Category: 17890-77-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17890-77-6, name is 3-Amino-6-bromopyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., Computed Properties of C5H5BrN4O

Step 3: Synthesis of Intermediate D’ as described in the general scheme: 2,5-dibromo-3-amidopyrazine A mixture of C’ (200 g, 922 mM), aq. hydrobromic acid 47% (500 mL) and acetic acid (100 mL) is cooled to -10 C. Bromine (47.25 mL, 922 mM) is then added to the reaction mixture over 45 min at -10 C. A solution of sodium nitrite (190 g, 2.765 M) in water (400 mL) is then added over 2h, whilst maintaining the reaction mixture temperature below -5 C. Upon completion of the addition, the reaction mixture is further stirred for 30 min. A solution of sodium thiosulfate (250 g) in water (712 mL) is then added over 30 min forming a suspension. The solid is isolated by filtration, washed with water (400 mL*2) and dried at 50-55 C. under vacuum to afford crude D’. Crude D’ (186 g) is suspended in a solution of 2-butanone (93 mL) and hexane (279 mL) and then stirred at 30 C. for 1 hr. The solid is isolated by filtration, the cake is washed with a 1:3 mixture of 2-butanone (93 mL) and hexane (186 mL) and dried at 50 C. for 3 hrs to afford clean D’.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian; US2011/118269; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 17890-77-6, These common heterocyclic compound, 17890-77-6, name is 3-Amino-6-bromopyrazine-2-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the equipped with magnetic stirring, of the reflux condensation tube (with drying tail pipe) of 250 ml in three-necked bottle, adding 13.1g (about 0.06 muM) 3 – amino pyrazine -2 – formamide, 60 ml of acetic anhydride, 60 ml ethyl trimethyl orthoformate, stirring under heating to reflux 4h, started when the reflux temperature 136 C, gradually reduced to 95 C, cooling to room temperature, filter, ice laundering, a brown solid.The crude isopropyl alcohol and water (1:1) about 300 ml of mixed the fluid is heavy crystallization, heating completely dissolved, add 2g activated carbon to decolorize 30min, heat filtering, washing. Cooling separating white solid. 60 C drying. Be 11.24g white powder that is 6 – bromo -4 (3H) dihydropteridinones. Yield: 82.5

The synthetic route of 17890-77-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Li Zhulai; (15 pag.)CN106699759; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 17890-77-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17890-77-6 as follows.

To a solution of 3-amino-6-bromopyrazine-2-carboxamide (200 mg, 0.92 mmol) in triethoxymethane (10 mL) was added Ac20 (2 mL). The mixture was stirred at 130C for 1 h and 90C for 3 h. After being cooled to RT and extracted with EtOAc, the combined organic phaseswere basified to pH = 8 with a.q. NaHCO3, washed with brine, dried over Na2504, filtered andevaporated. The crude product was purified by prep-TLC (DCM : MeOH = 50: 1) to give theproduct of 6-bromopteridin-4(3H)-one (100 mg, yield: 48%). ?H-NMR (DMSO-d6, 400 MHz)8.59 (s, 1H), 7.89 (s, 1H). MS (M+H): 227 / 229.

According to the analysis of related databases, 17890-77-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17890-77-6, name is 3-Amino-6-bromopyrazine-2-carboxamide belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 17890-77-6

10 g of 3-amino-6-bromopyrazine-2-carboxamide was added to 120 ml of tetrahydrofuran, 0.1 g of tetrakis(triphenylphosphine)palladium and 12.6 g of sodium carbonate were added, and then 14 g of 3-chloro-5-methyl was added. The phenylboronic acid was heated to reflux for 5 hours and concentrated. Water and ethyl acetate were added to extract and the mixture was separated. The organic phase was collected and concentrated. The residue was separated on a silica gel column to give 7 g of 3-amino-6-(3-chloro-5-methylphenyl)pyrazine-2-carboxamide

The synthetic route of 17890-77-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Changsha Shencheng Biological Technology Co., Ltd.; Bu Gonggaofamingren; (5 pag.)CN107513041; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem