Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13924-99-7, name is 6-Oxo-1,6-dihydropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4N2O3
Example 68. Formula II: R1 =CH3; R2 =R3 =H; R4 =OCH3 To 0.42 g (0.003 mol) of 6-hydroxy-pyrazinoic acid suspended in 10 mL of anhydrous methanol was added 4 mL of (0.030 mol) of chlorotrimethylsilane. The resultant mixture was allowed to stir for 48 hours at room temperature during which time the suspension became a solution. It is expected that this procedure may be used to convert 6-hydroxypyrazinoic acid to any 6-alkoxypyrazinoic ester by the use of the appropriate alcohol and, when the alcohol is not a liquid, the use of an inert solvent such as THF. The solvent and excess chlorotrimethylsilane were removed in vacuo by rotary evaporation. The crude product was purified by column chromatography on silica gel with a hexane-ethyl acetate gradient to yield 0.11 g (22%) of methyl 6-methoxypyrazinecarboxylate.
The synthetic route of 13924-99-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Research Foundation of State University of NY; US5643912; (1997); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem