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Brief introduction of 136927-64-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloropyrrolo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Related Products of 136927-64-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

PREPARATION 21 1-benzyloxypyrrolo[1,2-a]pyrazine (A compound of formula (DD)) To a solution of sodium hydride in anhydrous dimethylformamide was added benzyl alcohol (0.64 g, 5.9 mmol). The reaction mixture was stirred for 15 minutes. 1-chloropyrrolo[1,2-a]pyrazine (0.90 g, 5.9 mmol) in anhydrous dimethylformamide was then rapidly added to the reaction mixture. The reaction mixture was then heated to 100 C. for approximately 30 minutes. It was then allowed to cool to room temperature and water was added. The product was then extracted with methylene chloride, washed with a saturated sodium chloride solution, dried over MgSO4 and evaporated. The product was then purified by recrystallization in ether-hexane to give the title compound,

Reference:
Patent; Syntex (U.S.A.) Inc.; US5041442; (1991); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A new synthetic route of 136927-64-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 136927-64-5, its application will become more common.

Some common heterocyclic compound, 136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Chloropyrrolo[1,2-a]pyrazine

To a solution of (5)-tert-butyl pyrrolidin-3-ylcarbamate (0.91 g, 4.9 mmol, 1 eq) in 2.6 mL of DIPEA was added 1-chloropyrrolo[1,2-a]pyrazine (0.75 g, 4.9 mmol, 1 eq) and 1 drop of 1-butyl-3-methylimidazolium tetrafluorborate. After heating for 3 h at 110 C., the mixture was concentrated and purified by silica gel flash chromatography (100% EtOAc) to afford (S)-tert-butyl N-(1-(pyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl)carbamate (0.88 g, 2.9 mmol, 59%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 136927-64-5, its application will become more common.

Reference:
Patent; ChemoCentryx, Inc.; Fan, Junfa; Krasinski, Antoni; Lange, Christopher W.; Lui, Rebecca M.; McMahon, Jeffrey P.; Powers, Jay P.; Zeng, Yibin; Zhang, Penglie; US2014/154179; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Analyzing the synthesis route of 136927-64-5

The synthetic route of 136927-64-5 has been constantly updated, and we look forward to future research findings.

136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H5ClN2

To a stirred solution of 1-chloro-pyrrolo[1 ,2-a]pyrazine (1.53g, 10 mmol) in THF (90 ml.) was added at 0 C a solution of 1 ,3-dibromo-5,5-dimethylhydantoin (1.49g, 4.9mmol) in THF (10 ml_), via dropping funnel. The funnel was washed with a little THF and this added to the reaction mixture. The reaction mixture was stirred for an hour at 0 C, diluted with DCM and washed with saturated sodium bicarbonate solution. The aqueous layer was back-extracted with DCM. The organic extracts were passed through a hydrophobic frit and evaporated. The residue was purified on silica eluting with 8% EtOAc in iso- hexane to give the title compound as a white solid (1.54 g, 67 %). (0617) [00321] 1 H NMR (CDCI3 ppm) d 7.8 (dd, 1 H, J = 5, 1 Hz), 7.5 (d, 1 H J = 5 Hz ), 7.0 (0618) (dd, 1 H, J = 4, 1 Hz), 6.9 (d 1 H, J = 4Hz). LCMS (m/z) [M+H] 231 , 233

The synthetic route of 136927-64-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH; WALKINSHAW, Malcolm D.; PETTIT, Simon Neil; HIGHTON, Adrian; MCNAE, Iain William; (117 pag.)WO2019/106368; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Extracurricular laboratory: Synthetic route of 136927-64-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 136927-64-5

To a mixture of 1 (120 mg, 0.59 mmol) and 2 (90 mg, 0.59 mmol) was added 1.0 ml of Hunig?s base (5.5mmol). The resulting mixture was stirred at 130 C. for 3 h. After the mixture was cooled down to room temperature, 200ml of isopropanol/chloroform (1:2) was added, and the organics were washed with saturated aqueous NaHC03 (2×20 ml)and brine (2×50 ml). The organics were dried over MgSO4 and concentrated under reduced pressure. The residue was purified via flash column chromatography on silica gel (0-10% MeOH in EtOAc) to get the desired product 3 as a brown powder (150 mg, 79%).

Research on new synthetic routes about 136927-64-5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 136927-64-5, Computed Properties of C7H5ClN2

Compound C4 (63.0 mg, 0.294 mmol), 1-chloropyrrolo[1,2-a]pyrazine (32.5 mg,0.21 mmol), and cesium carbonate (208 mg, 0.64 mmol) were combined in dimethylsulfoxide (1.0 mL), and the mixture was degassed with nitrogen for 5 minutes. After the reaction mixture had been heated to 120 C for 72 hours, it was cooled to room temperature, diluted with ethyl acetate, and filtered through diatomaceous earth. The filter pad was rinsed with ethyl acetate, and the combined filtrates were washed with 1:1water I saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered,and concentrated in vacuo. Purification using silica gel chromatography (Gradient: 0%to 5% methanol in dichloromethane) afforded the product as a white solid. Yield: 34 mg,0.10 mmol, 48%. LCMS m/z 331.1 [M+H]. 1H NMR (400 MHz, CDCI3) oe 9.00 (5, 1H),7.62 (d, J=4.8 Hz, 1H), 7.47-7.45 (m, 1H), 7.28-7.22 (m, 2H), 7.11-7.09 (m, 2H), 6.99-6.98 (m, 1H), 6.86-6.85 (m, 1H), 2.29 (5, 6H), 2.05 (5, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; PFIZER INC.; GRAY, David Lawrence Firman; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; MENTE, Scot Richard; SUBRAMANYAM, Chakrapani; WO2015/166370; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The important role of 136927-64-5

The chemical industry reduces the impact on the environment during synthesis 1-Chloropyrrolo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.

To a solution of the crude amine in 0.16 mL of diisopropylethylamine was added 1-chloropyrrolo[1,2-a]pyrazine (0.047 g, 0.31 mmol) followed by 1 drop of 1-butyl-3-methylimidazolium tetrafluorborate. The reaction was heated at 90 C. for 20 h. Purification of the residue by HPLC afforded (S)-6-chloro-N-(1-(pyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl)quinazoline-2-carboxamide (0.05 g, 0.013 mmol, 6%). 1H NMR (400 MHz, CD3OD) delta 9.60 (s, 1H), 8.26 (s, 1H), 8.17 (d, J=9.1 Hz, 1H), 8.07 (dd, J=1.8, 9.1 Hz, 1H), 7.76 (d, J=1.5 Hz, 1H), 7.72 (d, J=5.8 Hz, 1H), 7.57 (s, 1H), 6.93 (m, 1H), 6.85 (d, J=5.8 Hz, 1H), 5.06-4.84 (m, 1H), 4.82-3.60 (br, 4H), 2.65-2.40 (br, 2H); MS: (ES) m/z calculated for C20H17ClN6O [M+H]+393.2. found 393.

The chemical industry reduces the impact on the environment during synthesis 1-Chloropyrrolo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.