demonstrated to be able to selectively sense kinds of G4s. Furthermore, the binding modes between PZ-2 and G4s were explored, revealing that G4s could dissociate PZ-2 aggregate and then accommodate its monomer through an end-stacking mode, thus triggering its fluorescence. Accordingly, this work provides new insights for the rational design of G4 fluorescent probes.

Electric Literature of 20737-42-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 20737-42-2 is helpful to your research.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a document, author is Yang, Sha, introduce the new discover, Formula: C5H4N2O3.

Surface Strain-Induced Collective Switching of Ensembles of Molecules on Metal Surfaces

A central difficulty in the design of molecular electronics is poor control of the contact state between the molecule and metal electrode, which may induce instability and noise in logic and memory devices and even destroy the intrinsic functionality of the device. Here, we theoretically propose a simple and effective strategy for realizing full control of the contact state of organic molecules coated on the metal surface by applying homogeneous surface strain. As exemplified by pyrazine molecules on Cu(111), application of compressive (tensile) strain causes the molecules to uniformly adopt the physisorbed (chemisorbed) state. Within the framework of non-equilibrium Green’s function calculations, we show that the two distinct contact states yield simultaneous rectification and switching behaviors. Because the contact states of all surface-bound molecules are transformed uniformly via surface strain perturbations, fully controlled collective switching and rectification effects can be simultaneously achieved in this contact system.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20737-42-2 is helpful to your research. Formula: C5H4N2O3.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid. In a document, author is Evenson, Sean J., introducing its new discovery. Safety of 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid.

Minimizing Polymer Band Gap via Donor-Acceptor Frameworks: Poly(dithieno[3,2-b:2 ‘,3 ‘-d]pyrrole-alt-thieno[3,4-b]pyrazine)s as Illustrative Examples of Challenges and Misconceptions

Donor-acceptor (D-A) frameworks have been produced via the copolymerization of the strong donor dithieno[3,2-b:2 ‘,3 ‘-d]pyrrole (DTP) with ambipolar thieno[3,4-b]pyrazine (TP) units to generate soluble, processible materials with band gaps as low as 0.8 eV. Optical and electronic characterization of the DTP-TP copolymers illustrate common misconceptions in the relative contributions of the comonomers to the D-A framework, as well as highlighting the challenges of minimizing band gap while also retaining desirable frontier orbital energies for application to technological devices.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 20737-42-2 help many people in the next few years. Safety of 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a document, author is Sumczynski, Przemyslaw, introduce the new discover, Recommanded Product: 20737-42-2.

On the acid-base properties of pyrazine-2-thiocarboxamide and its complexes with Fe(II), Cu(II), Zn(II) and Ni(II) in polar solvents

Add-base properties of 1,4-diazine-2-thiocarboxamide (PICA) most stable conformers were studied as well as its complexes with Fe(II), Cu(II), Zn(II) and Ni(II) in water, acetonitrile, methanol and ethanol solvents. All studies were performed by means of theoretical density functional method (DFf), and the solvents were modeled as a polarizable continuum. Due to significant differences in stability Iwo groups of conformers can be distinguished. Only one group, containing amino group, shall be observed experimentally. Full four-stage protonation and two-stage deprotonation maps of PICA have been revealed. The 1:1 and 2:1 series of complexes have been found with Fe(II), Cu(II), Zn( II) and Ni(II) cations. General complexation enthalpy characteristic was found as: Delta H-29(8_Cu2+) Delta H-298(_Ni2+) >> Delta H-298(_)Cu2(+) >> Delta H-298(_Zn2+), and Delta H-298(_ethanol) > Delta H-298(_)acetonitrile > Delta H-298(_)mehtanol > Delta H-298(_water). (C) 2020 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20737-42-2 is helpful to your research. Recommanded Product: 20737-42-2.

In an article, author is Leung, Ming-Yi, once mentioned the application of 20737-42-2, Product Details of 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, molecular formula is C5H4N2O3, molecular weight is 140.0969, MDL number is MFCD00235136, category is Pyrazines. Now introduce a scientific discovery about this category.

Thermally Stimulated Delayed Phosphorescence (TSDP)-Based Gold(III) Complexes of Tridentate Pyrazine-Containing Pincer Ligand with Wide Emission Color Tunability and Their Application in Organic Light-Emitting Devices

A new class of pyrazine-based carbazole-containing gold(III) complexes featuring thermally stimulated delayed phosphorescence (TSDP) properties has been designed and synthesized. The emission colors are found to be sensitive to the coordinating atom of the carbazolyl ligands at the gold(III) center, with emission energies spanning from green to red. The efficiency of TSDP can be enhanced by lowering the polarity of the solvent, as supported by the variable-temperature emission and computational studies. Interestingly, a significant spectral shift in electroluminescence with the change of Commission Internationale de L’Eclairage (CIE) coordinates from (0.35, 0.60) to (0.44, 0.54) has been achieved by simply changing the host material from CBP to TmPyPB. Solution-processable organic light-emitting devices (OLEDs) have also been fabricated, with maximum current efficiencies of up to 22.4 cd A(-1) and maximum external quantum efficiencies (EQEs) approaching 7.0%. A higher current efficiency of 35.1 cd A(-1) and EQE of 10.7% can be achieved for the vacuum-deposited device based on 1, representing the first demonstration of pyrazine-based tridentate ligand-containing gold(III) complexes as phosphorescent material for OLED application.

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