Adding a certain compound to certain chemical reactions, such as: 1435953-98-2, name is 5-Methoxy-3-methylpyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435953-98-2, category: Pyrazines
l,l’-Thiocarbonyldiimidazole (226 mg, 1.21 mmol) and then hydrochloric acid in dioxane (0.55 mL, 2.2 mmol, 4 mol/L) were added to a solution of 5-methoxy-3-methyl-pyrazin-2-amine (153 mg, 1.10 mmol) in DCM (5.5 mL) under air. The reaction was stirred at r.t. for 4 hours, filtered and the solid washed with DCM (2 x 10 mL). The filtrate was concentrated in vacuo and purified by flash column chromatography on silica (gradient elution with 0% to 100% EtOAc in isohexanes) to give the title compound (127 mg, 40 % Yield). A few drops of isobutylamine were added to the LCMS sample of the product before analysis LCMS [M+H]+ 255, RT 1.46 minutes [M = l-isobutyl-3-(5-methoxy-3- methyl-pyrazin-2-yl)thiourea] (Method 4).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methoxy-3-methylpyrazin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; UCB BIOPHARMA SRL; CHOVATIA, Prafulkumar Tulshibhai; CONNELLY, Rickki Lee; FRANKLIN, Richard Jeremy; HASLETT, Gregory William; HENRY, Alistair James; MADDEN, James; NEUSS, Judi Charlotte; NORMAN, Timothy John; PHILPS, Oliver; PITT, William Ross; RAMPALAKOS, Konstantinos; SELBY, Matthew Duncan; SELVARATNAM, Suganthan; TRANI, Giancarlo; ZHU, Zhaoning; (768 pag.)WO2019/243550; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem