Category: 173290-17-0

Adding a certain compound to certain chemical reactions, such as: 173290-17-0, name is Methyl 3-iodopyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 173290-17-0, SDS of cas: 173290-17-0

3-Iodopyrazine-2-carboxylic acid methyl ester (0.37 g, 1.4 mmol, Reference compound No.15-1), 4-pyridinemethanethiol hydrochloride (0.24 g, 1.5 mmol) and potassium carbonate (0.41 g, 3.0 mmol) were suspended in N,N-dimethylformamide (10 mL), then the mixture was stirred at 60C for 1 hour. The reaction mixture was diluted with ethyl acetate (70 mL), and washed with water (100 mL) twice and brine (70 mL) twice. The ethyl acetate layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The resulting residue was filtered off with diisopropyl ether to give 0.25 g of the title reference compound as a pale cinnabar solid. (Yield 69%)1H-NMR(500MHz,CDCl3)delta 4.03(s,3H),4.37(s,2H),7.35(dd,J = 4.3,1.5 Hz,2H),8.39(d,J = 2.1 Hz,1H), 8.52(dd,J = 4.3,1.5 Hz,2H),8.53(d,J = 2.1 Hz,1H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-iodopyrazine-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; SANTEN PHARMACEUTICAL CO., LTD.; EP1602647; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

173290-17-0, name is Methyl 3-iodopyrazine-2-carboxylate, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H5IN2O2

Example 5 Preparation of Methyl 3-trifluoromethyl-pyrazine-2-carboxylate (8) To methyl 3-iodopyrazine-2-carboxylate (7) (10 g, 37.88 mmol) in DMF (Volume: 300 mL) was added methyl chlorodifluoroacetate (27 g, 0.189 mol), potassium fluoride (13.2 g, 0.227 mol), and copper chloride (22.47 g., 0.227 mol). The reaction was heated at 120 C. for 12 h. The reaction mixture was poured into ethyl ether (1000 ml) and washed with brine (3*300 ml), dried over MgSO4 before the solvent was removed. The residue was loaded onto a silica column and was eluted using ethyl acetate/hexanes gradient to afford the title compound (3.19 g, 41%) as an amber oil: 1H NMR (400 MHz, CDCl3) delta 8.85 (d, J=5.4 Hz, 1H), 8.82 (d, J=5.4 Hz, 1H), 4.05 (s, 3H); EIMS m/z 206.

The synthetic route of 173290-17-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DOW AGROSCIENCES LLC; US2011/301178; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem