Category: 1320266-90-7

Related Products of 1320266-90-7, The chemical industry reduces the impact on the environment during synthesis 1320266-90-7, name is 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, I believe this compound will play a more active role in future production and life.

To a solution of Intermediate 5-c (1.9 g, 9.7 mmol) in DMF cooled to 0C was slowly added a 0.7N solution of N-bromosuccinimide in DMF (15.2 ml, 10.7 mmol) under an atmosphere of nitrogen. After the addition was completed the reaction mixture was stirred for 15 minutes. Water was added; a precipitate formed, and was collected by filtration to provide Intermediate 5-e as a beige solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHARMASCIENCE INC.; LAURENT, Alain; ROSE, Yannick; WO2015/74138; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1320266-90-7, name is 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1320266-90-7

To a solution of 8-chloro-3-isopropylimidazo[1,5-ajpyrazine 3A (1.00 g, 5.11 mmol) in THFat -65 C was added dropwise a solution of n-butyllithium (2.5 M solution in THF, 2.9 mL,7.16 mmol), keeping the temperature below -55 C. The resulting dark brown solution was stirred at -78 C for 1 h then ethyl formate (0.62 mL, 7.67 mmol) was added dropwise and the mixture was stirred at -78 C for 1.5 h. The mixture was diluted with water and extracted with EtOAc. The combined organic extracts were dried (MgSO4), filtered and concentrated invacuo. The residue was purified by silica-gel chromatography, eluting with 0-50% EtOAc in isohexane to give the title compound 3B as a yellow oil that crystallised on standing (900 mg, 79%). LC-MS (Method 1): Rt = 1.06 mm, m/z = 224.1 [M(35C1)+Hf?.

According to the analysis of related databases, 1320266-90-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; OPTIKIRA LLC; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; KEENAN, Richard M.; BACKES, Bradley J.; MALY, Dustin J.; REYNOLDS, Charles; WHITTAKER, Ben; KNIGHT, Jamie; SUTTON, Jon; HYND, George; PAPA, Feroz, R.; OAKES, Scott, A.; (147 pag.)WO2019/46711; (2019); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 1320266-90-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1320266-90-7, name is 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Intermediate J (33 mg, 0.17 mmol) dissolved in 0.18 mL of DMF was added to NIS (39 mg, 0.17 mmol) dissolved in 0.6 mL of DMF. The reaction mixture was heated to 60 C for 3 h and then cooled to room temperature. The reaction mixture was partitioned between 1 M a2S03 and dichloromethane. The aqueous layer was then extracted with dichloromethane (3X). The organic layers were combined, dried over a2S04 and concentrated in vacuo to afford 34 mg (62% yield) of pure Intermediate K. .H-NMR (300 MHz, CDC13) delta 1.41 (d, 6H, / = 6.9 Hz), 3.20-3.31 (m, 1H), 7.28 (d, 1H, J= 5.1 Hz), 7.65 (d, 1H, J = 5.1 Hz). MS (ESI) (M+H)+ 322.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF WASHINGTON; VAN VOORHIS, Wesley, C.; HOL, Wilhelmus, G.J.; LARSON, Eric, T.; MALY, Dustin, James; MERRITT, Ethan; OJO, Kayode, K.; WO2011/94628; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 1320266-90-7,Some common heterocyclic compound, 1320266-90-7, name is 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, molecular formula is C9H10ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 8-chloro-3-isopropylimidazo[i,5-ajpyrazine (31 g, 158.5 mmol) indry THF (300 mL) at -78 C under nitrogen was added n-butyllithium (2.5 M in hexanes,82.4 mL, 206 mmol), keeping the internal temperature below -65 C. After stirring for 30 mma solution of iodine (56.3 g, 221.8 mmol) in THF (50 mL) was added dropwise over 10 mmkeeping the internal temperature below -65 C during addition. The resulting suspension wasstirred for 1 hour whilst warming to -10 C then the reaction mixture was quenched by theaddition of saturated aqueous NH4C1 and extracted with 2-methyltetrahydrofuran (x3). The combined organic extracts were washed with water and brine, dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by passage through a silica-gel pad, eluting with 0-20% EtOAc in DCM to give an orange solid, which was triturated with Et20 to givethe title compound 5B as a yellow solid (41.2 g, 81%). LC-MS: Rt = 1.29 mm, m/z = 322.0[M+Hj +

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, its application will become more common.

Reference:
Patent; OPTIKIRA LLC; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; KEENAN, Richard M.; BACKES, Bradley J.; MALY, Dustin J.; REYNOLDS, Charles; WHITTAKER, Ben; KNIGHT, Jamie; SUTTON, Jon; HYND, George; PAPA, Feroz, R.; OAKES, Scott, A.; (147 pag.)WO2019/46711; (2019); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 1320266-90-7, The chemical industry reduces the impact on the environment during synthesis 1320266-90-7, name is 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, I believe this compound will play a more active role in future production and life.

To a solution of Intermediate 5-c (1.9 g, 9.7 mmol) in DMF cooled to 0C was slowly added a 0.7N solution of N-bromosuccinimide in DMF (15.2 ml, 10.7 mmol) under an atmosphere of nitrogen. After the addition was completed the reaction mixture was stirred for 15 minutes. Water was added; a precipitate formed, and was collected by filtration to provide Intermediate 5-e as a beige solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHARMASCIENCE INC.; LAURENT, Alain; ROSE, Yannick; WO2015/74138; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 1320266-90-7, name is 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1320266-90-7, category: Pyrazines

Intermediate J (33 mg, 0.17 mmol) dissolved in 0.18 mL of DMF was added to NIS (39 mg, 0.17 mmol) dissolved in 0.6 mL of DMF. The reaction mixture was heated to 60 C for 3 h and then cooled to room temperature. The reaction mixture was partitioned between 1 M a2S03 and dichloromethane. The aqueous layer was then extracted with dichloromethane (3X). The organic layers were combined, dried over a2S04 and concentrated in vacuo to afford 34 mg (62% yield) of pure Intermediate K. .H-NMR (300 MHz, CDC13) delta 1.41 (d, 6H, / = 6.9 Hz), 3.20-3.31 (m, 1H), 7.28 (d, 1H, J= 5.1 Hz), 7.65 (d, 1H, J = 5.1 Hz). MS (ESI) (M+H)+ 322.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; UNIVERSITY OF WASHINGTON; VAN VOORHIS, Wesley, C.; HOL, Wilhelmus, G.J.; LARSON, Eric, T.; MALY, Dustin, James; MERRITT, Ethan; OJO, Kayode, K.; WO2011/94628; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem