Category: 123-32-0

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 123-32-0, Name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2. In an article, author is Karmakar, Ananta,once mentioned of 123-32-0, SDS of cas: 123-32-0.

Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a ]pyrazines from alpha-Aminoacetonitriles

An efficient and practical synthetic protocol for the synthesis of 1,4-disubstituted pyrrolo[1,2- a ]pyrazine derivatives is described that originates from alpha-substituted pyrroloacetonitriles which, in turn, are readily available from aryl and alkyl aldehydes. The alpha-pyrroloacetonitriles were subjected to a Friedel-Crafts acylation with methyl chlorooxoacetate followed by reduction of the nitrile group under Pd-catalyzed hydrogenation conditions and finally aromatization with DDQ leading to the desired pyrrolo[1,2- a ]pyrazine derivatives. This method was generalized and successfully applied to various aryl, heteroaryl, and alkyl substrates. The developed protocol provides direct and convenient access to 1,4-disubstituted ring systems in moderate to good overall yields (51-68%) without the need for purification of the intermediates. Further functionalization via the stepwise halogenation (bromination, iodination) and nitration was also demonstrated. In addition, the potential of the ester functionality for elaboration was demonstrated by manipulating into heterocyclic ring systems, exemplified by conversion into benzoxazole derivatives.

Interested yet? Keep reading other articles of 123-32-0, you can contact me at any time and look forward to more communication. SDS of cas: 123-32-0.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C6H8N2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 123-32-0, Name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2. In an article, author is Zhu, Meiqing,once mentioned of 123-32-0.

A novel pyrene-based fluorescent probe for the rapid and efficient detection of Co2+ in HeLa cells and natural water samples

Excessive levels of Co2+ in the environment can cause serious diseases to humans and affect the growth of crops. Therefore, it is necessary to develop effective methods for monitoring Co2+. In the present work, a novel, low-toxic fluorescent probe, PEPA, for the rapid and efficient detection of Co2+ is synthesized. PEPA shows high sensitivity, with a limit of detection of 0.104 mu M and a fast response to Co2+ (<4 min). The detection mechanism was confirmed by FT-IR. HRMS and DFT calculations. Co2+ can restrict the free rotation of the C=N group and the pyrazine ring of PEPA, resulting in the enhancement of fluorescence. In addition, the recognition process of Co2+ can be realized with the naked eye (i.e., a color change from colorless to blue fluorescence). The successful detection of Co2+ in test strips and environmental water samples provides strong support for its application potential. Interestingly, the recovery rate of Co2+ detected by PEPA can reach 93% after being recovered four times. Importantly, PEPA was suitable for the fluorescence imaging of exogenous Co2+ in HeLa cells. (C) 2020 Elsevier B.V. All rights reserved. If you¡¯re interested in learning more about 123-32-0. The above is the message from the blog manager. Formula: C6H8N2.

Synthetic Route of 123-32-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123-32-0, name is 2,5-Dimethylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

(b) 3,6-Dimethylpyrazin-2-amine[00426] A mixture of 2,5-dimethylpyrazine (14 g, 0.13 mol) in N,N-dimethylaniline (50 mL) was heated to 170 C and NaNH2 (22 g, 0.56 mol) was added in portions. The reaction mixture was stirred at 170 C for 1 h, and the solvent was removed. The product was purified by column chromatography to give 3,6-dimethylpyrazin-2-amine as a brown solid (1.6 g). MS (ESI): m/z 124[M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dimethylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; JONES, Philip; XIE, Linghong; WO2011/150156; (2011); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 123-32-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows.

Example 7 BSc4354: 2,5-Bis(4-methoxystyryl)pyrazine Synthesis: 2,5-Dimethylpyrazine (0.125 g, 1.16 mmol) is dissolved in 10 ml dimethylformamide, followed by addition of 4-methoxybenzaldehyde (0.315 g, 2.32 mmol) and potassium-t-butoxide (0.26 g, 2.32 mmol) The solution is heated for 4 h to 80 C. and allowed to cool to room temperature. In this process, a solid crystallizes out. The solution containing the crystallized solid is filtered and washed with ethyl acetate. After drying under high-vacuum, 0.370 g (yield: 93%) of the product BSc4354 is obtained as yellow solid.1H-NMR (CDCl3, 500 MHz): delta=8.54 (s, 2H), 7.67 (d, J=16 Hz, 2H), 7.55 (d, J=9 Hz, 4H), 7.04 (d, J=16 Hz, 2H), 6.93 (d, J=9 Hz, 4H, 3.85 (s, 6H) ppm13C-NMR (CDCl3, 125 MHz): delta=158.3, 146.9, 141.0, 131.7, 126.7, 120.0, 112.3, 53.4 ppm.

The chemical industry reduces the impact on the environment during synthesis 2,5-Dimethylpyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; KLINIKUM DARMSTADT GMBH; TECHNISCHE UNIVERSITAT DARMSTADT; LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN; Schmidt, Boris; Kieser, Daniel; Bolaender, Alexander; Herms, Jochen; Haussen, Roland Heyny-Von; Gu, Jiamin; US2013/287700; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 123-32-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123-32-0, name is 2,5-Dimethylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A solution of m-CPBA (70% purity, 100.0 g, 405.63 mmol) in ethyl acetate (150 mL) was washed with brine (150 mL). The organic layer was separated, dried over MgSO4 and filtered. The filtrate was added to a solution of 2,5-dimethylpyrazine 2 (20.20 mL, 184.94 mmol) in ethyl acetate (50 mL) and the resulting solution was stirred for 24 h at rt. The white solid precipitated was filtered, washed by ethyl acetate (3×100 mL) and dried to give the title compound 6 (23.5 g, 90%) as a white crystalline solid. M.p.: 286 C (dec.).1 1H MNR (200 MHz, D2O): d 8.48 (s, 2H), 2.42 (s, 6H). 13C MNR (50 MHz, D2O): d 145.8, 136.0, 13.7. HRMS (DCI+CH4) Calcd. for C6H9N2O2 [M+H]+: 141.0664. Found: 141.0674.

The synthetic route of 2,5-Dimethylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Das, Sajal Kumar; Frey, Joseph; Tetrahedron Letters; vol. 53; 30; (2012); p. 3869 – 3872;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H8N2

1), in 125 ml in the reaction bottle, by adding 1.08g (10mmol) 2, 5-dimethyl-pyrazine, 1.13g (4mol) FeSO4¡¤ 7H2O, by adding 30 ml of water (i.e., 3 ml/1mmol), stirring in the ice bath, then measure 0.1mol (6 ml) 98% concentrated sulfuric acid to constant pressure dropping funnel slowly dropping, the temperature change in the process of dropping the attention, to maintain the temperature of the reaction bottle too high (i.e., to control the temperature to 60 C the following can be). After concentrated sulfuric acid instillment , on a rectifier 22mmol (7.5 ml) hydrogen peroxide, PV drop instillment , and to continue the reaction in the ice bath, dripping at any time in the process of observing reaction bottle temperature change (i.e., to control the temperature to 60 C the following can be). After dripping adding 240uL (3mmol) is propionaldehyde, slowly elevated temperature so as to control the temperature to 50-60C, in the reaction 1h, 2h, 3h, 4h are respectively adding 240uL is propionaldehyde. In the reaction process and reaction conditions for TLC, reaction conditions estimated raw material, when the raw material after the reaction is complete can stop the reaction (about 6h).2), stop heating after the reaction, cooling to room temperature, with 30 ml ethyl acetate extraction, the aqueous phase (the lower) the quality of the diluted for the fraction of 20% NaOH to adjust the pH to 8, in the process the alkali adjusting full stirring, not to allow the temperature of the solution is too high (i.e., not to exceed 60 C). Then extracting with ethyl acetate three times, combined with the phase (the upper), pressure-reducing (pressure -0.08–0.10 MPa) concentrated to dry, yellow oily substance is about 1.532 g. Finally through the column chromatography the 2-ethyl -3, 6-dimethyl-pyrazine separated.As follows:The silica gel chromatography (built-in 200-300 purpose silica gel 30g), the resulting 1.532g for column chromatography yellow oily substance; for the mobile phase ethyl acetate: petroleum ether = 1:20 of the mixed solution, the total consumption of mobile phase about 500 ml; final 1.245g product—2-ethyl -3, 6-dimethyl-pyrazine (the purity is 95.6%). Yield 90.88%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 123-32-0.

Reference:
Patent; Zhejiang University; Cheng, Jingli; Wang, Likun; Zhao, Yang; Zhao, Jinhao; (9 pag.)CN105237486; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 123-32-0, name is 2,5-Dimethylpyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123-32-0, Quality Control of 2,5-Dimethylpyrazine

Preparation of 3,6-dimethyl-2- (4-chloro) benzoyl pyrazine, comprising the steps of:(1) 2,5-dimethyl pyrazine take 0.2mmol, 4- chloro-benzoyl formate 0.4mmol, 0.02 mmol silver phosphate, potassium persulfate 5mL reaction tube was placed 0.4mmol, 1.4mL was added dichloro methane, 0.6 mL of distilled water was added, and the mixture was placed in an oil bath at 40 heated, reaction 24h, cooled to room temperature to obtain a reaction solution;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with ethyl acetate / petroleum ether = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 46 mg desired product in 94% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,5-Dimethylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Li Yuan; (10 pag.)CN108101856; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 123-32-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows.

Preparation of 3,6-dimethyl-2- (2-furoyl) pyrazine, comprising the steps of:(1) 2,5-dimethyl pyrazine take 0.2mmol, 2- furylcarboxamido acid 0.4mmol, 0.02 mmol silver phosphate, potassium persulfate 0.4mmol 5mL reaction tube was placed in dichloromethane was added 1.4mL , 0.6 mL of distilled water was added, and the reaction mixture was placed in a 5mL tube and placed in an oil bath at 40 heated, reaction 24h, cooled to room temperature to obtain a reaction solution;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with ethyl acetate / petroleum ether = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 11mg target The product, 27% yield.

The chemical industry reduces the impact on the environment during synthesis 2,5-Dimethylpyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Li Yuan; (10 pag.)CN108101856; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 123-32-0, The chemical industry reduces the impact on the environment during synthesis 123-32-0, name is 2,5-Dimethylpyrazine, I believe this compound will play a more active role in future production and life.

BDPEP laser dye was prepared as follows (Scheme 1); Indimethyl formamide (DMF), a mixture from 2,5-dimethylpyrazine(0.5 g) and 4-(dimethylamino) benzaldhyde (2.3 g) is dissolved.Then, this mixture is cooled to 0 C. A small amount of potassiumtri-butanolate (1.55 g) was added to this mixture while stirringuntil all the raw materials were dissolved. Distilled water changedto introduce after the reaction was completed, and the productturned into isolated with chloroform. The color of the productobtained is red solid (1.4 g, 52%). The structure of the product obtainedis characterized by IR, 1H NMR and 13C NMR [15].1H NMR (CDCl3, 600 MHz): d 3.03 (s, 12H), 6.74 (d,4H,J 8.9 Hz), 6.94 (d,2H,J 16.1 Hz), 7.49 (d, 4H, J 8.9 Hz), 7.64 (d,2H, J 16.1 Hz), 8.49 (s, 2H). 13C NMR (CDCl3, 150 MHz): d 40.3,112.2, 120.7, 127.5, 132.8, 141.7, 148.0, 150.7.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dimethylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Abdel Gawad, Sayed A.; Abou Kana, Maram T. H.; Ebeid, El-Zeiny M.; El-Daly, Samy A.; Sakr, Mahmoud A. S.; Journal of Molecular Structure; vol. 1217; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 123-32-0, name is 2,5-Dimethylpyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123-32-0, Application In Synthesis of 2,5-Dimethylpyrazine

(b) 3,6-Dimethylpyrazin-2-amine A mixture of 2,5-dimethylpyrazine (14 g, 0.13 mol) in N,N-dimethylaniline (50 mL) was heated to 170 C. and NaNH2 (22 g, 0.56 mol) was added in portions. The reaction mixture was stirred at 170 C. for 1 h, and the solvent was removed. The product was purified by silica gel column chromatography to give 3,6-dimethylpyrazin-2-amine as a brown solid (1.6 g, yield 10%). ESI MS: m/z 124 [M+1]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,5-Dimethylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; Sunovion Pharmaceuticals Inc.; US2012/178748; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem