Category: 15986-92-2

Reference of 15986-92-2,Some common heterocyclic compound, 15986-92-2, name is 5,6-Dimethyl-2,3-dihydropyrazine, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5, 6-dimethyl-2, 3-dihydropyrazine (2.3 g, 21 mmol) in absolute ethanol (60 mL) was added sodium metal (6.5 g, 280 mmol) in small portions over a 3 hour period. The resulting mixture was heated to reflux. After 3 hours at reflux, the product was distilled from the mixture while 200 mL of water was added gradually to reaction vessel. The distillate was treated with 1 N aqueous HCI solution and concentrated in vacuo to afford a semi-solid. Titration with acetone afforded 0.78 g (20% yield) of (trans)-2, 3- dimethylpiperazine, a compound of formula (Gb), as an orange solid ; NMR (DMSO-d6) 9.8 (br s, 4), 3.5- 3.2 (m, 6), 1.2 (s, 6) ppm.

The synthetic route of 15986-92-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING AKTIENGESELLSCHAFT; HORUK, Richard; WO2005/79769; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 15986-92-2, name is 5,6-Dimethyl-2,3-dihydropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15986-92-2, SDS of cas: 15986-92-2

A. To a solution of 5,6-dimethyl-2,3-dihydropyrazine (2.3 g, 21 mmol) in absolute ethanol (60 mL) was added sodium metal (6.5 g, 280 mmol) in small portions over a 3 hour period. The resulting mixture was heated to reflux. After 3 hours at reflux, the product was distilled from the mixture while 200 mL of water was added gradually to reaction vessel. The distillate was treated with 1 N aqueous HCl solution and concentrated in vacuo to afford a semi-solid. Titration with acetone afforded 0.78 g (20% yield) of (trans)-2,3-dimethylpiperazine, a compound of formula (Gb), as an orange solid; NMR (DMSO-d6) 9.8 (br s, 4), 3.5-3.2 (m, 6), 1.2 (s,6) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dimethyl-2,3-dihydropyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Schering Aktiengesellschaft; US6207665; (2001); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem