Adding a certain compound to certain chemical reactions, such as: 168123-82-8, name is 7-Bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 168123-82-8, COA of Formula: C7H4BrN3O2
General procedure: A mixture of substituted pyridine-2,3-diamine 1 (20 mmol) anddiethyl oxalate(10 mL) was stirred at 100 C for 12 h and cooled toroom temperature subsequently. Ethoxyethane was added toobtain solid. The formed solid was then centrifuged and dried toobtain brown solid compound of pyrido[2,3-b]pyrazine-2,3(1H,4H)-dione 2. The mixture of pyrido[2,3-b]pyrazine-2,3(1H, 4H)-dione and POCl3(20 ml) was stirred at 130 C and then cooled toroom temperature. The mixture was poured into the ice water. Theformed solid was filter and then evaporated solvent in vacuo toobtain unpurified 2,3-dichloropyrido[2,3-b]pyrazine 3. Then theunpurified was mixture with LiOH (10 mmol) in THF/H2O (5:2,35 mL). The mixture was stirred at 65 C for 12 h. The resultingmixture was cooled to room temperature, and then brine (10 mL)was added to mixture. After extraction with THF (3 50 ml), thecombined organic layers were washed with brine (30 mL), dried over anhydrous MgSO4, and filtered, followed by evaporation of thesolvent in vacuo to obtain the unpurified 2-chloropyrido[2,3-b]pyrazin-3(4H)-one 4a-c. The crude products were purified by columnchromatography on silica gel using petroleum ether/EtOAc(3:1) as eluent to provide the desired product 2-chloropyrido[2,3-b]pyrazin-3(4H)-one derivatives4a-c.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione, and friends who are interested can also refer to it.