Category: 19838-08-5

Some common heterocyclic compound, 19838-08-5, name is 3-Methylpyrazin-2-amine, molecular formula is C5H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3-Methylpyrazin-2-amine

A.2: Chemical Synthesis for compounds N-alkylatbetad deriva- tives (R31 ? H)Starting material: (3-Chloro-phenyl) – ( 8-methyl-2-phenyl- imidazo [1, 2-a]pyrazin-3-yl) -amineTo a stirred solution of 3-methyl-2-pyrazineamine (10.9 g, 100 mmol; see Example 1.1), benzaldehyde (15.9 g, 150 mmol) and Yb(OTf)3 (3.1 g, 5 mol%, 5 mmol) in abs. MeOH (200 mL) 3-chlorophenylisonitrile (15.1 g, 110 mmol) as a solution in abs. MeOH (100 mL) was added under argon. The reaction mixture was allowed to stir overnight (18 h) and after TLC control for additional 5 hours more until the starting 3-methyl-2-pyrazineamine was comsumed. The reaction mixture was concentrated to 1/3 of its initial vol- ume and was cooled down to -100C for crystallization. After approx. 2 days in a freezer light-yellow precipitate deposited. It was collected by filtration, washed with several portions of pre-cooled abs. MeOH (-100C) and dried under high vacuum for 24 h. MS: m/z = 335.7 (M++l; MW = 334.81); HPLC: Rt = 2.00 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19838-08-5, its application will become more common.

Reference:
Patent; ONCALIS AG; CAPRARO, Hans-Georg; WO2010/83617; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

19838-08-5,Some common heterocyclic compound, 19838-08-5, name is 3-Methylpyrazin-2-amine, molecular formula is C5H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-Methyl-pyrazin-2-ylamine (2) (109 mg, 1.0 mmol), benzaldehyde (106 mg, 1.0 mmol) and 3-chloro- phenylisonitrile (138 mg, 1.0 mmol) were dissolved in a mixture of dry methanol (2.0 mL) and trimethyl orthoformate (2.0 mL) under argon. The mixture was stirred at 60C for 3 hours, then cooled to rt. An analytically pure sample of 3 was obtained from the crude product using preparative HPLC

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19838-08-5, its application will become more common.

Reference:
Patent; ESBATECH AG; WO2005/120513; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19838-08-5, name is 3-Methylpyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., 19838-08-5

3-Methyl-pyrazin-2-ylamine (2) (109 mg, 1.0 mmol) , benzaldehyde (106 mg, 1.0 mmol) and 3-chloro- phenylisonitrile (138 mg, 1.0 mmol) were dissolved in a mixture of dry methanol (2.0 mL) and trimethyl orthofor- mate (2.0 mL) under argon. The mixture was stirred at 6O0C for 3 hours, then cooled to rt . An analytically pure sample of 3 was obtained from the crude product using preparative HPLC.

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Reference:
Patent; ESBATECH AG; WO2006/131003; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

19838-08-5, Name is 3-Methylpyrazin-2-amine, 19838-08-5, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

(iii) A solution of bromine (0.26 ml) in chloroform (40 ml) was added dropwise to a stirred solution of 2-amino-3-methylpyrazine (0.453 g) and pyridine (0.4 ml) in chloroform (100 ml) with shielding from sunlight, over a period of 1 hour. The reaction mixture was stirred for a further 30 minutes and then water (25 ml) was added. The organic layer was separated, dried (MgSO4) and evaporated to afford a brown oil. The oil was purified by chromatography on silica gel, eluding with dichloromethane, to give 2-amino-5-bromo-3-methylpyrazine as a white solid (0.312 g, 28%), m.p. 51-52 C.; mass spectrum (+ve CI): 188 (M+H)+.

Statistics shows that 3-Methylpyrazin-2-amine is playing an increasingly important role. we look forward to future research findings about 19838-08-5.

Reference:
Patent; Zeneca Limited; US5861401; (1999); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem