Category: 19745-07-4

Electric Literature of 19745-07-4,Some common heterocyclic compound, 19745-07-4, name is 2,5-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 164(S)- -(5-chloropyrazin-2-yl)-3-(2.5-difluoro-4-(methylsulfonyl)phenoxy)-ri.4′-bipiperidinl- -one[00580] A stirred solution of (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-[l,4′- bipiperidin]-2-one (Preparation G; 40 mg, 0.103 mmol), DIEA (90 mu, 0.515 mmol), and 2,5-dichloropyrazine (30.7 mg, 0.206 mmol) in DMF (1 mL) was heated atl00° C in a sealed tube for 2 hours. The mixture was cooled, diluted with EtOAc (25 mL), washed with brine, dried over Na2S04 and concentrated in vacuo. The residue was purified by preparative TLC (EtOAc/ DCM 4: 1) to afford (S)-l’-(5-chloropyrazin-2-yl)-3-(2,5-difluoro-4- (methylsulfonyl)phenoxy)-[l,4′-bipiperidin]-2-one (2 mg, 0.004 mmol, 4percent yield) as a white solid. Mass spectrum (apci) m/z = 501.1 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5-Dichloropyrazine, its application will become more common.

Reference:
Patent; ARRAY BIOPHARMA INC.; AICHER, Thomas Daniel; BENCSIK, Josef Roland; BOYD, Steven Armen; CONDROSKI, Kevin Ronald; FELL, Jay Bradford; FISCHER, John P.; HINKLIN, Ronald Jay; PRATT, Scott Alan; SINGH, Ajay; TURNER, Timothy M.; WO2011/146335; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19745-07-4, name is 2,5-Dichloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2,5-Dichloropyrazine

Step 3: 1,1-Dimethylethyl 7-[(5-chloro-2-pyrazinyl)oxy]-1,2,4,5-tetrahydro-3H-3- benzazepine-3-carboxylate 1,1-Dimethylethyl 7-hydroxy-1, 2, 4, 5-tetrahydro-3H-3-benzazepine-3-carboxylate (Description 3 of WO 02/40471) (182mg, 0.69mmole) was dissolved in dry dimethylformamide (3ml), cooled to 0°C and treated with sodium hydride (60percent in mineral oil, 29mg, 0.72mmole). The mixture was allowed to warm to room temperature over 60 minutes. A solution of 2,5-dichloropyrazine (product of E1, step 2) (112mg, 0.76mmole) in dry dimethylformamide (1 ml) was added and the mixture stirred at room temperature for 2 hours. The mixture was diluted with water (10ml) and extracted with ethyl acetate (x 2). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography eluting with ethyl acetate/pentane (1: 4) to afford the title compound (208mg). MS (ES+) m/e 376 [M+H]+.

The synthetic route of 19745-07-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2005/97778; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 19745-07-4, name is 2,5-Dichloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19745-07-4, Safety of 2,5-Dichloropyrazine

Step C: (S)-3 -(6-(Methylsulfonyl)pyridin-3 -ylamino)- 1 -(piperidin-4- yl)pyrrolidin-2-one (0.076 g, 0.22 mmol) and 2,5-dichloropyrazine (0.054 g, 0.36 mmol) were dissolved in NMP (0.45 mL) and treated with DIEA (0.098 mL, 0.56 mmol). The mixture was stirred at 80 °C overnight and then cooled to ambient temperature. The reaction mixture was partitioned between EtOAc (40 mL) and FLO (20 mL). The mixture was filtered through a 0.45 muiotaeta nylon membrane and the solids were washed with EtOAc and then dried under high vacuum to provide (S)-l-(l-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(6- (methylsulfonyl)pyridin-3-ylamino)pyrrolidin-2-one (0.030 g, 0.067 mmol, 30percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ARRAY BIOPHARMA INC.; AICHER, Thomas Daniel; BENCSIK, Josef Roland; BOYD, Steven Armen; CONDROSKI, Kevin Ronald; FELL, Jay Bradford; FISCHER, John P.; HINKLIN, Ronald Jay; PRATT, Scott Alan; SINGH, Ajay; TURNER, Timothy M.; WO2011/146335; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 19745-07-4, name is 2,5-Dichloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19745-07-4, Quality Control of 2,5-Dichloropyrazine

A solution of 2,5-dichloropyrazine (217 mg, 1.46 mmol), tert-butyl ((3S,4S)-3- hydroxypiperidin-4-yl)carbamate (300 mg, 1.387 mmol) and K2CO3 (575 mg, 2.25 mmol) in DMSO (2.3 mL) was stirred at 90 °C for 12 h, then at room temperature overnight. The reaction was diluted with water (15 mL) and extracted with DCM (3 x 15 mL). The combined organic extracts was washed with brine (15 mL), dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo. The crude was purified by silica chromatography (0-15percent MeOH/DCM) followed by reverse phase chromatography (0 to 98percent MeCN/water). The fractions containing product were combined, concentrated to remove most ACN, diluted with sat. NaHCCb (15 mL) and extracted with DCM (3 x 15 mL). The combined organic extracts was washed with brine (15 mL) and dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo to afford the title compound (180.7 mg, 40percent yield). MS (apci) m/z = 329.2 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 19745-07-4, A common heterocyclic compound, 19745-07-4, name is 2,5-Dichloropyrazine, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2 5-Chloro-2-(1′-piperazinyl)-pyrazine hydrochloride The title compound, m.p. 301°-302°, is prepared similarly to Example 1 by substituting 2,5-dichloropyrazine for 2,6-dichloropyrazine.

The synthetic route of 19745-07-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck & Co., Inc.; US4081542; (1978); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 19745-07-4,Some common heterocyclic compound, 19745-07-4, name is 2,5-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-CYCLOBUTYL-2, 3,4, 5-TETRAHYDRO-1H-BENZO [d] azepin-7-ol (E3) (184 mg, 0.85 MMOL) was dissolved in dry dimethylformamide (3 ml), cooled to 0 °C and treated with sodium hydride (60 percent in mineral oil, 36 mg, 0.89 MMOL). The mixture was allowed to warm to room temperature over 30 minutes. A solution of 2, 5-dichloropyrazine (D47) (139 mg, 0.94 MMOL) in dry dimethylformamide (1 ml) was added and the mixture stirred at room temperature for 5 hours. The mixture was applied to a SCX column and washed with methanol then a mixture of. 880 ammonia/methanol (1: 9). The basic fractions were combined and concentrated in vacuo to afford the title compound (268 mg); MS (ES+) m/e 330 [M+H] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5-Dichloropyrazine, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/56369; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 19745-07-4,Some common heterocyclic compound, 19745-07-4, name is 2,5-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: 2-chloro-5 -(methylsulfanyl)pyrazine: A stirred solution of 2,5 -dichioropyrazine (1.6 g, 11 mmol) in DMF (15 mL) was treated with sodium thiomethoxide (0.8 g, 12 mmol). After 2h,the solution was diluted with brine and extracted with EtOAc. The organic layer was removed, dried over MgSO4, filtered and concentrated giving rise to an oil. The oil was used crude in next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5-Dichloropyrazine, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP; TANG, Haifeng; PIO, Barbara; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; FERGUSON, Ronald Dale, II; GUO, Zack Zhiqiang; CHOBANIAN, Harry; FRIE, Jessica; GUO, Yan; WU, Zhicai; YU, Yang; WANG, Ming; WO2015/17305; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 19745-07-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19745-07-4, name is 2,5-Dichloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2,5-dichloropyrazine 3.0 g, sodium hydride (60percent, oil) 880 ml, and NMP 50 ml was added to 2.3 g of benzyl alcohol under ice-cooling. The reaction mixture was warmed to room temperature and stirred at room temperature for 5 hours. The resulting reaction mixture was added with water and extracted with ethyl acetate. The resulting organic layer was washed with saturated brine, dried over sodium sulfate, concentrated under reduced pressure, and the resulting residue was subjected to silica gel column chromatography to give 3. lg of an intermediate of the following formula 1 .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; ORIMOTO, KOHEI; NOKURA, YOSHIHIKO; NAKAJIMA, YUJI; TANABE, TAKAMASA; KIMURA, TAKAHIRO; (305 pag.)TW2017/26631; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19745-07-4, name is 2,5-Dichloropyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H2Cl2N2

To a suspension of (S)-(2,2-dimethyl-l,3-dioxolan-4-yl)methanol (8.87 g, 67.1 mmol), in Nu,Nu-Dimethylformamide (DMF) (50 mL) stirred under nitrogen at 0C was added cesium carbonate (32.8 g, 101 mmol), the resulting reaction mixture was stirred at 0 C for 1 hr. To this added 2,5-dichloropyrazine (10 g, 67.1 mmol). The resulting reaction mixture was stirred at 100 C for 6 hr. Progress of the reaction was monitored by TLC. TLC indicated starting material was consumed to form new polar spot with 0.3 Rf. The reaction mass was cooled to rt, added water(lOOmL) and extracted with Ethyl acetate(lOOmL). The organic layer was washed with water(100mLX2). The organic layer was dried over Na2S04 and filtered and concentrated to get crude as light brown liquid. The crude product was added to a silica gel (60-120) column and was eluted with Hex/EtOAc. Collected fractions: 30%EtOAc in Hexane the product was eluted. Concentrated the product fractions to afford (S)-2-chloro-5-((2,2-dimethyl-l,3-dioxolan-4-yl)methoxy)pyrazine (12 g, 47.7 mmol, 71.0 % yield) as light brown liquid, LCMS (m/z): 244.90 [M+H]+.

The synthetic route of 19745-07-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ELLIS, James Lamond; EVANS, Karen Anderson; FOX, Ryan Michael; MILLER, William Henry; SEEFELD, Mark Andrew; (766 pag.)WO2016/79709; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 19745-07-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19745-07-4 name is 2,5-Dichloropyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Tris(dibenzylideneacetone)dipalladium(0) (0.123 g, 0.134 mmol), xantphos (0.300 g, 0.503 mmol), potassium carbonate (1 .18 g, 8.39 mmol) and 2-hydroxy-4-methoxy-3-m ethyl- 1 ,2- dihydropyrrol-5-one (0.480 g, 3.36 mmol) were stirred in 1 ,4-dioxane (20 mL), and the 2,5- dichloropyrazine (B, 0.500 g, 3.36 mmol) was added, the purple-red mixture then being warmed to around 80°C with stirring under a nitrogen atmosphere. After 5hr the mixture was cooled, then – – diluted with EtOAc (20ml) and water (10ml) and filtered through celite, washing through with further small portions of EtOAc and water. The organic phase was separated, the aqueous being further extracted with EtOAc (15ml). The organic extracts were combined, washed with water (10ml), dried over MgSO^ and filtered, and the filtrate adsorbed onto silica for chromatography to give a pale cream powder, 627mg (73percent).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,5-Dichloropyrazine, and friends who are interested can also refer to it.