Category: 14667-55-1

These common heterocyclic compound, 14667-55-1, name is 2,3,5-Trimethylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2,3,5-Trimethylpyrazine

General procedure: An equimolecular mixture of 2,3-dimethylpyrazine (0.46 mmol, 50 mg) and 3,5-dichlorosalicylic acid (0.46 mmol, 95.8 mg) was dissolved in 15 mL ethanol at room temperature and stirred for about 30 min, followed by filtrating and slow evaporation. Colorless block-like crystals were obtained within 2 weeks with the total yield of 23.3%. IR (KBr pellet, cm-1): 3456, 3084, 2856, 2423, 1669, 1580, 1441, 1358, 1313, 1225, 1169, 1008, 875, 803, 742, 697, 608, 553. The colorlessblock-like crystal of cocrystal 2 and colorless needle crystals of cocrystal 3 were obtained in the similar way as cocrystal 1, but utilized 2,5-DMP and TMP instead of 2,3-DMP, with the total yield of 30.2% and 25.2%, respectively. IR (KBr pellet, cm-1) for cocrystal 2: 3445, 3079, 2868, 2402, 1669, 1586, 1447, 1363, 1308, 1225, 1175, 1053, 880, 803, 753, 692, 608, 558. IR (KBr pellet, cm-1) for cocrystal 3: 3445, 3073, 2935, 2402, 1669, 1586, 1441, 1391, 1352, 1285, 1241, 1175, 1024, 886, 708, 603, 558.

The synthetic route of 2,3,5-Trimethylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Ya-an; Yan, Cui-Min; Chen, Chen; Zhao, Xiao-Qing; Li, Tian; Sun, Bai-Wang; Research on Chemical Intermediates; vol. 45; 11; (2019); p. 5745 – 5760;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 14667-55-1, A common heterocyclic compound, 14667-55-1, name is 2,3,5-Trimethylpyrazine, molecular formula is C7H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

AgNO3 (34.2 mg, 0.2 mmol), tpyz (38 ml, 0.2 mmol) and H2L(313.6 mg, 0.2 mmol) were took place in CH3CN-DMF (N,Ndimethylformamide)mixed solvent (6 ml, v/v: 3/3) under stirring.Then, ammonia (14 M, 10 d) was dropped into the mixture to give aclear solution under ultrasonic treatment (160 W, 40 KHz, 30 min) atroom temperature. The resultant solution was allowed to evaporateslowly in darkness at room temperature for several days to giveirregular-yellow crystals of 1 (Yield: 32%, based on Ag). Anal. Calc.(found) for Ag2C17H23N2O4: C, 38.10 (38.16); H, 4.50 (4.33); O,11.86 (11.96); N, 5.32 (5.24) %. IR (KBr): nu(cm -1) = 3425 (s), 2977(m), 2887 (w), 2175 (w), 1653 (m), 1545 (s), 1463 (m), 1392 (s),1363 (s), 1322 (m), 1288 (m), 1207(w), 1170 (w), 1126 (w), 1085(w), 997 (w), 919 (w), 804 (m), 628 (s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 14667-55-1, A common heterocyclic compound, 14667-55-1, name is 2,3,5-Trimethylpyrazine, molecular formula is C7H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A reaction mixture of AgNO3 (33.4 mg, 0.2 mmol), 2,3,5-trimethylpyrazine(tpyz) (24.2 mg, 0.2 mmol) and 2-nitroterephthalic acid (H2ntph) (42.2 mg, 0.2 mmol) and H2O (10 mL) was stirred for 30 min in air, then transferred and sealed in a 25 mL Teflon-linedstainless steel autoclave, which was heated to 100 C for 72 h. Aftercooling to room temperature, the resulting colorless prism crystals were washed with distilled water and dried in air. Yield based on silver is 68.72%. Elemental analysis: Anal. calc. (found) for AgC15H13N3O6:C, 39.95(41.00); H, 2.99 (2.96); N, 9.52 (9.57) %. IR (KBr, cm-1) data: 3275 (m), 3093 (w), 2922 (w), 2867 (w), 1707 (s), 1600 (vs), 1527 (vs),1396 (s), 1350 (s), 1292 (s), 1154 (m), 766 (m), 703 (m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Yang, Yuan-Yuan; Zhou, Lin-Xia; Zheng, Yue-Qing; Zhu, Hong-Lin; Li, Wen-Ying; Journal of Solid State Chemistry; vol. 253; (2017); p. 211 – 218;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 14667-55-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14667-55-1 as follows.

General procedure: AgNO3 (34.2 mg, 0.2 mmol), tpyz (38 ml, 0.2 mmol) and H2L(313.6 mg, 0.2 mmol) were took place in CH3CN-DMF (N,Ndimethylformamide)mixed solvent (6 ml, v/v: 3/3) under stirring.Then, ammonia (14 M, 10 d) was dropped into the mixture to give aclear solution under ultrasonic treatment (160 W, 40 KHz, 30 min) atroom temperature. The resultant solution was allowed to evaporateslowly in darkness at room temperature for several days to giveirregular-yellow crystals of 1 (Yield: 32%, based on Ag).

According to the analysis of related databases, 14667-55-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Huang, Hua-Qi; Cheng, Xiao-Yue; Zhang, Ting; Huang, Rong-Bin; Inorganic Chemistry Communications; vol. 68; (2016); p. 21 – 28;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 14667-55-1, name is 2,3,5-Trimethylpyrazine, molecular formula is C7H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H10N2

Example 10 [00650] Preparation of Cpd 76 [00651] The bromoketone intermediate obtained in Step C, Example 6 (855 mg, 3.0 mmol) was mixed with 2,3,5-trimethylpyrazine (402 mg, 3.3 mmol) and acetonitrile (10.0 mL) in a sealed tube. The mixture was stirred at 80 C for 4 hr and cooled to room temperature, followed by the addition of triethylamine (1.3 mL, 9.0 mmol). After stirring for 0.5 hours at room temperature, the mixture was stirred at 60 C overnight. The solvent was removed on a rotovap and the residue was chromatographed (silica gel, ethylacetate in dichloromethane 30%) to provide the intermediate, 3-(l,3-dimethylpyrrolo[l,2-a]pyrazin-7-yl)-7-fluoro-lH-isochromen-l- one (782 mg, 85%). MS m/z 309.3 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 14667-55-1, its application will become more common.

Reference:
Patent; PTC THERAPEUTICS, INC.; CHEN, Guangming; DAKKA, Amal; KARP, Gary Mitchell; LI, Chunshi; NARASIMHAN, Jana; NARYSHKIN, Nikolai; WEETALL, Maria L.; WELCH, Ellen; ZHAO, Xin; WO2013/112788; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem