Category: 123-32-0

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 123-32-0

Preparation (benzo [d] [1,3] dioxol-5-yl) (3,6-dimethyl-2-yl) methanone, comprising the steps of : (1) 2,5-dimethyl pyrazine take 0.2mmol, 3,4- methylenedioxy-benzoyl acid 0.4mmol, 0.02 mmol silver phosphate, potassium persulfate 0.4mmol 5mL reaction tube was placed, was added 1.4mL of dichloromethane, 0.6 mL of distilled water was added, and the reaction mixture was placed in a 5mL tube and placed in an oil bath at 40 heated, reaction 24h, cooled to room temperature to obtain a reaction solution;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with petroleum ether / dichloromethane = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 37mg target The product, in 72% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 123-32-0.

Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Li Yuan; (10 pag.)CN108101856; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H8N2

1), in 125 ml in the reaction bottle, by adding 1.08g (10mmol) 2, 5-dimethyl-pyrazine, 1.13g (4mol) FeSO4· 7H2O, by adding 30 ml of water (i.e., 3 ml/1mmol), stirring in the ice bath, then measure 0.1mol (6 ml) 98% concentrated sulfuric acid to constant pressure dropping funnel slowly dropping, the temperature change in the process of dropping the attention, to maintain the temperature of the reaction bottle too high (i.e., to control the temperature to 60 C the following can be). After concentrated sulfuric acid instillment , on a rectifier 22mmol (7.5 ml) hydrogen peroxide, PV drop instillment , and to continue the reaction in the ice bath, dripping at any time in the process of observing reaction bottle temperature change (i.e., to control the temperature to 60 C the following can be). After dripping adding 240uL (3mmol) is propionaldehyde, slowly elevated temperature so as to control the temperature to 50-60C, in the reaction 1h, 2h, 3h, 4h are respectively adding 240uL is propionaldehyde. In the reaction process and reaction conditions for TLC, reaction conditions estimated raw material, when the raw material after the reaction is complete can stop the reaction (about 6h).2), stop heating after the reaction, cooling to room temperature, with 30 ml ethyl acetate extraction, the aqueous phase (the lower) the quality of the diluted for the fraction of 20% NaOH to adjust the pH to 8, in the process the alkali adjusting full stirring, not to allow the temperature of the solution is too high (i.e., not to exceed 60 C). Then extracting with ethyl acetate three times, combined with the phase (the upper), pressure-reducing (pressure -0.08–0.10 MPa) concentrated to dry, yellow oily substance is about 1.532 g. Finally through the column chromatography the 2-ethyl -3, 6-dimethyl-pyrazine separated.As follows:The silica gel chromatography (built-in 200-300 purpose silica gel 30g), the resulting 1.532g for column chromatography yellow oily substance; for the mobile phase ethyl acetate: petroleum ether = 1:20 of the mixed solution, the total consumption of mobile phase about 500 ml; final 1.245g product—2-ethyl -3, 6-dimethyl-pyrazine (the purity is 95.6%). Yield 90.88%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 123-32-0.

Reference:
Patent; Zhejiang University; Cheng, Jingli; Wang, Likun; Zhao, Yang; Zhao, Jinhao; (9 pag.)CN105237486; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 123-32-0,Some common heterocyclic compound, 123-32-0, name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2, 5-dimethylpyrazine (6 g, 55.6 mmol), carbon tetrachloride (50 mL) were added in a three-necked flask,After stirring, N-chlorosuccinimide (NCS) (7. 4 g, 55.6 mmol) and benzoyl peroxide(0. 05 g, 0.21 mmol),The reaction mixture was irradiated under incandescent light,Stir,Reflux reaction about 18h,TLC [V (ethyl acetate): V (petroleum ether) = 1: 2 as developing solvent] After the detection reaction is substantially complete,The reaction solution was cooled to 0 C,After standing for 1 hour,filter,The filter cake is washed with cold carbon tetrachloride,Combined filtrate and wash solution,Vacuum distillation of carbon tetrachloride,Get a light brown oil,Methylene chloride dissolved,After decolorization of activated carbon,Pale yellow oil,Without further direct reaction to the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5-Dimethylpyrazine, its application will become more common.

Reference:
Patent; Anhui University of Chinese Medicine; Hefei Industrial Pharmaceutical Institute Co., Ltd.; Li, JiaMing; He, GuangWei; Hu, MinHua; Huang, WeiJun; Zhu, Xiaoyu; Wang, Jie; Ye, WenFeng; Zhang, EnLi; (10 pag.)CN103664804; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 123-32-0, name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 123-32-0

(b) 3,6-Dimethylpyrazin-2-amine A mixture of 2,5-dimethylpyrazine (14 g, 0.13 mol) in N,N-dimethylaniline (50 mL) was heated to 170 C. and NaNH2 (22 g, 0.56 mol) was added in portions. The reaction mixture was stirred at 170 C. for 1 h, and the solvent was removed. The product was purified by silica gel column chromatography to give 3,6-dimethylpyrazin-2-amine as a brown solid (1.6 g, yield 10%). ESI MS: m/z 124 [M+1]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 123-32-0, its application will become more common.

Reference:
Patent; Sunovion Pharmaceuticals Inc.; US2012/178748; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 123-32-0

2,5-Dimethylpyrazine (0.99 g, 9.15 mmol), benzaldehyde( 4.00 mL, 39.4 mmol) and benzoic anhydride (4.97 g,22.0 mmol) were stirred in a microwave tube until full dissolution occurred. Argon was bubbled through the yellow mixture and was reacted at 175 C in the microwave for 5 h,with rapid stirring. After cooling, a dark brown solid was obtained, which was suspended in cold ethanol before filtering and washing with cold ethanol to yield a yellow crystalline solid (1.61 g, 5.7 mmol, 62%). This product was carriedthrough to the next reaction without further purification. 1HNMR (500 MHz, CDCl3):delta 8.60 (2H, s, ArH), 7.74 (2H, d,J = 16 Hz, CH), 7.63-7.59 (4H, m, ArH), 7.43-7.31 (6H, m,ArH), 7.19 (2H, d, J = 16 Hz, CH).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 123-32-0.

Reference:
Article; Dais, Tyson N.; Brown, Michael J.; Coles, Martyn P.; Laur, Francois; Price, Jason R.; Rowlands, Gareth J.; Plieger, Paul G.; Journal of Inclusion Phenomena and Macrocyclic Chemistry; vol. 94; 3-4; (2019); p. 175 – 182;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 123-32-0, A common heterocyclic compound, 123-32-0, name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,5-dimethylpyrazine (0.5 g, 0.00462 mol) and 1-methylpyr-role-2-carboxaldehyde (1.513 g, 0.0138 mol) were dissolved in DMFand the mixture was cooled to 0 C (Scheme 1). To this mixture,potassium-tert-butanolate (1.55 g, 0.013 mol) were added in smallportions and the mixture was brought to ambient temperature andstirring was continued until all starting material had beenconsumed (TLC). After the completion of the reaction, waterwas added, and the product was isolated by extraction withchloroform. The organic layer was concentrated in vacuum and thesolid material obtained was recrystallized to give the product(1.2 g, 42%) as an orange solid. The structure of the compound wasconfirmed by IR and 1H and 13C NMR techniques.1H NMR (CDCl3, 500 MHz): delta = 3.7 (s, 6H), 6.16 (m, 2H), 6.64 (m,2H), 6.72 (m, 2H), 6.86 (d, 2H, J = 15.4 Hz), 7.60 (d, 2H, J = 15.4 Hz),8.42 (s,2H). 13C NMR (CDCl3, 150 MHz): delta = 34.2, 107.9, 108.2, 119.3,120.6, 122.1, 128.5, 140.1, 147.8.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; El-Daly, Samy A.; Asiri, Abdullah M.; Alamry, Khalid A.; Osman, Osman I.; Journal of Photochemistry and Photobiology A: Chemistry; vol. 312; (2015); p. 64 – 72;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2,5-Dimethylpyrazine

A method for preparing 5-methylpyrazine-2-carboxylic acid by catalytic oxidation, firstly, diatomaceous earth, manganese chloride, sodium tungstate,Cobalt nitrate and distilled water were added to the reactor at the following element mass ratio: diatomaceous earth: Mn:W:Co:H2O=1:0.09:0.08:0.14:50,Magnetically stirring at room temperature to make it dispersed and uniformly adsorbed, and then removing water by evaporation.Adding a liquid silica sol with a total mass of 5% of the solid sample and kneading it into a small granular sample of 1-2 mm.The mixture was placed in a muffle furnace and calcined in an air atmosphere at 600 C for 5 hours to obtain Mn-W-Co/diatomaceous earth-supported catalyst particles.10 g of Mn-W-Co/diatomaceous earth catalyst particles were packed into a fixed bed microreactor reaction tube, and the reactor was heated to 330 C.The reaction raw material 2,5-dimethylpyrazine was introduced into a fixed bed reaction tube by bubbling with high-temperature steam at 10 ml/min.Oxygen is introduced into the reaction tube separately at 20 ml/min to cause catalytic oxidation of 2,5-dimethylpyrazine in the catalytic bed.The 5-methylpyrazine-2-carboxylic acid is produced and taken out of the reaction tube by water vapor, condensed, crystallized, and collected.Analysis of 5-methylpyrazine-2-carboxylic acid by gas chromatographyThe yield was 75.6%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 123-32-0.

Reference:
Patent; Lanzhou University; Dong Zhengping; (6 pag.)CN109369544; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 123-32-0

Preparation of 3,6-dimethyl-2- (3-bromo) benzoyl pyrazine, comprising the steps of:(1) 2,5-dimethyl pyrazine take 0.2mmol, 3- bromo-benzoyl formic 0.4mmol, silver phosphate 0.02mmol, potassium persulfate 0.4mmol, 1.4mL was added dichloromethane, 0.6mL distilled water after the mixture was made, and the mixture was placed in a reaction tube in 5mL, placed in an oil bath at 40 heated, the reaction 24h, cooled to room temperature to obtain a reaction solution;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with ethyl acetate / petroleum ether = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 22mg target The product, in 37% yield.

According to the analysis of related databases, 123-32-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Li Yuan; (10 pag.)CN108101856; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 123-32-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123-32-0, name is 2,5-Dimethylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Preparation of 3,6-dimethyl-2- (4-isopropyl) benzoyl pyrazine, comprising the steps of: (1) 2,5-dimethyl pyrazine take 0.2mmol, 4- benzoyl-carboxylic acid isopropyl 0.4mmol, 0.02 mmol silver phosphate, potassium persulfate 5mL reaction tube was placed 0.4mmol, 1.4mL was added di methylene chloride, 0.6 mL of distilled water was added, and the mixture was placed in an oil bath at 40 heated, reaction 24h, cooled to room temperature to obtain a reaction solution;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with ethyl acetate / petroleum ether = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 20 mg desired product in 40% yield.

The synthetic route of 2,5-Dimethylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Li Yuan; (10 pag.)CN108101856; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 123-32-0,Some common heterocyclic compound, 123-32-0, name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

he 2,5-dimethyl pyrazine (1.08g, 10mmol), methanol (30ml, 742mmol) and 30% sulfuric acid (47ml, 175.4mmol) was added 500ml of four-necked flask, stirring speed, ambient temperature and pressure At the same time at the same speed inwardly slowly dropped 30% H2O2(7ml, 68.4mmol) and a saturated aqueous solution of ferrous sulfate (6.35g, 22.8mmol), the reaction temperature is controlled at 30 ~ 60 , addition was complete, the reaction was completed.The reaction solution was adjusted with sodium hydroxide to pH = 9, was centrifuged, the precipitate portion was washed once with water, the combined aqueous layer was concentrated to dryness, and extracted three times respectively, filtration, filtrate was washed with 250ml of ethyl acetate was distilled under reduced pressure to recover the solvent, the crude product was liguzinediol , column chromatography on silica gel, petroleum ether: ethyl acetate = 3 eluted, recrystallized from ethyl acetate to give white needle crystals 0.52g, yield 31%, purity 99.3%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5-Dimethylpyrazine, its application will become more common.

Reference:
Patent; Nanjing University of Chinese Medicine; Li, Wei; Wen, Hong Mei; Wang, Tianlin; Zhou, Ying; Chen, Lei; (6 pag.)CN103242247; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem