Category: 1379338-74-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines

Intermediate 37: 1,1-dimethylethyl 3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-4,4-difluoro-1-piperidinecarboxylate (Isomer 2) 5,7-Dichloropyrido[3,4-b]pyrazine (620 mg, 3.10 mmol) was dissolved in N-methyl-2-pyrrolidinone (NMP) (5 mL) and to this was added DIPEA (0.601 mL, 4.65 mmol) and 1,1-dimethylethyl 3-(aminomethyl)-4,4-difluoro-1-piperidinecarboxylate (776 mg, 3.10 mmol). This was heated in a microwave at 130 C. for 30 min. The reaction mixture was partitioned between ethyl acetate and water. The aqueous was re-extracted twice with ethyl acetate and the combined organic layers washed with brine, dried over a hydrophobic frit and concentrated in vacuo to yield a brown oil. It was dissolved in DCM and passed through silica (100 g) eluting with a 10-50% ethyl acetate in cyclohexane gradient. Appropriate fractions were combined and concentrated in vacuo to yield the title compound as a yellow solid, 1.0 g. Chiral separation was achieved (Sample preparation: Sample dissolved in ethanol (30 ml) sonicating and heating with air gun as required. 4-5 ml injections were then pumped onto a preparative scale Whelk-O(S,S) column (2 inch). Details as follows: Column-Whelk-O(S,S) (50×250 mm, 10 micron); Detection-UV DAD-300 nm (bandwidth 180 nm, reference 550 nm (bandwidth 100 nm)); Flow Rate-70 ml/min; Mobile Phase A: Heptane; Mobile Phase B: IPA; Isocratic method (premixed) 5% B; Runtime-60 min; Number of runs-8) to yield the title compound (second eluting peak from the chiral column) as a yellow solid (441 mg). LCMS (Method B): Rt=1.27 min, MH+=414 The following intermediate was obtained as the first eluting peak from the chiral separation above: Intermediate 38: 1,1-dimethylethyl 3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-4,4-difluoro-1-piperidinecarboxylate (Isomer 1) LCMS (Method B): Rt=1.27 min, MH+=414

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 1379338-74-5, These common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

C) (9/-/-fluoren-9-yl)methyl 5-(7-chloropyrido[4,3-?>]pyrazi n-5- yl)hexahyd ropy rrolo[3,4-?>] pyrrole- 1 (2H)-carboxylateThe mixture of (9/-/-fluoren-9-yl)methyl hexahydropyrrolo[3,4-?>]pyrrole-1 (2/-/)- carboxylate (100 mg, 0.5 mmol) and 5,7-dichloropyrido[4,3-?>]pyrazine (600 mg, 1 .8 mmol) in dioxane was stirred at 0 C for 30 minutes and then at room temperature for 4 hours. The mixture was concentrated, and the residue was purified bychromatography to give the title compound. MS (m/z): 498 (M+H)+.

Statistics shows that 5,7-Dichloropyrido[3,4-b]pyrazine is playing an increasingly important role. we look forward to future research findings about 1379338-74-5.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; JI, Jianguo; WO2012/167733; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1379338-74-5, COA of Formula: C7H3Cl2N3

(A) /V-(3-ami nopropyl)-7-chloropyrido[4,3-ib]pyrazi n-5-ami ne.A solution of propane-1 ,3-diamine (890 mg, 12 mmol) and 5,7-dichloropyrido[4,3- ?>]pyrazine (600 mg, 3 mmol) in methanol (10 mL) was stirred at room temperature for 4 hours. The volatiles were evaporated, and the residue was purified by chromatography to afford the title compound. MS (m/z): 238 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,7-Dichloropyrido[3,4-b]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; JI, Jianguo; WO2012/167733; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1379338-74-5, Quality Control of 5,7-Dichloropyrido[3,4-b]pyrazine

1,1-dimethylethyl (3R)-3-(aminomethyl)-4-methyl-1-piperazinecarboxylate (143 mg, 0.624 mmol) and diisopropylethylamine (0.131 ml, 0.750 mmol) were added to a solution of 5,7-dichloropyrido[3,4-b]pyrazine (100 mg, 0.500 mmol) in dry N-methyl-2-pyrrolidone (NMP) (2 ml). The reaction was heated at 130 C. in the microwave for 30 min. After cooling, the reaction was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate (*2). The combined organics were washed with brine, dried using a hydrophobic frit and evaporated to give an orange oil. The residue was loaded in dichloromethane and purified on silica (25 g) using a 0-100% ethyl acetate/cyclohexane gradient. Appropriate fractions were combined and evaporated to give the title compound as yellow oil (162 mg). LCMS (Method A): Rt=1.2 min, MH+=393/395

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,7-Dichloropyrido[3,4-b]pyrazine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 1379338-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

(E) ie/t-buty. 3-((7-chioropyrido[4.3-??]pyrazi n-5-ylami no)methyl)-4- hydroxypiperidi ne-1 -carboxylate.5,7-dichloropyrido[4,3-?>]pyrazine (3.6 g, 18 mmol) and DIPEA (2.8 g, 21 .6 mmol) was added to a solution of ferf-buty. terf-buty. 3-(aminomethyi)-4-{terf~butyldimethyisiiyioxy)piperidine-1 -carboxylate (6.2 g, 18 mmol) in THF (20 mL) and the mixture was refluxed overnight. The volatile components were evaporated and the residue was extracted with ethyl acetate. Ethyl acetate was washed with brine and dried. The solvent was removed and the residue was re-dissolved in THF (16 mL) and TBAF was added in. The reaction mixture was stirred at room temperature for 2 hours. The mixture was diluted with ethyl acetate, washed with brine, then dried, filtered, and concentrated in vacuo. The crude residue was purified by flashchromatography to give the title compound (3.35 g, 47% yield). MS (m/z): 394(M+H)+.

The synthetic route of 5,7-Dichloropyrido[3,4-b]pyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; JI, Jianguo; WO2012/167423; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H3Cl2N3

(D) (S)-1 -(1 -(7-chloropyrido[4,3-ib]pyrazi n-5-yl)pyrrolidi n-3-yl)ethanol .[01 60] (S)-teri-butyl 3-(1 -hydroxyethyl)pyrrolidine-1 -carboxylate was treated with HCI solution (in EtOAc, 5 mL) at room temperature for 2 hours . The volatiles were removed under reduced pressure, and the residue was dissolved in anhydrous THF (10 mL). To the resulted THF solution, DIPEA (570 mg, 4.4 mmol) and 5,7- dichloropyrido[4,3-?>]pyrazine (400 mg, 2.0 mmol) were added, and the reaction was stirred at room temperature overnight. The volatiles were removed under reduced pressure, and the residue was dissolved in ethyl acetate, washed with brine and dried over Na2SO4, filtered, and concentrated. The residue was purified by chromatography to afford the title compound. MS (m/z): 279 (M+H)+.

The synthetic route of 1379338-74-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; JI, Jianguo; WO2012/167423; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 1379338-74-5, A common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 20: 1,1-Dimethylethyl (2S)-2-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)oxy]methyl}-4-morpholinecarboxylate 1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-4-morpholinecarboxylate (Preparation reference: WO 2009/071658) (586 mg, 2.70 mmol) was dissolved in N,N-Dimethylformamide (7 mL) and cooled in an ice bath to 5 C. under a nitrogen atmosphere. Sodium hydride 60% in mineral oil (162 mg, 4.05 mmol) was added portionwise over 15 min. 5,7-dichloropyrido[3,4-b]pyrazine (647 mg, 3.24 mmol) was then added portionwise and the mixture stirred at 5 C. for 35 min and quenched by addition of saturated aqueous ammonium chloride solution (20 mL). The solution was partitioned between ethyl acetate and water. The aqueous was re-extracted with ethyl acetate and the combined organic layers were washed with water, separated using a phase separation cartridge and the solvent removed to give a brown solid. The crude residue was dissolved in DCM and purified by silica chromatography eluting with a 12-62% ethyl acetate in petroleum ether gradient. The appropriate fractions were combined and the solvent was evaporated to give the title compound as a brown solid (917 mg). LCMS (Method B): Rt=1.12 min, MH+=380.9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXO GROUP LIMITED; Atkinson, Francis Louis; Atkinson, Stephen John; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander G.; Shipley, Tracy Jane; Wilson, David Matthew; Watson, Robert J.; US2014/5188; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H3Cl2N3

Intermediate 18: 1,1-Dimethylethyl (3S)-3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)oxy]methyl}-1-piperidinecarboxylate 1,1-Dimethylethyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate (129 mg, 0.600 mmol) (Apollo Scientific Limited) was taken up in N,N-dimethylformamide (DMF) (3 ml), treated with sodium hydride (23.99 mg, 0.600 mmol) and allowed to stir at room temperature for 20 min, a yellow solution resulted. 5,7-dichloropyrido[3,4-b]pyrazine (100 mg, 0.500 mmol) was added and the reaction was allowed to stir at room temperature for a further 1 h. The reaction was partitioned between EtOAc (50 ml) and NH4Cl (50 ml). The organic layer was dried using a hydrophobic frit and concentrated to give a brown oil. This oil was purified on silica (25 g) using a 0-40% EtOAc/cyclohexane gradient. The appropriate fractions were summed and concentrated to give the title compound as a yellow gum (91 mg). LCMS (Method B): Rt=1.26 min, MH+=378.88

The synthetic route of 5,7-Dichloropyrido[3,4-b]pyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; Atkinson, Francis Louis; Atkinson, Stephen John; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander G.; Shipley, Tracy Jane; Wilson, David Matthew; Watson, Robert J.; US2014/5188; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 1379338-74-5,Some common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of (S)-tert-butyl 3-(aminomethyl)piperidine-1-carboxylate (100 mg, 0.5 mmol), 5,7-dichloropyrido[4,3-b]pyrazine (100 mg, 0.5 mmol) and DIPEA (77 mg, 0.6 mmol) in THF (5 mL) was stirred at room temperature for 4 hours. The volatiles were removed under reduced pressure, and the residue was treated with ethyl acetate, with brine, and concentrated to give the crude title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,7-Dichloropyrido[3,4-b]pyrazine, its application will become more common.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; Su, Wei-Guo; Deng, Wei; Ji, Jianguo; US2014/121200; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 1379338-74-5,Some common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 6-(aminomethyl)morpholin-3-one (130 mg, 1 mmol), 5,7-dichloropyrido[4,3-b]pyrazine (200 mg, 1 mmol) and DIEA (260 mg, 2 mmol) in THF (20 mL) was stirred at reflux overnight. After concentration, the residue was purified by column chromatography to give product as yellow solid (100 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,7-Dichloropyrido[3,4-b]pyrazine, its application will become more common.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; Su, Wei-Guo; Deng, Wei; Ji, Jianguo; US2014/121200; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem