Category: 1260812-97-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1260812-97-2, name is 2-Bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 1260812-97-2

0 C,N-iodosuccinimide (2.60 g, 11.00 mmol)Bromo-3-methyl-5H-pyrrolo [2,3-b] pyrazine (2.05 g, 7.25 mmol)In acetone (30 mL)The reaction was stirred at room temperature for 3 h.The solvent was removed under reduced pressure, water (30 mL) and dichloromethane (30 mL) were added to the residue, the solid was filtered, the solid was washed with a little water and dichloromethane,The brown solid was dried in vacuo at 60 C to give 2.50 g of a brown solid,The crude product was used without further purification for the next step.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Huang Jiuzhong; Zheng Changchun; Zhang Yingjun; Ouyang Luo; Mao Hongfen; Nie Biao; Xu Juan; Chen Hongfen; (137 pag.)CN106336413; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 1260812-97-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1260812-97-2, name is 2-Bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To anydrous ethanol (60 mL) were added2-bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine (6.00 g, 28 mmol), ammonium formate (27.00 g,428 mmol) and 10% Pd/C (6 g). The mixture was refluxed for 5 hours under nitrogen protection.The reaction mixture was filtered through a celite pad, concentrated in vacuo to remove thesolvent, and the residue was purified by silica gel column chromatography (PE/EA (v/v) =411-211) to give the title compound as a yellow solid (3.10 g, 82 %).MS (ESI, pos. ion) m/z: 134.2 [M+Ht.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (303 pag.)WO2018/108125; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem