Category: 122-05-4

122-05-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

5 mmol of (2FPpy)2Ir(Cl)2Ir(2FPpy)2, 25 mmol of pyrazine-2,5-dicarboxylic acid (Py2CA), and 50 mmol of potassium carbonate were mixed in 100 mL of 1,2-dichloroethane, and refluxed for 24 hours under a nitrogen atmosphere. After the reaction was complete, the solution was cooled down to about 50 C., and filtrated. The filtrated solution was purified by using column chromatography to thereby produce (2FPpy)2Ir(Py2CA)Ir(2FPpy)2 at a yield of 86%.

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Reference:
Patent; SAMSUNG ELECTRONICS CO., LTD.,; US2008/269484; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

122-05-4, Name is Pyrazine-2,5-dicarboxylic acid, 122-05-4, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

Pyrazine-2,5-dicarboxylic acid (0.58 g; 3.42 mmol), anhydrous HOBt (0.69 g; 5.13 mmol) and l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.98 g: 5.13 mmol) were added to 5 ml of DCM. 2-(5-(3,4-dichlorophenyl)furan-2-yl)- ethanamine hydrochloride (1.0 g; 3.42 mmol) and DIPEA (0.89 ml; 5.13 mmol) were dissolved in 5 ml of DCM and added dropwise to the previous mixture. The reaction mixture was stirred overnight after which pyrazine-2,5-dicarboxylic acid (0.58 g; 1.59 mmol) and DIPEA (0.60 ml; 3.42 mmol) were added and the mixture was again stirred for 5 h. Anhydrous HOBt (0.69 g; 5.13 mmol), l-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride (0.98 g: 5.13 mmol) and DIPEA (0.89 ml; 5.13 mmol) were again added to drive the reaction to completion. After overnight stirring the mixture was diluted with 20 ml of DCM and washed with 3×10 ml water. The organic phase was dried over Na2S04, filtered and used as such without further purification.

Statistics shows that Pyrazine-2,5-dicarboxylic acid is playing an increasingly important role. we look forward to future research findings about 122-05-4.

Reference:
Patent; ORION CORPORATION; WOHLFAHRT, Gerd; TOeRMAeKANGAS, Olli; SALO, Harri; HOeGLUNG, Lisa; KARJALAINEN, Arja; KNUUTTILA, Pia; HOLM, Patrick; RASKU, Sirpa; VESALAINEN, Anniina; WO2011/51540; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Pyrazine-2,5-dicarboxylic acid (900 mg, 5.35 mmol) was dissolved in MeOH (9 mL) and Hydrogen chloride ~1.25M solution in Methanol (9 mL) was added. Then the mixture was heated to 50 C and stirred at that temperature for 8 hrs. Then it was left stirring at RT overnight. The day after 2 mL more of HCI ~1.25 M in MeOH was added and the mixture heated to 50 C and stirred at that temperaure for further 1 h. The mixture was cooled down to RT and concentrated under reduced pressure affording 2,5-dimethyl pyrazine-2,5- dicarboxylate (p139, 949 mg, y= 90%). MS (m/z): 197.1 [MH]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2,5-dicarboxylic acid, its application will become more common.

Reference:
Patent; INDIVIOR UK LIMITED; CREMONESI, Susanna; MICHELI, Fabrizio; SEMERARO, Teresa; TARSI, Luca; (364 pag.)WO2016/67043; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

122-05-4, The chemical industry reduces the impact on the environment during synthesis 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, I believe this compound will play a more active role in future production and life.

A solution of ScCl3¡¤6H2O (30 mg, 0.116 mmol) in distilled water(1.0 ml) was mixed with a solution of H2pzc dihydrate (35 mg, 0.171 mmol) in N,N-dimethylacetamide (1.0 ml). Acetonitrile(2.0 ml) and 0.25 ml of concentrated hydrochloric acid were added to the mixture. The prepared reaction mixture was placedinto a sealed glass tube and kept at 100 C for 48 h. The obtained colorless needle-like crystals were filtered off, washed bytwo portions (2 ml) of acetonitrile and dried in air. The product yield was 18 mg (43%). Elemental analysis: found (%)C 37.2, H 2.8, N 15.2. Calculated for C22H18N8O15Sc2 (%): C 36.8, H 2.5, N 15.5. IR spectrum (KBr), v, cm-1: 417 (w),489 (m), 509 (m), 532 (m), 510 (w), 773 (s), 845 (s), 949 (w), 1016 (w), 1051 (s), 1180 (s), 1200 (w), 1298 (s), 1385 (s),1479 (s), 1666 (s), 2250 (w), 2816 (w), 3100 (w), 3375 (w), 3470 (w).

The chemical industry reduces the impact on the environment during synthesis Pyrazine-2,5-dicarboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Article; Barsukova; Sapianik; Samsonenko; Fedin; Journal of Structural Chemistry; vol. 60; 5; (2019); p. 823 – 829; Zh. Strukt. Kim.; vol. 60; 5; (2019); p. 857 – 863,7;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem