Category: 13134-31-1

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13134-31-1, name is 2,3-Diaminopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Product Details of 13134-31-1

EXAMPLE 2 2-(2-Methoxy-4-benzyloxy-phenyl)-imidazo[4,5-b]pyrazine A mixture of 2.2 g of 2,3-diaminopyrazine and 5.16 g of 2-methoxy-4-benzyloxy-benzoic acid was finely triturated in a mortar and then suspended in 80 ml of phosphorus oxychloride. The suspension was refluxed for 1.5 hours while stirring. After cooling, the reaction mixture was mixed with ice water. The solution thus obtained was neutralized with ammonia and extracted with ethyl acetate. The ethyl acetate phases were evaporated, and the residue was triturated with acetone, whereupon the reaction product was left behind in pure form. A second fraction was obtained by evaporating the acetone phase and purifying the residue on silica gel (eluant: methylene chloride/ethanol =100:0 to 100:4). Yield: 3.2 g (48% of theory). M.p. 178-180 C.

The synthetic route of 13134-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dr. Karl Thomae GmbH; US4656171; (1987); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 13134-31-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13134-31-1, name is 2,3-Diaminopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 7 2-(2-Methoxy-4-methanesulfonylamino-phenyl)-imidazo[4,5-b]-pyrazine This compound was prepared analogous to Example 2 from 2,3-diamino-pyrazine and 2-methoxy-4-methanesulfonylaminobenzoic acid. M.p. 263-265 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Diaminopyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dr. Karl Thomae GmbH; US4656171; (1987); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 13134-31-1, These common heterocyclic compound, 13134-31-1, name is 2,3-Diaminopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2,3-diaminopyrazine (55mg, 0.5mmol) and methyl 1-({5-chloro-2-[(2- methylpropyl)oxy]phenyl}methyl)-5-methyl-1/-/-pyrazole-3-carboximidoate hydrochloride (186mg, O.deltammol) in ethanol (4ml) was stirred and refluxed for 4 hours. The solid which separated was filtered, dissolved in hot methanol and 1 M hydrogen chloride in ether (0.5ml) added. The solution was evaporated to dryness and the residue triturated with ether to give the title compound as an off-white solid (17mg). LC/MS Rt 3.10, [MH]+ 397.2, 399.2

The synthetic route of 13134-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/114313; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 13134-31-1,Some common heterocyclic compound, 13134-31-1, name is 2,3-Diaminopyrazine, molecular formula is C4H6N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a) 2-(2,4-Dimethoxy-5-chlorosulfonyl-phenyl)-imidazo-[4,5-b]-pyrazine was prepared analogous to Example 2 from 2,3-diaminopyrazine and 2,4-dimethoxy-5-chlorosulfonyl-benzoylchloride. M.p. 294-296 C.

The synthetic route of 13134-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dr. Karl Thomae GmbH; US4656171; (1987); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem