Category: 160252-31-3

Synthetic Route of 160252-31-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 160252-31-3 name is 1-(5-Chloropyrazin-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: 1-(5-(4-fluoro-1H-pyrazol-1-yl)pyrazin-2-yl)ethan-1-one Sodium hydride (60 wt %, 276 mg, 6.90 mmol) was added to a mixture of 1-(5-chloropyrazin-2-yl)ethanone (800 mg, 5.11 mmol) and 4-Fluoro-1H-pyrazole (484 mg, 5.62 mmol) in N,N-dimethylformamide (6.0 mL) at ambient temperature for 10 minutes. The reaction mixture was then poured into water (70 mL) and was sonicated and stirred for 20 minutes. A dark red solid was isolated by filtration, washed with small amounts of water, and dried to 1-(5-(4-fluoro-1H-pyrazol-1-yl)pyrazin-2-yl)ethan-1-one (919 mg, 95% yield). MS: M+1=207.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(5-Chloropyrazin-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Kim, Joseph L.; Kevin, Douglas J.; Brubaker, Jason D.; (57 pag.)US2017/267661; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 160252-31-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A stirred solution of 2-chloro-4-acetylpyrazine B.I (500 mg, 3.2 mmol) in EtOH (3 ml) was treated with 4-trifluoromethylaniline (619 mg, 3.8 mmol) at room temperature, followed by the addition of 4N HCl in Dioxane (0.32ml). The resulting reaction mixture was stirred at 100 C for 16 hr in a sealed tube. After consumption of the starting material (by TLC), the reaction mixture was concentrated under reduced pressure, and the resulting crude was purified by column chromatography (20% ethyl acetate/ hexane) using silica gel (60-120 mesh) to afford 430 mg (47%) of l-(5-(4-(trifluoromethyl)phenylamino)pyrazin-2-yl)ethanone B.2. 1H-NMR (DMSO- D6, 200 MHz) delta 10.51 (s, INH), 8.73 (d, J = 2 Hz, 1H), 8.31 (d, J = 2 Hz, 1H),7.99 (d, J = IO Hz, 2H), 7.72 (d, J = 8 Hz, 2H), 2.49 (s, 3H). LCMS m/z = 281.9 [M+l].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(5-Chloropyrazin-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; CHUAQUI, Claudio; COSSROW, Jennifer; DOWLING, James; GUAN, Bing; HOEMANN, Michael; ISHCHENKO, Alexey; JONES, John, Howard; KABIGTING, Lori; KUMARAVEL, Gnanasambandam; PENG, Hairuo; POWELL, Noel; RAIMUNDO, Brian; TANAKA, Hiroko; VAN VLOTEN, Kurt; VESSELS, Jeffrey; XIN, Zhili; WO2010/78408; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 160252-31-3, HPLC of Formula: C6H5ClN2O

Sodium hydride (60 wt.%, 276 mg, 6.90 mmol) was added to a mixture of 1- (5-chloropyrazin-2-yl)ethanone (800 mg, 5.11 mmol) and 4-Fluoro-1H-pyrazole (484 mg, 5.62 mmol) in N,N-dimethylformamide (6.0 mL) at ambient temperature for 10 minutes. The reaction mixture was then poured into water (70 mL) and was sonicated and stirred for 20 minutes. A dark red solid was isolated by filtration, washed with small amounts of water, and dried to 1 -(5 -(4-fluoro- 1 H-pyrazol- 1 -yl)pyrazin-2-yl)ethan- 1-one (919 mg, 95% yield). MS: M+1 = 207.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(5-Chloropyrazin-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; BRUBAKER, Jason, D.; DIPIETRO, Lucian, V.; (105 pag.)WO2018/22761; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 160252-31-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Sodium hydride (60 wt.%, 276 mg, 6.90 mmol) was added to a mixture of 1- (5-chloropyrazin-2-yl)ethanone (800 mg, 5.11 mmol) and 4-Fluoro-1H-pyrazole (484 mg, 5.62 mmol) in N,N-dimethylformamide (6.0 mL) at ambient temperature for 10 minutes. The reaction mixture was then poured into water (70 mL) and was sonicated and stirred for 20 minutes. A dark red solid was isolated by filtration, washed with small amounts of water, and dried to 1-(5-(4-fluoro-1H-pyrazol-1-yl)pyrazin-2-yl)ethan-1-one (919 mg, 95% yield). MS: M+1 = 207.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(5-Chloropyrazin-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; BRUBAKER, Jason D.; GUZI, Timothy; WILSON, Kevin J.; DIPIETRO, Lucian V.; ZHANG, Yulian; WILSON, Douglas; FLEMING, Paul E.; (137 pag.)WO2018/17983; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 160252-31-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 160252-31-3 name is 1-(5-Chloropyrazin-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of (4-(3-(cyclopropylmethoxy)phenoxy)-2,6-difluorophenyl)methanol (60 mg), 1-(5-chloropyrazin-2-yl)ethanone (33.7 mg), sodium hydride (60% in oil, 11.75 mg) and THF (1 ml) was stirred at room temperature for 10 min, and then stirred under microwave irradiation at 135C for 1 hr. To the mixture was added water at 0C, and the mixture was extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by HPLC (acetonitrile/water, addition of 0.1% TFA) to give the title compound (20 mg). 1H NMR (300 MHz, CDCl3) delta 0.31-0.42 (2H, m), 0.61-0.70 (2H, m), 1.22-1.30 (1H, m), 2.66 (3H, s), 3.79 (2H, d, J = 7.0 Hz), 5.47 (2H, s), 6.53-6.68 (4H, m), 6.76 (1H, ddd, J = 8.3, 2.4, 0.8 Hz), 7.27-7.34 (1H, m), 8.18-8.23 (1H, m), 8.81-8.88 (1H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(5-Chloropyrazin-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Pharmaceutical Company Limited; MIZOJIRI, Ryo; ASANO, Moriteru; TOMITA, Daisuke; BANNO, Hiroshi; TAWADA, Michiko; NII, Noriyuki; GIPSON, Krista E.; MAEZAKI, Hironobu; TSUCHIYA, Shuntaro; IMAI, Mayumi; AMANO, Yuichiro; (100 pag.)EP3279183; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 160252-31-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 160252-31-3 name is 1-(5-Chloropyrazin-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: 1-(5-(4-fluoro-1H-pyrazol-1-yl)pyrazin-2-yl)ethan-1-one Sodium hydride (60 wt %, 276 mg, 6.90 mmol) was added to a mixture of 1-(5-chloropyrazin-2-yl)ethanone (800 mg, 5.11 mmol) and 4-Fluoro-1H-pyrazole (484 mg, 5.62 mmol) in N,N-dimethylformamide (6.0 mL) at ambient temperature for 10 minutes. The reaction mixture was then poured into water (70 mL) and was sonicated and stirred for 20 minutes. A dark red solid was isolated by filtration, washed with small amounts of water, and dried to 1-(5-(4-fluoro-1H-pyrazol-1-yl)pyrazin-2-yl)ethan-1-one (919 mg, 95% yield). MS: M+1=207.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(5-Chloropyrazin-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Kim, Joseph L.; Kevin, Douglas J.; Brubaker, Jason D.; (57 pag.)US2017/267661; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H5ClN2O

A mixture of (4-(3-(cyclopropylmethoxy)phenoxy)-2-fluorophenyl)methanol (200 mg), 1-(5-chloropyrazin-2-yl)ethanone (119 mg), sodium hydride (60% in oil, 41.6 mg) and THF (1 ml) was stirred at room temperature for 10 min, and heated under microwave irradiation at 100C for 1 hr. To the mixture was added water at 0C, and the mixture was extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (65 mg). 1H NMR (300 MHz, CDCl3) delta 0.27-0.39 (2H, m), 0.60-0.69 (2H, m), 1.19-1.31 (1H, m), 2.66 (3H, s), 3.77 (2H, d, J = 6.9 Hz), 5.48 (2H, s), 6.57-6.65 (2H, m), 6.68-6.86 (3H, m), 7.19-7.29 (1H, m), 7.43 (1H, t, J = 8.4 Hz), 8.23 (1H, d, J = 1.2 Hz), 8.83 (1H, d, J = 1.3 Hz).

According to the analysis of related databases, 160252-31-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; MIZOJIRI, Ryo; ASANO, Moriteru; TOMITA, Daisuke; BANNO, Hiroshi; TAWADA, Michiko; NII, Noriyuki; GIPSON, Krista E.; MAEZAKI, Hironobu; TSUCHIYA, Shuntaro; IMAI, Mayumi; AMANO, Yuichiro; (100 pag.)EP3279183; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 160252-31-3, A common heterocyclic compound, 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone, molecular formula is C6H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-(5-Chloropyrazin-2-yl)ethanone (2.8 g, 17.9 mmol) was dissolved in DMF (30 mL) and CF3CH2OH was added followed by the addition of NaH (1.07 g, 26.8 mmol, 60% dispersion) at 0 C. The mixture was stirred at 0 C. for 10 min. The reaction was quenched with sat. NH4Cl, extracted with EtOAc, dried over MgSO4, and evaporated. The crude material was purified by flash column (50 g SNAP, 8-20% EtOAc in hexane) to afford the title compound. LC/MS (m/z): 221 (M+H)+

The synthetic route of 160252-31-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme Corp.; Berger, Richard; Blizzard, Timothy A.; Campbell, Brian T.; Chen, Helen Y.; Debenham, John S.; Dewnani, Sunita V.; Dubois, Byron; Gude, Candido; Guo, Zack Zhiqiang; Harper, Bart; Hu, Zhiyong; Lin, Songnian; Liu, Ping; Wang, Ming; Ujjainwalla, Feroze; Xu, Jiayi; Xu, Libo; Zhang, Rui; (64 pag.)US2018/9796; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 160252-31-3, These common heterocyclic compound, 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 1-(5-chloropyrazin-2-yl)ethanone in ethanol (25 mL) was added to a solution of sodium ethoxide in ethanol at 0 C. The reaction mixture turned into a yellowish brown slurry. After it was stirred at 0 C. for 1 h, the reaction was quenched with saturated aqueous NH4Cl. The mixture was extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography (0-30% EtOAc/hexanes) to give the title compound

The synthetic route of 160252-31-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme Corp.; Berger, Richard; Blizzard, Timothy A.; Campbell, Brian T.; Chen, Helen Y.; Debenham, John S.; Dewnani, Sunita V.; Dubois, Byron; Gude, Candido; Guo, Zack Zhiqiang; Harper, Bart; Hu, Zhiyong; Lin, Songnian; Liu, Ping; Wang, Ming; Ujjainwalla, Feroze; Xu, Jiayi; Xu, Libo; Zhang, Rui; (64 pag.)US2018/9796; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem