Adding a certain compound to certain chemical reactions, such as: 13457-28-8, name is Methyl 3-bromo-6-chloropyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13457-28-8, Quality Control of Methyl 3-bromo-6-chloropyrazine-2-carboxylate
To a 250 ml three-neck flask was added 50 ml of tetrahydrofuran, 50 ml of water, and Compound 3 (20 g, 0.08 mol). Lithium hydroxide monohydrate (5 g, 0.12 mol) in water/70 ml of water was added dropwise. The reaction was completed at 0C for 1 hour. The reaction is complete. Methyl tert-butyl ether extraction (30 ml x 2). The aqueous phase was adjusted to pH=1 with 4N hydrochloric acid and extracted with dichloromethane (50 ml¡Á3). Dry 10 g of anhydrous sodium sulfate and spin-dry to obtain white solid compound 4 (18 g, yield 96%).
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Reference:
Patent; Shaoyuan Science And Technology (Shanghai) Co., Ltd.; Shanghai Shaoyuan Reagent Co., Ltd.; Wei Yuanbo; Guo Tao; Wu Yong; (8 pag.)CN108101857; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem