Category: 144692-85-3

Adding a certain compound to certain chemical reactions, such as: 144692-85-3, name is 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144692-85-3, COA of Formula: C6Cl2N2O3

Under nitrogen, 25ml single neck flask was added 2,3-dichloro-o-pyrazine dicarboxylic anhydride 145 (2.8mmol), cyclohexylamine hydrochloride (4.8mmol), or n-butylamine hydrochloride (4.8mmol), and 5ml of acetic anhydride, the reaction at 120 1.5h, TLC showed the reaction was complete, the reaction was poured into water, solid precipitated, suction filtration, the solid was separated by column chromatography to give a white product.2,3-dichloro-6-cyclohexyl–5H- pyrrolo [3,4-b] pyrazine -5,7 (6H) – dione 146a, yield 67%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Capital Normal University; Liao, Yi; Zhu, Rui; Tong, Linlin; Guo, Zhangbin; (14 pag.)CN105669704; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 144692-85-3, name is 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione

Under air, a test tube was charged with 2,3-dichlorodiazaphthalic anhydride (400mg, 1.826mmol) and 2-bromoethylamine hydrobromide (384mg, 1.872mmol). Acetic anhydride (400muL) was added and the reaction sealed and heated to 120C for 30min. The reaction was cooled to ambient temperature and diluted with H2O (2mL). The crude solid was filtered and washed with H2O (2¡Á5mL) and purified by eluting through a plug (SiO2; CH2Cl2) to obtain the product as a mixed halo compound, which was used without further purification. Yield=417mg. Compound 5b was obtained as an approximately 1:1 mixture of the dichloro- and bromochloro- diazaphthalimide as a result of the ammonium counter anion becoming partially exchanged into the pyrazine ring. Attempts to prevent this halide exchange using excess NH4Cl yielded significant amounts of inseparable 5a as a side-product. Nevertheless, 5b was reacted on as the mixed halide species with no significant impact on the subsequent synthesis of 1b (vide supra). (0024) 1H NMR (500MHz, CDCl3): delta 4.24 (t, 3JHH=6.4, 2H, CH2), 4.23 (t, 3JHH=6.4, 2H, CH2), 3.67 (t, 3JHH=6.4, 2H, CH2), 3.66 (t, 3JHH=6.4, 2H, CH2). 13C{1H} NMR (126MHz, CDCl3): delta 162.0, 161.9, 161.8, 161.8, 156.4, 154.1, 150.3, 147.4, 143.9, 143.7, 143.7, 143.4, 40.2, 40.2, 27.7, 27.7. HR ESI-MS positive ion: 379.9013m/z [C8H4BrCl2N3O2+Na+MeOH]+ (calc. 379.8995), 423.8489m/z [C8H4Br2ClN3O2+Na+MeOH]+ (calc. 423.8492). Anal. Calcd for C8H4Br1.5Cl1.5N3O2 (347.17gmol-1): C, 27.68; H, 1.16; N, 12.10. Found: C, 28.34; H, 0.92; N, 11.26; error <0.9%. Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 144692-85-3. Reference:
Article; Knighton, Richard C.; Chaplin, Adrian B.; Tetrahedron; vol. 73; 31; (2017); p. 4591 – 4596;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 144692-85-3, name is 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione

Under air, a test tube was charged with 2,3-dichlorodiazaphthalic anhydride (410mg, 1.872mmol) and 2-chloroethylamine hydrochloride (223mg, 1.919mmol). Acetic anhydride (400muL) was added and the reaction sealed and heated to 120C for 30min. The reaction was cooled to ambient temperature and diluted with H2O (2mL). The crude solid was filtered and washed with H2O (2¡Á5mL) and then purified by eluting through a plug (SiO2; CH2Cl2) to afford analytically pure 5a as a white solid. Yield=391mg (75%). (0022) 1H NMR (500MHz, CDCl3): delta 4.18 (t, 3JHH=6.1, 2H, CH2), 3.83 (t, 3JHH=6.1, 2H, CH2). 13C{1H} NMR (126MHz, CDCl3): delta 161.9, 154.1, 143.4, 40.5, 40.4. HR ESI-MS positive ion: 333.9521m/z [M+Na+MeOH]+ (calc. 333.9523). Anal. Calcd for C8H4Cl3N3O2 (280.49gmol-1): C, 34.26; H, 1.44; N, 14.98. Found: C, 34.33; H, 1.38; N, 14.96.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Knighton, Richard C.; Chaplin, Adrian B.; Tetrahedron; vol. 73; 31; (2017); p. 4591 – 4596;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 144692-85-3, name is 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Formula: C6Cl2N2O3

To a solution of 5b (100mg, ca. 31mumol) and 4 (111mg, 10.2mumol) in dry DMF (5mL) was added DiPEA (91muL, 51.2mumol). The reaction was then stirred at 40C for 36h. The solvent was removed in vacuo and subsequently co-evaporated with toluene (3¡Á2mL). The crude material was purified by gradient column chromatography (SiO2; CH2Cl2/EtOAc 100:0?95:5) to afford analytically pure 1b as a white solid. Yield=95mg (59%). (0016) 1H NMR (500MHz, CDCl3): delta 8.17 (s, 4H, ArH), 7.92-7.94 (m, 4H, ArH), 7.45-7.49 (m, 4H, ArH), 7.23 (s, 4H, ArH), 5.65 (t, 3JHH=8.0, 2H, ArCH), 5.53 (t, 3JHH=8.4, 2H, ArCH), 4.12 (t, 3JHH=6.3, 4H, CH2), 3.46 (t, 3JHH=6.3, 4H, CH2), 2.21-2.31 (m, 8H, CHCH2), 1.25-1.50 (m, 32H, CH2), 0.90-0.95 (m, 12H, CH3). 13C{1H} NMR (126MHz, CDCl3): delta 162.2, 158.5, 153.1, 152.2, 141.5, 139.8, 136.8, 135.6, 129.7, 128.4, 123.8, 118.8, 39.8, 34.4, 32.7, 32.4, 32.0, 29.5, 29.5, 28.1, 27.8, 22.8, 14.2. HR ESI-MS positive ion: 1603.4086m/z [M+Na]+ (calc. 1603.4212). Anal. Calcd for C84H80Br2N10O12 (1581.43gmol-1): C, 63.80; H, 5.10; N, 8.86. Found: C, 63.83; H, 5.01; N, 8.80.

The synthetic route of 144692-85-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Knighton, Richard C.; Chaplin, Adrian B.; Tetrahedron; vol. 73; 31; (2017); p. 4591 – 4596;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 144692-85-3, name is 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144692-85-3, Safety of 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione

Under nitrogen, 25ml single neck flask was added 2,3-dichloro-o-pyrazine dicarboxylic anhydride 145 (2.8mmol), cyclohexylamine hydrochloride (4.8mmol), or n-butylamine hydrochloride (4.8mmol), and 5ml of acetic anhydride, the reaction at 120 1.5h, TLC showed the reaction was complete, the reaction was poured into water, solid precipitated, suction filtration, the solid was separated by column chromatography to give a white product.2,3-dichloro-6-cyclohexyl–5H- pyrrolo [3,4-b] pyrazine -5,7 (6H) – dione 146a, yield 67%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Capital Normal University; Liao, Yi; Zhu, Rui; Tong, Linlin; Guo, Zhangbin; (14 pag.)CN105669704; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem