1245644-42-1 Archives

9/26/2021 News Extracurricular laboratory: Synthetic route of 1245644-42-1

The synthetic route of 1245644-42-1 has been constantly updated, and we look forward to future research findings.

Related Products of 1245644-42-1, These common heterocyclic compound, 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 6-bromo-3-iodoimidazo[l ,2-a]pyrazine (3 g, 9.26 mmol) in DMF (50 mL), were added 4-cyanophenylboronic acid 3 (1.632 g, 11.1 mmol), K3P04 (4.91 g, 23.15 mmol), Pd(PPh3)4 (0.534 mg, 0.46 mmol) and water (5 mL). The reaction mixture was heated at 90 C for 1 h and water was added to the mixture to induce precipitation. The precipitate was isolated by filtration and was purified by column chromatography (silica gel, eluent petroleum ether/EtOAc 1 :1) to afford of 4-(6-bromoimidazo[l,2-a]pyrazin-3-yl)benzonitrile (2.5 g, 90%) as an off-white solid. 1H NMR (400 MHz, DMSO-< delta 9.88 (s, 1H), 8.90 (s, 1H), 8.27 (s, 1H), 8.05-7.99 (m, 4H); MS (ESI) m/z 301.1 [C13H7BrN4+2 ]+. The synthetic route of 1245644-42-1 has been constantly updated, and we look forward to future research findings. Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 1245644-42-1

The synthetic route of 1245644-42-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1245644-42-1, A common heterocyclic compound, 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, molecular formula is C6H3BrIN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 : To a solution of 6-bromo-3-iodoimidazo[l ,2-a]pyrazine (3.00 g, 9.26 mmol) in DMF (20 mL), was added Na2C03 (2.46 g, 23.2 mmol), 4-chlorophenylboronic acid (1.60 g, 10.2 mmol) and Pd(PPh3)4 (214 mg, 0.18 mmol). The resulting mixture was stirred at 80 C for 18 h under inert atmosphere and was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluent Hex/EtOAc 3:2) to afford 6-bromo-3- (4-chlorophenyl)imidazo[l,2-a]pyrazine (930 mg, 32%) as a yellow solid. 1H NMR (400 MHz, CDC13) delta 9.03 (d, J= 1.2 Hz, 1H), 8.36 (d, J= 1.2 Hz, 1H), 7.91 (s, 1H), 7.54 (q, J =12.3 Hz, 4H); MS (ESI) m/z 308 [C13H7BrN4 + H]+.

The synthetic route of 1245644-42-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Analyzing the synthesis route of 1245644-42-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1245644-42-1, its application will become more common.

Some common heterocyclic compound, 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, molecular formula is C6H3BrIN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6-Bromo-3-iodoimidazo[1,2-a]pyrazine

General procedure: 6-Bromo-3-thiophen-2-yl-imidazo[1,2- a]pyrazine 18*c Note: An additional 1 mol% of Palladium Acetate and triphenylphosphine was added after 12 hours to increase the yield of the reaction. 1H-NMR (400 MHz, CDCl3): delta = 8.94 (s, 1 H), 8.49 (s, 1 H), 7.95 (s, 1 H), 7.55 (d, J =5.2Hz, 1 H), 7.38 (d, J =3.2Hz, 1 H), 7.27 (s, 1H). Yield: 42.3%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1245644-42-1, its application will become more common.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel; Falcenberg, Mathias; EP2818471; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Continuously updated synthesis method about 1245644-42-1

According to the analysis of related databases, 1245644-42-1, the application of this compound in the production field has become more and more popular.

Synthetic Route of 1245644-42-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1245644-42-1 as follows.

To a solution of 6-bromo-3-iodoimidazo[1,2-a]pyrazine (3.00 g, 9.26 mmol) in DMF (20 mL), was added Na2CO3 (2.46 g, 23.2 mmol), 4-chlorophenylboronic acid (1.60 g, 10.2 mmol) and Pd(PPh3)4 (214 mg, 0.18 mmol). The resulting mixture was stirred at 80 C. for 18 h under inert atmosphere and was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluent Hex/EtOAc 3:2) to afford 6-bromo-3-(4-chlorophenyl)imidazo[1,2-a]pyrazine (930 mg, 32%) as a yellow solid. 1H NMR (400 MHz, CDCl3) delta 9.03 (d, J=1.2 Hz, 1H), 8.36 (d, J=1.2 Hz, 1H), 7.91 (s, 1H), 7.54 (q, J=12.3 Hz, 4H); MS (ESI) m/z 308 [C13H7BrN4+H]+.

According to the analysis of related databases, 1245644-42-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Agency for Science, Technology and Research; Nacro, Kassoum; Duraiswamy, Athisayamani Jeyaraj; Rao, Lohitha; US2014/371199; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Simple exploration of 1245644-42-1

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines

To a solution of 6-bromo-3-iodoimidazo[1,2-a]pyrazine (3 g, 9.26 mmol) in DMF (50 mL), were added 4-cyanophenylboronic acid 3 (1.632 g, 11.1 mmol), K3PO4 (4.91 g, 23.15 mmol), Pd(PPh3)4 (0.534 mg, 0.46 mmol) and water (5 mL). The reaction mixture was heated at 90 C. for 1 h and water was added to the mixture to induce precipitation. The precipitate was isolated by filtration and was purified by column chromatography (silica gel, eluent petroleumether/EtOAc 1:1) to afford of 4-(6-bromoimidazo[1,2-a]pyrazin-3-yl)benzonitrile (2.5 g, 90%) as an off-white solid. 1H NMR (400 MHz, DMSO-d6) delta 9.88 (s, 1H), 8.90 (s, 1H), 8.27 (s, 1H), 8.05-7.99 (m, 4H); MS (ESI) m/z 301.1 [C13H7BrN4+2]+.

Discovery of 1245644-42-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, its application will become more common.

Application of 1245644-42-1,Some common heterocyclic compound, 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, molecular formula is C6H3BrIN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: [0199] A suspension of tributyl(R2)stanne (3.11 mmol), 6-bromo-3-iodo-imidazo[1,2-a]pyrazine 17* (3.11 mmol) andPd(PPh3)4 (0.93 mmol) in dioxane (20 mL) was heated to 150 C in a microwave tube for 20 minutes. The resultingmixture was filtered through celite and evaporated under reduced pressure. If necessary, the reaction was then carriedout more times on the same scale. The crude products were combined and purified by flash chromatography to give theintermediate 18*.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel; Falcenberg, Mathias; EP2818471; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Brief introduction of 1245644-42-1

General procedure: [0194] 6-bromo-3-iodo-imidazo[1,2-a]pyrazine 17* (0.648 g, 2 mmol) was added to a degassed mixture of dioxane(10 ml) and water (1.5 ml). The aromatic boronic acid (R2B(OH)2) (2.2 mmol) was added followed by palladium acetate(0.022 g, 5 mol%), triphenyl phosphine (0.025 g, 5 mol%) and sodium carbonate (0.32 g, 3 mmol). The reaction mixturewas stirred at 80 C under nitrogen for 18 hours. The solvent was evaporated in vacuo and the residue was partitionedbetween water (20 ml) and dichloromethane (50 ml). The dichloromethane was separated, dried over magnesium sulphateand evaporated in vacuo. The residue was purified by flash chromatography.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel; Falcenberg, Mathias; EP2818471; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Extracurricular laboratory: Synthetic route of 1245644-42-1

The synthetic route of 1245644-42-1 has been constantly updated, and we look forward to future research findings.

Application of 1245644-42-1, These common heterocyclic compound, 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.