1379338-74-5 Archives

Sep-21 News Extended knowledge of 1379338-74-5

Statistics shows that 5,7-Dichloropyrido[3,4-b]pyrazine is playing an increasingly important role. we look forward to future research findings about 1379338-74-5.

Application of 1379338-74-5, These common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 18: 1,1-Dimethylethyl (3S)-3-{r(7-chloropyridor3,4-6lpyrazin-5- yl)oxy1methyl)-1-piperidinecarboxylate; 1 , 1-Dimethylethyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate (129mg, 0.600mmol) (Apollo Scientific Limited) was taken up in N,N-dimethylformamide (DMF) (3ml), treated with sodium hydride (23.99mg, 0.600mmol) and allowed to stir at room temperature for 20min, a yellow solution resulted. 5,7-dichloropyrido[3,4- £>]pyrazine (100mg, 0.500mmol) was added and the reaction was allowed to stir at room temperature for a further 1 h. The reaction was partitioned between EtOAc (50ml) and NH4CI (50ml). The organic layer was dried using a hydrophobic frit and concentrated to give a brown oil. This oil was purified on silica (25g) using a 0-40% EtOAc/cyclohexane gradient. The appropriate fractions were summed and concentrated to give the title compound as a yellow gum (91 mg).LCMS (Method B): Rt = 1.26min, MH+ = 378.88

Statistics shows that 5,7-Dichloropyrido[3,4-b]pyrazine is playing an increasingly important role. we look forward to future research findings about 1379338-74-5.

Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Francis Louis; ATKINSON, Stephen John; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander G; SHIPLEY, Tracy Jane; WILSON, David Matthew; WATSON, Robert J; WO2012/123312; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

S News Extracurricular laboratory: Synthetic route of 1379338-74-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 1379338-74-5, A common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The mixture of (9H-fluoren-9-yl)methyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate (100 mg, 0.5 mmol) and 5,7-dichloropyrido[4,3-b]pyrazine (600 mg, 1.8 mmol) in dioxane was stirred at 0 C. for 30 minutes and then at room temperature for 4 hours. The mixture was concentrated, and the residue was purified by chromatography to give the title compound. MS (m/z): 498 (M+H)+.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; Su, Wei-Guo; Deng, Wei; Ji, Jianguo; US2014/121200; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

6-Sep-21 News Simple exploration of 1379338-74-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,7-Dichloropyrido[3,4-b]pyrazine, its application will become more common.

Reference of 1379338-74-5,Some common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 5: 1 ,1-Dimethylethyl (3 ~)-3-fr(7-chloropyridor3,4-blpyrazin-5- yl)amino1methviyi-piperidinecarboxylate; 5,7-dichloropyrido[3,4-b]pyrazine (1g, 5.00mmol) was taken up in N-Methyl-2- pyrrolidone (NMP) (10ml) and treated with 1 , 1-dimethylethyl (3f~)-3-(aminomethyl)-1- piperidinecarboxylate (1.179g, 5.50mmol) (Apollo Scientific Ltd) and diisopropylethylamine (1.310ml, 7.50mmol). The reaction was irradiated in a Biotage microwave at 130C for 30min. The reaction was partitioned between EtOAc (100ml) and water (100ml). The organic layer was washed with brine (100ml), dried using a hydrophobic frit and concentrated to give a black solid. This solid was purified on silica (50g) and eluted with a 10-40% EtOAc/cyclohexane gradient. The appropriate fractions were combined and concentrated to give the title compound as a deep orange solid (1.542g).LCMS (Method B): Rt = 1.28min, MH+ = 377.92

September 3,2021 News New learning discoveries about 1379338-74-5

Application of 1379338-74-5,Some common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 33: 1,1-Dimethylethyl-2-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-4-morpholinecarboxylate 1,1-Dimethylethyl-2-(aminomethyl)-4-morpholinecarboxylate (60 mg, 0.28 mmol) was dissolved in N-methyl-2-pyrrolidinone (NMP) (1 mL) and to this was added DIPEA (0.07 mL, 0.38 mmol) and 5,7-dichloropyrido[3,4-b]pyrazine (50 mg, 0.25 mmol). This was heated at 130 C. for 30 min. The reaction mixtures were partitioned between ethyl acetate (50 ml) and water (50 mL) and the organic layer washed with water (50 mL), dried over a hydrophobic frit and concentrated in vacuo to yield an orange gum. It was dissolved in DCM and passed through silica (10 g) eluting with a 10-40% ethyl acetate in cyclohexane gradient. Appropriate fractions were combined and concentrated in vacuo to yield the title compound as a yellow solid, 91 mg. LCMS (Method B): Rt=1.17 min, MH+ 380

Reference:
Patent; GLAXO GROUP LIMITED; Atkinson, Francis Louis; Atkinson, Stephen John; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander G.; Shipley, Tracy Jane; Wilson, David Matthew; Watson, Robert J.; US2014/5188; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

September 2,2021 News Sources of common compounds: 1379338-74-5

The chemical industry reduces the impact on the environment during synthesis 5,7-Dichloropyrido[3,4-b]pyrazine. I believe this compound will play a more active role in future production and life.

Reference of 1379338-74-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, This compound has unique chemical properties. The synthetic route is as follows.

A solution of tert-butyl 3-(aminomethyl)-5-(tert-butyldimethylsilyloxy)piperidine-1-carboxylate (4.74 g, 13.7 mmol), 5,7-dichloropyrido[4,3-b]pyrazine (2.75 g, 13.7 mmol) and DIPEA (2.12 g, 16.4 mmol) in THF (20 mL) was stirred at room temperature for 48 hours. The volatiles were removed under reduced pressure and the residue was treated with ethyl acetate, washed with brine, dried over Na2SO4, filtered, and concentrated to give the title compound.

The chemical industry reduces the impact on the environment during synthesis 5,7-Dichloropyrido[3,4-b]pyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; Su, Wei-Guo; Deng, Wei; Ji, Jianguo; US2014/121200; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Extracurricular laboratory: Synthetic route of 1379338-74-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,7-Dichloropyrido[3,4-b]pyrazine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1379338-74-5, The chemical industry reduces the impact on the environment during synthesis 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, I believe this compound will play a more active role in future production and life.

(A) methyl 3-(7-chloropyrido[4,3-ib]pyrazi n-5-ylamino)propanoate.[01 62] A solution of methyl 3-aminopropanoate hydrochloride (4.88 mmol), Et3N (6.50 mmol) and 5,7-dichloropyrido[4,3-£>]pyrazine (3.25 mmol) in THF (10 mL) was stirred at room temperature overnight. Volatiles were removed under reduced pressure, and the residue was treated with water and extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated. The residue was purified by chromatography to afford the title compound. MS (m/z): 267 (M+H)+.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; JI, Jianguo; WO2012/167423; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Introduction of a new synthetic route about 1379338-74-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1379338-74-5, its application will become more common.

Some common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5,7-Dichloropyrido[3,4-b]pyrazine

Intermediate 29: 1,1-Dimethylethyl 3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)oxy]methyl}-4,4-difluoro-1-piperidinecarboxylate 1,1-Dimethylethyl 4,4-difluoro-3-(hydroxymethyl)-1-piperidinecarboxylate (207 mg, 0.825 mmol) was dissolved in dry N,N-dimethylformamide (DMF) (5 ml) and sodium hydride (45.0 mg, 1.125 mmol) was added under nitrogen at room temperature. After 60 min, 5,7-dichloropyrido[3,4-b]pyrazine (150 mg, 0.750 mmol) was added and the reaction was stirred at room temperature under nitrogen for 2 h. The reaction was quenched by the addition of sat. ammonium chloride solution and extracted with ethyl acetate. The aqueous layer was extracted further with ethyl acetate. The combined organics were washed with water, dried using a hydrophobic frit and evaporated in vacuo to give an orange oil (369 mg). The residue was loaded in dichloromethane and purified on silica (50 g) column using a 0-100% ethyl acetate/cyclohexane gradient. Appropriate fractions were combined and evaporated to give the title compound as an orange oil (163 mg). LCMS (Method B): Rt=1.25 min, MH+=415

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1379338-74-5, its application will become more common.

The important role of C7H3Cl2N3

The synthetic route of 1379338-74-5 has been constantly updated, and we look forward to future research findings.

Intermediate 22: 1 ,1-Dimethylethyl (2/~)-2-{r(7-chloropyridor3,4-6lpyrazin-5- yl)amino1methylV4-morpholinecarboxylate; 1 , 1-dimethylethyl (2f~)-2-(aminomethyl)-4-morpholinecarboxylate (for preparation see: J. Medicinal Chemistry, 2009, 52 (15), 4810-4819) (6g, 27.7mmol) was dissolved in N-methyl-2-pyrrolidinone (NMP) (60ml_) and to this was added DIPEA (7.27ml_, 41.6mmol) and 5,7-dichloropyrido[3,4-b]pyrazine (5.55g, 27.7mmol). This was split between 4 large microwave vials and each was heated at 130C for 30min. They were monitored by LCMS and were given a further 10min at 130C. The reaction mixtures were partitioned between ethyl acetate (700ml) and diluted aqueous ammonium chloride (1 litre). The aqueous was reextracted with ethyl acetate (300ml) and the combined organics were washed with aqueous ammonium chloride (500ml), dried over sodium sulfate and concentrated in vacuo to yield a crude brown oil. It was dissolved in DCM and passed through silica (70g) eluting with DCM (6 X 40ml) then 5% ethyl acetate in DCM (2 X 40ml), 10% ethyl acetate in DCM (5 X 40ml) then 15% ethyl acetate in DCM (2 X 40ml) then 20%ethyl acetate in DCM (2 X 40ml). Appropriate fractions were combined and concentrated in vacuo to yield: N8231-100-2, orange-yellow slightly gummy solid, 7.7gLCMS (Method B): Rt = 1.17min, MH+ 380

The synthetic route of 1379338-74-5 has been constantly updated, and we look forward to future research findings.

Analyzing the synthesis route of 1379338-74-5

The synthetic route of 1379338-74-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5,7-Dichloropyrido[3,4-b]pyrazine

Intermediate 20: 1 ,1-Dimethylethyl (2S)-2-{r(7-chloropyridor3,4-6lpyrazin-5- yl)oxy1methyl)-4-morpholinecarboxylate; 1 , 1-Dimethylethyl (2S)-2-(hydroxymethyl)-4-morpholinecarboxylate (Preparation reference: WO 2009/071658) (586mg, 2.70mmol) was dissolved in N,N- Dimethylformamide (7ml_) and cooled in an ice bath to 5C under a nitrogen atmosphere. Sodium hydride 60% in mineral oil (162mg, 4.05mmol) was added portionwise over 15min. 5,7-dichloropyrido[3,4-b]pyrazine (647mg, 3.24mmol) was then added portionwise and the mixture stirred at 5C for 35min and quenched by addition of saturated aqueous ammonium chloride solution (20ml_). The solution was partitioned between ethyl acetate and water. The aqueous was re-extracted with ethyl acetate and the combined organic layers were washed with water, separated using a phase separation cartridge and the solvent removed to give a brown solid. The crude residue was dissolved in DCM and purified by silica chromatography eluting with a 12-62% ethyl acetate in petroleum ether gradient. The appropriate fractions were combined and the solvent was evaporated to give the title compound as a brown solid (917mg).LCMS (Method B): Rt = 1.12min, MH+ = 380.9

The synthetic route of 1379338-74-5 has been constantly updated, and we look forward to future research findings.

Simple exploration of 1379338-74-5

Reference of 1379338-74-5, The chemical industry reduces the impact on the environment during synthesis 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, I believe this compound will play a more active role in future production and life.

Intermediate 22: 1,1-Dimethylethyl (2R)-2-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-4-morpholinecarboxylate 1,1-dimethylethyl (2R)-2-(aminomethyl)-4-morpholinecarboxylate (for preparation see: J. Medicinal Chemistry, 2009, 52 (15), 4810-4819) (6 g, 27.7 mmol) was dissolved in N-methyl-2-pyrrolidinone (NMP) (60 mL) and to this was added DIPEA (7.27 mL, 41.6 mmol) and 5,7-dichloropyrido[3,4-b]pyrazine (5.55 g, 27.7 mmol). This was split between 4 large microwave vials and each was heated at 130 C. for 30 min. They were monitored by LCMS and were given a further 10 min at 130 C. The reaction mixtures were partitioned between ethyl acetate (700 ml) and diluted aqueous ammonium chloride (1 litre). The aqueous was reextracted with ethyl acetate (300 ml) and the combined organics were washed with aqueous ammonium chloride (500 ml), dried over sodium sulfate and concentrated in vacuo to yield a crude brown oil. It was dissolved in DCM and passed through silica (70 g) eluting with DCM (6*40 ml) then 5% ethyl acetate in DCM (2*40 ml), 10% ethyl acetate in DCM (5*40 ml) then 15% ethyl acetate in DCM (2*40 ml) then 20% ethyl acetate in DCM (2*40 ml). Appropriate fractions were combined and concentrated in vacuo to yield: N8231-100-2, orange-yellow slightly gummy solid, 7.7 g LCMS (Method B): Rt=1.17 min, MH+ 380