Category: 127406-08-0

Adding a certain compound to certain chemical reactions, such as: 127406-08-0, name is 4-(Pyrazin-2-yl)benzaldehyde, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127406-08-0, Computed Properties of C11H8N2O

General procedure: A mixture of HPLC-purified aminooxy-His containing peptide (30 mM in DMSO, 10 muL), aldehyde (30 mM in DMSO, 10 muL) and acetic acid (150 mM in DMSO, 10 muL) was agitated at room temperature (overnight). Crude reaction mixtures were used directly for Plk1 PBD binding ELISA assays. Structures of oxime-containing peptides are shown in Table S1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Pyrazin-2-yl)benzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhao, Xue Zhi; Hymel, David; Burke, Terrence R.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 20; (2016); p. 5009 – 5012;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 127406-08-0,Some common heterocyclic compound, 127406-08-0, name is 4-(Pyrazin-2-yl)benzaldehyde, molecular formula is C11H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound from step A (6.2 g, 33.5 mmole), (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (22.6 g, 52.7 mmole), tris[2-(2-methoxyethoxy)ethyl]amine (11.2 ml, 34.9 mmole), sat. aq. K2CO3 (150 mls), and CH2Cl2 (150 ml) were heated at reflux for 17 hours. The mixture was cooled and the aqueous layer was washed with CH2Cl2 (2×). The combined organic layers were washed with NaHCO3, brine, dried (MgSO4), and concentrated.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Pyrazin-2-yl)benzaldehyde, its application will become more common.