Category: 15707-23-0

15707-23-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15707-23-0 as follows.

Ag2O (23.2 mg, 0.1 mmol), 3-nitro-1,2-benzenedicarboxylicacid (H2npt) (42.2 mg, 0.2 mmol) and epyz (24.4 mg, 0.2 mmol) were dissolved in methanol-H2O-DMF mixed solvent (6 mL,v/v/v = 1/1/1) in the presence of ammonia (0.5 mL, 14 M) underultrasonic treatment (160 W, 40 kHz, 30 min) under 40 C. Theresultant colorless solution was allowed slowly to evaporate atroom temperature in the dark. After several days, colorless platecrystals of 1 were isolated in about a 43% yield. They were washedwith a small volume of cold ethanol. Anal. Calc. for Ag2C15H13N3O6:C, 32.94; H, 2.40; N, 7.68. Found: C, 32.98; H, 2.38; N, 7.72%. IR(KBr): m (cm1) = 3440 (m), 3088 (w),3046 (w), 2976 (m),2932(w), 2876 (w), 1590 (s), 1520 (s), 1457(s), 1408 (s), 1344 (s),1288 (m), 1162 (m), 1027 (w), 929 (m), 859 (m), 824 (m), 782(w), 747 (w), 704 (m), 683 (m), 586 (w).

According to the analysis of related databases, 2-Ethyl-3-methylpyrazine, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Ting; Wang, Dan-Feng; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; vol. 427; (2015); p. 299 – 304;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 15707-23-0, name is 2-Ethyl-3-methylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15707-23-0, Computed Properties of C7H10N2

A mixture of 2-methyl-3-ethylpyrazine (22.35g, 183mmol), selenium dioxide (30g, 270mmol), and diatomaceous earth (30g) in dioxane (250ml) was heated at reflux for 18 hours. The mixture was allowed to cool and the solid material removed by filtration through diatomaceous earth. The filter pad was washed with methanol several times and the volatiles removed from the combined filtrate by evaporation. The residue was purified by chromatography on silica gel eluting eluting with EtOAC/hexanes (0:100 increasing in polarity tol5:85) to give 3-ethylpyrazine-2-carboxaldehyde (3.Og, 12%); NMR Spectrum 1.22 (t, 3H), 3.19 (q, 2H), 8.78 (s, IH), 8.80 (s, IH), 10.10 (s, IH).

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Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/106307; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

15707-23-0, name is 2-Ethyl-3-methylpyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-Ethyl-3-methylpyrazine

In an air atmosphere, a nitrogen-containing heterocyclic compound 2e (13.2 mg, 0.1 mmol),Pentamethylcyclopentadienyl iridium (III) chloride dimer (2.0mg), Bistrifluoromethanesulfonimide silver salt (5.8mg), Lithium carbonate (14.8mg) and silver acetate (33.4mg),Use a syringe to inject a 1,2-dichloroethane solution (1.0 mL) containing the alkyne compound 3c (85.6 mg, 0.2 mmol) into the reactor and place the reaction at 120 C for 24 hours.The end of the reaction was determined by thin layer chromatography,The reaction solution was filtered through diatomaceous earth, and then concentrated by spinning with 400 mesh silica gel to prepare a dry powder.The reaction product was separated by column chromatography, 5 g of 400 mesh silica gel,The developing agent is a petroleum ether and ethyl acetate with a volume ratio of 100: 1 to 20: 1 to obtain an alkynyl-containing nitrogen-containing heterocyclic derivative 2-methyl-3-(4-(triisopropylsilyl)-3-butyn-1-yl)pyrazine (1e), 22.0 mg, purity 95%, yield 73%

The synthetic route of 15707-23-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong University of Technology; Li Xianwei; Rao Jianxing; (22 pag.)CN110256480; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 15707-23-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15707-23-0, name is 2-Ethyl-3-methylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

In a 1000 ml three-necked flask, 30.0 g of 2-ethyl-3-methylpyrazine (content 99%), 0.82 g of ferric chloride (n/n: 50:1),0.92 g of 1,10-phenanthroline (n/n: 50:1), 14.8 g of propionic acid and 145 g of t-butanol peroxide, stirred with a magnetic stirrer,The mixture was heated to an internal temperature of 65 to 75 C, and the reaction was terminated after 24 hours, and distilled under reduced pressure to obtain 2-acetyl-3-methylpyrazine.The conversion of 2-ethyl-3-methylpyrazine was 48.75%, and the selectivity of 2-acetyl-3-methylpyrazine was 95.88%.

The synthetic route of 2-Ethyl-3-methylpyrazine has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 15707-23-0, name is 2-Ethyl-3-methylpyrazine, molecular formula is C7H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Ethyl-3-methylpyrazine

A mixture of 2-methyl-3-ethylpyrazine (22.35g, 183mmol), selenium dioxide (30g, 270mmol), and diatomaceous earth (30g) in dioxane (250ml) was heated at reflux for 18 hours. The mixture was allowed to cool and the solid material removed by filtration through diatomaceous earth. The filter pad was washed with methanol several times and the volatiles removed from the combined filtrate by evaporation. The residue was purified by chromatography on silica gel eluting with EtOAc/hexanes (0:100 increasing in polarity tol5:85) to give 3-ethylpyrazine-2-carboxaldehyde (3.0g, 12%); NMR Spectrum 1.22 (t, 3H), 3.19 (q, 2H), 8.78 (s, IH), 8.80 (s, IH), 10.10 (s, IH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15707-23-0, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/100461; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 15707-23-0, name is 2-Ethyl-3-methylpyrazine, molecular formula is C7H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H10N2

EXAMPLE II Preparation Of (R,S)-2-(2-Hydroxy-2-phenylethyl)-3-ethylpyrazine A reaction of 2-ethyl-3-methylpyrazine (12.2 g, 0.01 mole) with benzaldehyde (10.6 g, 0.1 mole) is conducted in accordance with the procedure of Example I. Workup followed by bulb-to-bulb distillation (155C oven/0.02 mm Hg) provides 18.2 g of a light yellow colored oil. This material crystallizes on trituration with hexane, giving 17.80 g (78%) of desired product, mp 52-53C. An analytical sample is obtained by recrystallization from hexane: mp 53-54C; 1H NMR (CDCl3) delta 1.25 (t, 3H, J = 7.4 Hz), 2.77 (q, 2H, J = 7.4 Hz), 3.16 (d, 2H, J = 6.2 Hz), 5.01 (d, 1H, J = 2.5 Hz), 5.28 (m, 1H), 7.27-7.46 (m, 5H), 8.33 (d, 1H, J = 2.8 Hz), 8.40 (d, 1H, J = 2.8 Hz). Anal. Calc. for C14H16N2O: C,73.65; H,7.06; N,12.27 Found: C,73.73; H,7.01; N,12.31

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15707-23-0, its application will become more common.

Reference:
Patent; Philip Morris Products Inc.; EP309203; (1990); A3;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

15707-23-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15707-23-0 as follows.

Ag2O (23.2 mg, 0.1 mmol), 3-nitro-1,2-benzenedicarboxylicacid (H2npt) (42.2 mg, 0.2 mmol) and epyz (24.4 mg, 0.2 mmol) were dissolved in methanol-H2O-DMF mixed solvent (6 mL,v/v/v = 1/1/1) in the presence of ammonia (0.5 mL, 14 M) underultrasonic treatment (160 W, 40 kHz, 30 min) under 40 C. Theresultant colorless solution was allowed slowly to evaporate atroom temperature in the dark. After several days, colorless platecrystals of 1 were isolated in about a 43% yield. They were washedwith a small volume of cold ethanol. Anal. Calc. for Ag2C15H13N3O6:C, 32.94; H, 2.40; N, 7.68. Found: C, 32.98; H, 2.38; N, 7.72%. IR(KBr): m (cm1) = 3440 (m), 3088 (w),3046 (w), 2976 (m),2932(w), 2876 (w), 1590 (s), 1520 (s), 1457(s), 1408 (s), 1344 (s),1288 (m), 1162 (m), 1027 (w), 929 (m), 859 (m), 824 (m), 782(w), 747 (w), 704 (m), 683 (m), 586 (w).

According to the analysis of related databases, 2-Ethyl-3-methylpyrazine, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Ting; Wang, Dan-Feng; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; vol. 427; (2015); p. 299 – 304;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15707-23-0, name is 2-Ethyl-3-methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., 15707-23-0

[0239] A mixture of 2-methyl-3-ethylpyrazine (1.0 g, 8.19mmol), selenium dioxide (1.8 g, 16.38 mmol), and diatomaceous earth (1.8 g) in dioxane (20ml) was refluxed for overnight. The mixture was allowed to cool to room temperature. The solid material was removed by filtration through diatomaceous earth. The solvent was evaporated under reduced pressure. The crude product was washed with water (3 x 10 ml), extracted with ethyl acetate (3 x 20 ml), dried with Na2S04 and concentrated. The crude product was used directly for the next step reaction without purification. LC/MS = 137 [M+l].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUANG, Rongze; TING, Pauline; ALI, Amjad; WU, Heping; BERLIN, Michael; STAMFORD, Andrew; WANG, Hongwu; ZHOU, Gang; KIM, David; DENG, Qiaolin; LIM, Yeon-Hee; YU, Younong; (201 pag.)WO2016/81290; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem