Category: 123-32-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123-32-0, name is 2,5-Dimethylpyrazine, A new synthetic method of this compound is introduced below., 123-32-0

General procedure: Using a nitrogen-filled glove box, an oven-dried Schlenk tube (100mL volume) was charged with a magnetic stirring bar, MnO2 (0.05mmol), KOH (0.5mmol), alcohols (1) (0.55mmol), heteroarenes (2) (0.5mmol) and t-AmOH (1mL). Then the Schlenk tube was closed tightly with a Teflon cap, removed from the glove box. A reflux condenser was evacuated and refilled with dry air and then attached to the Schlenk tube maintaining dry air stream. A bubble counter was attached to the top of the condenser and the whole system was purged with dry air for 15s. The Schlenk tube was immersed into a pre-heated oil bath (design temperature). After design time the reaction was cooled, a small aliquot of the organic phase was analyzed by GC or GC-MS to monitor product formation. Purification of the remainder by column chromatography on silica gel (petroleum ether/ethyl acetate=20/1-5/1) gave the corresponding products in the reported yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhang, Chunyan; Li, Zehua; Fang, Yanchen; Jiang, Shaohua; Wang, Maorong; Zhang, Guoying; Tetrahedron; vol. 76; 11; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123-32-0, name is 2,5-Dimethylpyrazine, A new synthetic method of this compound is introduced below., 123-32-0

Preparation of 3,6-dimethyl-2- (3-chloro) benzoyl pyrazine, comprising the steps of:(1) 2,5-dimethyl pyrazine take 0.2mmol, 3- chloro-benzoyl formate 0.4mmol, silver phosphate 0.02mmol, potassium persulfate 0.4mmol, 1.4mL was added dichloromethane, 0.6mL distilled water after the mixture was made, and the mixture was placed in a reaction tube in 5mL, placed in an oil bath at 40 heated, the reaction 24h, cooled to room temperature to obtain a reaction solution;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with ethyl acetate / petroleum ether = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 37mg target The product, 74% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Li Yuan; (10 pag.)CN108101856; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

123-32-0, Adding some certain compound to certain chemical reactions, such as: 123-32-0, name is 2,5-Dimethylpyrazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123-32-0.

The title compound was synthesized by the reaction of 2,5-dimethylpyrazine with 4-(dimethylamino)benzaldehyde (Scheme 1). A solution of 2,5-dimethylpyrazine (0.5 g, 4.62 mmol) and the 4-(dimethylamino)benzaldehyde (2.3 g, 13 mmol) were dissolved in DMF and the mixture was cooled to 0 C. To this mixture potassium-tert-butanolate (1.55 g, 13 mmol) was added in small portions and the mixture was brought to ambient temperature. Stirring was continued until all starting material had been consumed (TLC). After the completion of the reaction, water was added, and the product was isolated by extraction with chloroform. The organic layer was concentrated in vacuum and the solid material obtained was recrystallized to give the product (1.4 g, 52%) as ared solid. The structure of the compound was confirmed by IR, 1HNMR and 13C NMR.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 123-32-0.

Reference:
Article; Asiri, Abdullah M.; Alamry, Khalid A.; Pannipara, Mehboobali; Al-Sehemi, Abdullah G.; El-Daly, Samy A.; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 149; (2015); p. 722 – 730;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 123-32-0 name is 2,5-Dimethylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 123-32-0

54 g (498 mmol) of 2,5-dimethylpyrazine (manufactured by Tokyo Chemical Industry Co., Ltd.) and 224 g (2.02 mol) of selenium dioxide were added to 840 ml of a mixed solution of pyridine and water (mixing mass ratio: 20/1) And the mixture was heated under reflux for 48 hours. The reaction solution was cooled to ambient temperature and filtered, and the filtration residue was washed with a mixed solution of pyridine and water (mixing mass ratio: 20/1), the filtrate and the washing solution were combined and the liquid was distilled off to obtain a solid It was.The resulting solid was dispersed in 2 M dimethylamine aqueous solution used as an extraction solvent, and residual solids were removed from the extract by filtration. By distilling off the solvent from the extract, 71 g (yield 85%) of 2,5-pyrazinedicarboxylic acid (3) was obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,5-Dimethylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; IHI Corporation; Waseda University; Sato, Yutaka; Kanomata, Norihiro; Yuchi, Takeshi; (19 pag.)JP2018/140981; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem