Category: 179323-60-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, A new synthetic method of this compound is introduced below., name: 1-(Pyrazin-2-yl)ethanamine

To a mixture of 5-(isobutyl(methyl)carbamoyl)-4′-methylbiphenyl-3-carboxylic acid (21 mg, 0.064 mmol), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (25 mg, 0.13 mmol), 1-hydroxybenzotriazole hydrate (9.9 mg, 0.064 mmol), and CH2Cl2 (3 mL) were added l-(pyrazin-2- yl)ethanamine (12 mg, 0.097 mmol) and NN-diisopropylethylamine (17 muL, 0.097 mmol). The mixture was stirred at room temperature overnight, and then concentrated in vacuo. The residue was purified by preparative HPLC (100 x 21.2 mm Cl 8 column, 30-70% MeCnu/water[10 mM Et2NH]) to afford a white foam.LC-MS: 431.1 [M+l]+; 1H NMR (400 MHz, CD3OD): (rotamers) delta 8.70 (s, IH), 8.59 (m, IH), 8.49 (d, IH, J = 2.8 Hz), 8.20 (t, IH, J = 1.6 Hz), 7.84-7.75 (m, 2H), 7.62-7.57 (m, 2H), 7.30 (d, 2H, J = 8.0 Hz), 5.36 (q, IH, J = 7.2 Hz), 3.42 (d, IH, J = 7.6 Hz), 3.19 (d, IH, J = 7.6 Hz), 3.10 and 3.01 (s, 3H), 2.39 (s, 3H), 2.15 and 1.98 (m, IH), 1.66 (d, 3H, J = 7.2 Hz), 1.02 and 0.78 (d, 6H, J = 6.4 Hz).

The synthetic route of 179323-60-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RENOVIS, INC.; WO2009/110985; (2009); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 179323-60-5, These common heterocyclic compound, 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3 4′-Methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid-1-pyrazin-2-yl-ethyl)-amideThe 4′-methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid from step 2, together with 1-pyrazin-2-yl-ethylamine (0.2 mL, excess), HOAt (10 mg, catalytic amount), NMM ((0.5 mL) and ECDI (200 mg) were added to DMF (4 mL), and the resulting mixture was stirred overnight at room temperature. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was concentrated under reduced pressure and the resulting residue was purified by preparative thin layer chromatography (5% MeOH in dichloromethane) to give 58 mg (36% yield overall) of 4′-methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid-1-pyrazin-2-yl-ethyl)-amide, MS (M+H)=451.

Statistics shows that 1-(Pyrazin-2-yl)ethanamine is playing an increasingly important role. we look forward to future research findings about 179323-60-5.

Reference:
Patent; Chen, Li; Dillon, Michael Patrick; Feng, Lichun; Yang, Minmin; US2010/324069; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, A new synthetic method of this compound is introduced below., name: 1-(Pyrazin-2-yl)ethanamine

5-(Isobutyryl-methyl-amino)-4′-methyl-biphenyl-3-carboxylic acid methyl ester (67 mg, 0.22 mmol) was added to methylene chloride (3 mL) and stirred at room temperature. TEA (0.87 g), 1-pyrazin-2-yl-ethylamine (32 mg, 0.25 mmol), HOBt (29 mg) and ECDI (54 mg) were added, and the reaction mixture was stirred overnight at room temperature. The reaction mixture was placed directly onto a silica column and eluted with 50% ethyl acetate/hexanes to give 32 mg of 5-(isobutyryl-methyl-amino)-4′-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide as a white solid, MS (M+H)=417.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Broka, Chris Allen; Hawley, Ronald Charles; US2010/324056; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 179323-60-5, These common heterocyclic compound, 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 1 -(pyrazin-2-yl)ethanamine (469.0 g, 3810 mmol) in 2-propanol (1 .9 L) was placed in a 5-L reactor equipped with a mechanical stirrer (glass rod, teflon paddle) and internal thermometer under N2. Ethyl 2-chloropyrimidine-5-carboxylate (71 1 g, 3810 mmol) was added as a solid with stirring followed by DIPEA (640 g, 4950 mmol). The resulting solution was gradually warmed to 88 C, stirred for 7 hrs then allowed to cool. The content of the tank was transferred into a 6-L erlen meyer flask and the tank rinsed with 2-propanol. The solution was concentrated in vacuo to remove approximately half of the volume. The content of the erlenmeyer was transferred into a 10-L tank equipped with a jacket, a short-path distillation set-up connected to a 1 L flask and a mechanical stirrer. The erlenmeyer and the flask were rinsed with water until all the solids have been transferred. The resulting suspension was stirred at 50 C under vacuum for 5 hrs and the mixture then allowed to cool to rt. Water (2 L) was added, the mixture stirred for 2 hrs then the solid was filtered off, washing through with water (500 ml_). The solid was dried in vacuo. The filtrate was concentrated in vacuo and the resulting solid filtered off and dried to provide additional product. This was purified by chiral SFC separation, using a Chiralcel IC-H 50 x 250 column, eluting with 65:35 CO2: MeCN at a flow rate of 250 mL/min, wavelength 215 nm to afford the title compound as a pale orange oil that crystallized on standing, 441 g. RT = 1 .38 min; 1H NMR (400 MHz, CDCI3): delta 1.37 (t, 3H), 1.63 (d, 3H), 4.35 (q, 2H), 5.42 (quint., 1 H), 6.58 (d, 1 H), 8.49 (d, 1 H), 8.54 (dd, 1 H), 8.65 (d, 1 H), 8.85 (br s, 2H). LCMS m/z = 274 [M+H]+

Statistics shows that 1-(Pyrazin-2-yl)ethanamine is playing an increasingly important role. we look forward to future research findings about 179323-60-5.

Reference:
Patent; PFIZER INC.; CASIMIRO-GARCIA, Agustin; STROHBACH, Joseph Walter; HEPWORTH, David; LOVERING, Frank Eldridge; CHOI, Chulho; ALLAIS, Christophe Philippe; WRIGHT, Stephen Wayne; (213 pag.)WO2018/11681; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 179323-60-5,Some common heterocyclic compound, 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2 5-Iodo-4′-methyl-biphenyl-3-carboxylic acid-1-pyrazin-2-yl-ethyl)-amideThe 5-iodo-4′-methyl-biphenyl-3-carboxylic acid from step 1, together with 1-pyrazin-2-yl-ethylamine (0.15 mL, excess), HOAt (10 mg, catalytic amount), NMM (0.4 mL) and EDCI (400 mg) were added to DMF (6 mL). The reaction mixture was stirred overnight at room temperature, then partitioned between water and ethyl acetate. The organic layer was concentrated under reduced pressure and the resulting residue was purified by preparative thin layer chromatography (5% MeOH in dichloromethane) to give 340 mg (95% yield overall) of 5-iodo-4′-methyl-biphenyl-3-carboxylic acid 1-pyrazin-2-yl-ethyl)-amide.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(Pyrazin-2-yl)ethanamine, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(Pyrazin-2-yl)ethanamine

Step B: 2-[1-(Pyrazin-2-yl)ethylamino]-4-[benzimidazol-1-yl]pyrimidine The title compound was prepared from 1-(pyrazin-2-yl)ethylamine according to the procedure outlined in the EXAMPLE 1, Step C. Mass spectrum 318.2 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Merck & Co., Inc.; US6498165; (2002); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem