Category: 19847-12-2

In an article, author is Zhang, Yu, once mentioned the application of 19847-12-2, Name is Pyrazinecarbonitrile, molecular formula is C5H3N3, molecular weight is 105.1, MDL number is MFCD00049361, category is Pyrazines. Now introduce a scientific discovery about this category, Application In Synthesis of Pyrazinecarbonitrile.

Multi-Index Quantitative Evaluation of Angelicae sinesis Radix Based on H-1-qNMR

Background: As known to us, HPLC method was often used to determine the contents of Angelicae sinesis Radix. In view of the shortcomings of HPLC method, qNMR has prominent advantages in determining the contents of bioactive components in the quantitative and qualitative analysis of Angelicae sinesis Radix. Objective: In this study, a quick, simple, and accurate method was established to determine the components of ferulic acid, coniferyl ferulate, and ligustilide in Angelicae sinesis Radix. Method: Using dimethyl sulfoxide-d(6)(DMSO-d(6)) as the test solvent and pyrazine as the internal standard substance, H-1-qNMR measurement was performed on a 600 MHz spectrometer. The quantitative resonance peaks of pyrazine, ferulic acid, ligustilide, and coniferyl ferulate were at delta 8.66 ppm, delta 6.35-6.37 ppm, delta 5.53-5.55 ppm, and delta 6.50-6.53 ppm, respectively. Results: The linear relationship, limit of detection, limit of quantification, precision, stability, and recovery were verified and the results were good. On the other hand, it was verified by HPLC, and the HPLC used for verification passed the methodological investigation of linearity, precision, repeatability, stability, and recovery, and the results were good. In addition, no significant difference in results was found between the( )1H-qNMR and HPLC-UV methods in determining the content of three components in three batches of Angelicae sinesis Radix. Conclusions: The method can be used for simultaneous determination of three active components, and providing a scientific basis for the overall quality evaluation and quality control of Angelicae sinesis Radix. Hightlights: In this study, H-1-qNMR was used to determine ferulic acid, coniferyl ferulate and ligustilide in Angelicae Sinensis Radix for the first time.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 19847-12-2, Application In Synthesis of Pyrazinecarbonitrile.

Application of 19847-12-2, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Kim, Sung June, introduce new discover of the category.

Regioselective Functionalization of N-Fused Heteroaromatics via FeCl3-Catalyzed Nucleophilic Addition to Activated N-Heterocycles

Broadening of nitrogen-fused heteroaromatic chemical space such as indolizine and pyrrolo[1,2-a]pyrazine was achieved via FeCl3-catalyzed nucleophilic addition of these N-fused aromatic compounds to a wide range of azolinium systems generated in situ, leading to novel N-fused heteroaromatic scaffolds with dearomatized N-heterocyclic substituents regioselectively. Nucleophilic addition of indolizines and pyrrolo[1,2-a]pyrazines mainly occurred at the C1 position of the isoquinoliniums and at the C4 site of the quinoliniums.

Application of 19847-12-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 19847-12-2 is helpful to your research.

In an article, author is Chylewska, Agnieszka, once mentioned the application of 19847-12-2, Recommanded Product: Pyrazinecarbonitrile, Name is Pyrazinecarbonitrile, molecular formula is C5H3N3, molecular weight is 105.1, MDL number is MFCD00049361, category is Pyrazines. Now introduce a scientific discovery about this category.

Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent

Carbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,H-1 and(13)C NMR), electrochemical (cyclic voltammetry), and optical techniques, to receive the complete structural analysis, physicochemical (pKa, logP) and biological profile of a new carbazole derivative with acronym 3,6-PIRAMICAR. The interaction ability of the compound studied with potential cellular targets like Calf Thymus DNA (CT-DNA), or Bovine Serum Albumin (BSA) were also taken into account. Experiments showed the existence of strong binding, but no DNA or BSA cleavage was observed. The comparative analyzes of compounds anti-Candida action clearly show pH-dependent antifungal activity of 3,6-PIRAMICAR, which was strongly stimulated in the acidic media. Surprisingly, the titled compound turn out to be much more effective (14 times by MIC50; 8 times by MIC; c.a. 4 times by MFC) against Candida krusei than fluconazole at pH 4.

If you are interested in 19847-12-2, you can contact me at any time and look forward to more communication. Recommanded Product: Pyrazinecarbonitrile.

Chemistry is an experimental science, Recommanded Product: Pyrazinecarbonitrile, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 19847-12-2, Name is Pyrazinecarbonitrile, molecular formula is C5H3N3, belongs to Pyrazines compound. In a document, author is Isawi, Israa H..

GPR6 Structural Insights: Homology Model Construction and Docking Studies

GPR6 is an orphan G protein-coupled receptor that has been associated with the cannabinoid family because of its recognition of a sub-set of cannabinoid ligands. The high abundance of GPR6 in the central nervous system, along with high constitutive activity and a link to several neurodegenerative diseases make GPR6 a promising biological target. In fact, diverse research groups have demonstrated that GPR6 represents a possible target for the treatment of neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. Several patents have claimed the use of a wide range of pyrazine derivatives as GPR6 inverse agonists for the treatment of Parkinson’s disease symptoms and other dyskinesia syndromes. However, the full pharmacological importance of GPR6 has not yet been fully explored due to the lack of high potency, readily available ligands targeting GPR6. The long-term goal of the present study is to develop such ligands. In this paper, we describe our initial steps towards this goal. A human GPR6 homology model was constructed using a suite of computational techniques. This model permitted the identification of unique GPR6 structural features and the exploration of the GPR6 binding crevice. A subset of patented pyrazine analogs were docked in the resultant GPR6 inactive state model to validate the model, rationalize the structure-activity relationships from the reported patents and identify the key residues in the binding crevice for ligand recognition. We will take this structural knowledge into the next phase of GPR6 project, in which scaffold hopping will be used to design new GPR6 ligands.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 19847-12-2, in my other articles. Recommanded Product: Pyrazinecarbonitrile.

Electric Literature of 19847-12-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Gawad, Jineetkumar, introduce new discover of the category.

Design, synthesis and biological evaluation of novel 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives as a potential DprE1 inhibitors

In a search of new potentially active antitubercular agents, here we have initiated with pharmacophore development, virtual screening and molecular docking studies to know flexible binding modes with target cavity of DprE1 enzyme. We have designed and synthesized 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives and evaluated for antitubercular activity with specific DprE1 inhibition. The various steps have been completed by performing conden-sation of 6-(trifluoromethyl)quinazoline-2-carboxylic acid, aromatic aldehydes, methanol, Hydrazine hydrate,-(trifluoromethyl)quinazoline-2-carbohydrazide, 6-(trifluoromethyl)-N’-methylenequinazoline-2-carbohydrazide to obtained 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives (3a-r) in better yields. Synthesized derivatives were characterized for their spectral anal-ysis. These compounds have been screened for their in vitro antitubercular activity against Mycobacte-rium tuberculosis H 37 RV. The compounds 3a (MIC-1.27 m M); 3e (MIC-1.12 m M); 3p (MIC-1.18 m M); and 3r (MIC-0.96 m M); exhibited notable in vitro antitubercular activity compare to the reference standard, Isoniazid. These four compounds were screened for DprE1 enzyme assay. Among those 3e and 3r has shown strong DprE1 inhibition, these compounds were substituted with nitro and hydroxyl group. (c) 2020 Elsevier B.V. All rights reserved.

Electric Literature of 19847-12-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 19847-12-2.

Reference of 19847-12-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Zhou, Jiadi, introduce new discover of the category.

delta-Regioselective heteroarylation of free alcohols through 1,5-hydrogen-atom transfer

An efficient silver-catalyzed d-regioselective C(sp(3))-H heteroarylation of free alcohols has been developed. Various alcohols reacted with quinolines, isoquinoline, pyridines, pyrimidine, phthalazine, 4-hydroxyquinazoline, acridine, quinoxaline and pyrazine to give the corresponding C(sp(2))-H alkylation products in 31-89% yields. Notably, all types (1 degrees, 2 degrees, and 3 degrees) of d-C(sp(3))-H bonds in the alcohols could be regioselectively activated. This protocol provides a platform to access divergent functionalizations of alcohols and heteroaryls by forming the challenging d-selective C(sp(3))-C(sp(2)) bond.

Reference of 19847-12-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 19847-12-2.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, in an article , author is Tomer, Nisha, once mentioned of 19847-12-2, HPLC of Formula: C5H3N3.

A chromone based Schiff base: An efficient colorimetric sensor for specific detection of Cu (II) ion in real water samples

A new chromone based Schiff base ligand L was synthesized by the condensation of 3-formyl chromone and pyrazine-2-carbohydrazide as a colorimetric probe to detect Cu (II) ions selectively. An instant visual colour change from colourless to yellow was obtained on addition of Cu2+ ions to the probe L solution, while other metal ions found ineffective. The ligand L was characterized by H-1 NMR, FTIR and HRMS spectral techniques. UV-Visible spectroscopic technique was used to study the sensing ability of probe L for copper ions above other metal ions. The Job’s plot obtained from absorption studies and HRMS data confirmed that the Cu2+ ions bind with ligand L in 1:1 stoichiometric ratio. DFT computations were also supported the binding framework between L and Cu (II) ions. The LOD value and the association constant were obtained 3.9 x 10(-7) M and 2.3 x 10(5) M-1 respectively, via Benesi-Hildebrand equation. Selectivity of L towards Cu2+ ions was also studied and it was found that the probe L worked specifically for copper ions without any considerable influence of other intruding metal ions. In addition, in real water samples, the ligand L was fully implemented for identification and quantification of Cu2+ ions. (C) 2020 Elsevier B.V. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 19847-12-2, you can contact me at any time and look forward to more communication. HPLC of Formula: C5H3N3.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 19847-12-2, Name is Pyrazinecarbonitrile, molecular formula is C5H3N3. In an article, author is Shi, Fu,once mentioned of 19847-12-2, SDS of cas: 19847-12-2.

A high selective fluorescent sensor for Cu2+ in solution and test paper strips

A novel and efficient fluorescent sensor with a pyrazine triphenylamine unit was developed. The sensor exhibits large Stokes shift (216 nm) due to the excited-state intramolecular proton transfer (ESIPT) process. After complexing with Cu2+, the ESIPT process was blocked and the fluorescence of the sensor was quenched. Job’s plot and ESI-MS results indicated that the stoichiometric ratio between the sensor and Cu2+ was 1:1. The detection limit was determined to be 2.47 x 10(-8) mol L-1. The sensor could be used to detect Cu2+ in practical samples with high accuracy. Furthermore, the sensor also could be made into test paper strips for the qualitative and quantitative detection of Cu2+.

Interested yet? Keep reading other articles of 19847-12-2, you can contact me at any time and look forward to more communication. SDS of cas: 19847-12-2.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 19847-12-2, Name is Pyrazinecarbonitrile. In a document, author is Elkamhawy, Ahmed, introducing its new discovery. Quality Control of Pyrazinecarbonitrile.

Discovery ofN-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

Herein, two new series ofN-substituted indole-based analogues were rationally designed, synthesizedviamicrowave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hitsVIandVII, compounds4band4eexhibited higher inhibitory activities over MAO-B with IC(50)values of 1.65 and 0.78 mu M, respectively. When compared to the modest selectivity index of rasagiline (II, a well-known MAO-B inhibitor, SI > 50), both4band4ealso showed better selectivity indices (SI > 60 and 120, respectively). A further kinetic evaluation of the most potent derivative (4e) displayed a competitive mode of inhibition (inhibition constant (K-i)/MAO-B = 94.52 nM). Reasonable explanations of the elicited biological activities were presentedviaSAR study and molecular docking simulation. Accordingly, the remarkable MAO-B inhibitory activity of4e(N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide), with its selectivity and competitive inhibition, advocates its potential role as a promising lead worthy of further optimization.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 19847-12-2 help many people in the next few years. Quality Control of Pyrazinecarbonitrile.

Application of 19847-12-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19847-12-2, name is Pyrazinecarbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Preparation 53; C-Pyrazin-2-yl-methylamine; In a Parr bottle, charge pyrazine-2-carbonitrile (1 g) in absolute ethanol (10mol). Add 10% Pd-C (w/w, 0.4g) and place on a Parr Hydrogenation Apparatus under 50 psig hydrogen at ambient temperature for sixteen hours. Filter the mixture through a pad of Celite. Purify material on SCX column. Use crude basic material in next step without further purification.

The chemical industry reduces the impact on the environment during synthesis Pyrazinecarbonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/66126; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem