Category: 1250996-70-3

Reference of 1250996-70-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1250996-70-3, name is tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

[0083] Method A-Step d: Preparation of (5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin2- yl)methanol [0084] Tert-butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxylate (200 mg, 0.79 mmol) was dissolved in 3M HCl/ethyl acetate (3 mL). The mixture was stirred at room temperature for 4 hours, then the solvent was removed under vacuum. The residue was applied to silica gel column chromatography (CH2Cl2:MeOH:NH3-H20 = 100:10: 1) to give a yellow oil (100 mg, 82.6%). *H NMR (400 MHz, CDC13) delta 6.77 (s, 1H), 4.57 (s, 2H), 4.09 (s, 2H), 3.94 (t, J = 5.4 Hz, 2H), 3.24 (t, J = 5.2 Hz, 2H).

The synthetic route of tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

1250996-70-3, name is tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

To a solution of 2-hydroxymethyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester (IV, 0.34 g, 1.34 mmol) in dry methanol (12 mL) was added 20% HQ in dioxane (18 mL) at 0 C and the resulting mixture was stirred at room temperature for 16 h. The solvent was evaporated under reduced pressure to get the crude product which was triturated with diethylether to afford the titled product as a pale-yellow solid (V, 0.25 g, 95 %). LC-MS m/z calcd for C7HuN30, 153.1 ; found 154.2 [M+H]+.

The synthetic route of 1250996-70-3 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1250996-70-3, name is tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C12H19N3O3

[0090] Method B-Step g: Preparation of tert-butyl 2-(morpholinomethyl)-5,6- dihydroimidazo[l,2-a]pyrazine-7(8H)-carboxylate [0091] To a solution of tert-butyl 2-(hydroxymethyl)-5,6-dihydro imidazo[l,2-a]pyrazine- 7(8H)-carboxylate (400 mg, 1.579 mmol) and triethylamine (320 mg, 3.158 mmol) in CH2C12 (4 mL) was added methanesulfonyl chloride (199 mg, 1.737 mmol) dropwise at 0 C. The mixture was stirred at room temperature for 30 minutes. TLC showed the reaction was complete. The reaction mixture was poured into 10 mL of ethyl acetate and washed with water (3 mL) twice. The organic layer was dried over Na2S04 and concentrated in vacuo, then dissolved in DMF (8 mL) with K2CC>3 (395 mg, 3.98 mmol), then morpholine (347 mg, 3.98 mmol) was added. The mixture was stirred at 100 C for 2 hours. TLC showed that the reaction was complete. The reaction mixture was portioned between ethyl acetate (20 mL) and water (5 mL), washed with brine (5 mLx3). The organic layer was concentrated under reduced pressure, purified by silica gel column chromatography (CH2Cl2:MeOH = 50:1 ) to give a brown oil (220 mg, 51.43%). *H NMR (400 MHz, CDC13) delta 6.75 (s, 1H), 4.67 (s, 2H), 3.94 (d, / = 2.6 Hz, 2H), 3.83 (s, 2H), 3.74 (m, 7=4.4 Hz, 4H), 3.45 (s, 2H), 2.53 (s, 4H), 1.48 (s, 9H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1250996-70-3.