Category: 1458-03-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1458-03-3, name is Methyl 3-amino-6-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H6ClN3O2

(b) Methyl 2-amino-5-chloropyrazine-3-carboxylate (3.75 g) was added to a solution of sodium hydroxide (2.0 g) in water (20 ml) and the solution was heated under reflux for 1.5 hours. The reaction mixture was cooled to 0 C. and the precipitate which had formed was collected by filtration. The solid was redissolved in water (60 ml) with heating and the solution was filtered. The filtrate was then acidified to pH 2 with 2M hydrochloric acid. The precipitate which formed was collected by filtration and washed with ice/water (2*20 ml) and dried under vacuum. The solid was suspended in diphenyl ether (15 ml) and heated at reflux under an argon atmosphere for 15 minutes. The reaction mixture was cooled to ambient temperature and diluted with hexane (15 ml). The precipitate which formed was collected by filtration and washed with hexane (3*25 ml) to give 2-amino-5-chloropyrazine (1.78 g); 1 H NMR (d6 -DMSO): 6.55 (br s, 2 H), 7.67 (d, 1 H), 7.95 (d, 1 H); mass spectrum (+ve CI): 130 (M+H)+.

According to the analysis of related databases, 1458-03-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zeneca Limited; US5866568; (1999); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A common heterocyclic compound, 1458-03-3, name is Methyl 3-amino-6-chloropyrazine-2-carboxylate, molecular formula is C6H6ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1458-03-3.

Into a 500 ml three-necked flask, 100 mL of acetic acid was added, and Compound 2 (20 g, 0.11 mol) was added dropwise to a 100 mL aqueous solution of 40% hydrogen bromide at 0C. The reaction was completed after 30 minutes of dropwise addition. A 50 ml aqueous solution of sodium nitrite (20.7 g, 0.33 mol) was added dropwise at a controlled temperature of 0C. After 30 minutes of reaction, the reaction is complete and it is quenched by the dropwise addition of 30 ml of 10% sodium bisulfite solution. Ethyl acetate extraction (200ml¡Á2), dried over 20g of anhydrous sodium sulfate, The mixture was concentrated by suction filtration to obtain a white solid compound 3 (23.3 g, yield 87%).

The synthetic route of Methyl 3-amino-6-chloropyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shaoyuan Science And Technology (Shanghai) Co., Ltd.; Shanghai Shaoyuan Reagent Co., Ltd.; Wei Yuanbo; Guo Tao; Wu Yong; (8 pag.)CN108101857; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem