Category: 1314920-48-3

Straightforward Synthesis of Functionalized 4,5,6,7-Tetrahydro-pyrazolo[1,5-a]pyrazines-Important Building Blocks for Medicinal Chemistry was written by Bozhanov, Vladimir I.;Bohdan, Dmytro P.;Borysov, Oleksandr V.;Silin, Aleksey V.;Zaremba, Oleg V.;Avramenko, Mykola M.;Volochnyuk, Dmitriy M.;Ryabukhin, Sergey V.;Gavrilenko, Konstantin S.. And the article was included in ChemistrySelect in 2022.Reference of 1314920-48-3 The following contents are mentioned in the article:

A set of building blocks based on the 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine e.g., I scaffold is synthesized in a multigram scale in a cost-efficient manner. The possibility of the introduction of different substituents, neutral or functionalized in different positions of pyrazole and/or piperazine rings, is shown. The efficacy of using NH-pyrazole carbonic acids as a key intermediate of the process is demonstrated. The regioselectivity for direct insertion of the substituent to the 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine core is discussed. The synthetic perspectives for using the functionalized 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine as a bifunctional scaffold is discussed. The utilizing of building blocks obtained for the different region- and/or stereoselective synthesis, including sole transformations or modifications of functional groups, is demonstrated. The advantages of the proposed approach are proven compared with the other known methodologies. This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3Reference of 1314920-48-3).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 1314920-48-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Facile one-pot synthesis of the pyrazolo[1,5-a]pyrazine scaffold was written by Zaremba, O. V.;Gorobets, N. Yu.;Kovalenko, S. S.;Drushlyak, O. G.;Grevtsov, O. Yu.;Kovalenko, S. M.. And the article was included in Chemistry of Heterocyclic Compounds in 2013.Category: pyrazines The following contents are mentioned in the article:

A series of novel pyrazolo[1,5-a]pyrazine derivatives I was synthesized using a facile one-pot three-step protocol starting from pyrazole-3-carboxylic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[1,5-a]-pyrazin-4(5H)-one and 7-methoxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one were isolated as intermediate compounds This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3Category: pyrazines).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Category: pyrazines

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki-Miyaura cross coupling was written by Hrynyshyn, Yevhenii V.;Musiychuk, Anna R.;Tsizorik, Nazar M.;Bol’but, Andriy V.;Vovk, Mikhailo V.. And the article was included in Chemistry of Heterocyclic Compounds in 2019.Product Details of 1314920-48-3 The following contents are mentioned in the article:

Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by the Suzuki-Miyaura cross coupling reaction of 4-bromopyrazolo[1,5-a]pyrazines with aryl(hetaryl)boronic acids in the presence of catalytic amounts of Pd(dppf)Cl₂·CH₂Cl₂ and an excess of Cs₂CO₃ in the MeCN-H₂O, 9:1 solvent system is discussed. This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3Product Details of 1314920-48-3).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Product Details of 1314920-48-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis of 8H-pyrazolo[5′,1′:3,4]pyrazino[2,1-b]quinazolin-8-ones was written by Hrynyshyn, Yevhenii V.;Tsizorik, Nazar M.;Musiychuk, Anna R.;Bol’but, Andriy V.;Vovk, Mykhailo V.. And the article was included in Chemistry of Heterocyclic Compounds in 2017.COA of Formula: C7H7N3O The following contents are mentioned in the article:

4-Chloropyrazolo[1,5-a]pyrazines reacted with anthranilic acids forming 8H-pyrazolo[5′,1′:3,4]pyrazino[2,1-b]quinazolin-8-ones I (R¹ = H, CF₃, Me, NO₂; R² = H, OMe; R³ = H, Me, OMe) representing a new heterocyclic system. This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3COA of Formula: C7H7N3O).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.COA of Formula: C7H7N3O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem