Category: 122-05-4

Reference of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: To a solution of { (S)-1 – [(S)-1 -(6-bromo-2-methoxy-naphthalen- 1 -ylmethyl)-2- oxo-2,3 ,4,5-tetrahydro- 1 H-benzo [b] [1,4] diazepin-3-ylcarbamoyl] -ethyl } -methyl-carbamic acid tert-butyl ester (Intermediate 11) (300 mg, 0.49 mmol) and pyrazine-2,5-dicarboxylic acid (41.2mg, 0.24 mmol) in pyridine (5 mL) at 0 C was added POC13 (46 tL, 0.49mmol) and the cooling bath removed. After 5 h, the mixture was diluted with dichloromethane, washed with water, dried (Na2504) and concentrated. The residue was purified by preparative reverse phase HPLC to afford tert-butyl N- [(1 S)-2- [[(35)-5- [(6-bromo-2-methoxy- 1 -naphthyl)methyl] -1- [5-[(35)-5- [(6-bromo-2-methoxy- 1 -naphthyl)methyl] -3- [[(2S )-2- [tert15 butoxycarbonyl(methyl)amino]propanoyl] amino] -4-oxo-2,3-dihydro- 1,5 -benzodiazepine- 1-carbonyl]pyrazine-2-carbonyl] -4-oxo-2,3-dihydro- 1,5 -benzodiazepin-3-yl] amino] -1 -methyl-2- oxo-ethyl]-N-methyl-carbamate (52 mg, 7.82 %) as an off white solid. LC-MS: 1355.0 (M+H).

The synthetic route of 122-05-4 has been constantly updated, and we look forward to future research findings.

Application of 122-05-4, These common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Diacid 64 was prepared from the corresponding pyrazine 82. Synthesis of pyrazine-2,5-dicarboxylic acid 82 had been reported by several authors.

Statistics shows that Pyrazine-2,5-dicarboxylic acid is playing an increasingly important role. we look forward to future research findings about 122-05-4.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 122-05-4

General procedure: 3.1.1.12; 2,5-Bis[6-(4,5-dihydro-1H-imidazol-2-yl)1,3-benzothiazol-2-yl]pyrazine dihydrochloride (3l) To a solution of the free base prepared by method A in acetic acid (40 mL) concd HCl (2.0 mL) was added and stirred for 2 h. The resulting precipitate was filtered off, washed with acetone and dried. Crystallization from water/1 M HCl/acetone mixture gave pure compound 3l 136 mg (46.0%) as yellow solid: mp > 300 C. 1H NMR (300 MHz, DMSO-d6) (delta ppm): 10.65 (br s, 4H, H-Amd), 9.70 (s, 2H, H-Pyr), 8.86 (d, 2H, J = 1.4 Hz, H-Bt), 8.48 (d, 2H, J = 8.7 Hz, H-Bt), 8.10 (dd, 2H, J = 1.5 Hz, J = 8.6 Hz, H-Bt), 4.06 (s, 8H, H-CH2). LC-MS (ESI) m/z: 483.3 [(M + H+) calcd for free base C24H18N8S2, 482.11]. Analysis calcd for C24H20Cl2N8S2 * 2H2O (591.54): C, 48.73; H, 4.09; N, 18.94, Cl, 11.99. Found C, 48.91; H, 4.05; N, 18.94; Cl, 11.72%.

The synthetic route of 122-05-4 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 122-05-4

5 mmol of (PBTZ)2Ir(Cl)2Ir(PBTZ)2, 25 mmol of pyrazine-2,5-dicarboxylic acid (Py2CA), and 50 mmol of potassium carbonate were mixed in 100 mL of 1,2-dichloroethane, and refluxed for 24 hours under a nitrogen atmosphere. After the reaction was complete, the solution was cooled down to about 50 C. and filtrated. The filtrate solution was purified by using column chromatography to thereby produce (PBTZ)2Ir(Py2CA)Ir(PBTZ)2 at a yield of 82%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 122-05-4.

Reference:
Patent; SAMSUNG ELECTRONICS CO., LTD.,; US2008/269484; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

270 mg (1 mmol) of FeCl3.6H2O (Alfa Aesar, 98%) and 204 mg (1 mmol) of 2,5-pyrazinedicarboxylic acid (Aldrich, 98%) are dispersed in 5 ml of DMF (Fluka, 98%) with 0.05 ml of 5M HF (SDS, 50%). The mixture is left in a 23 ml Teflon vessel inserted into a metallic PAAR type bomb for 3 days at 100 C. The solid is recovered by filtration.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2,5-dicarboxylic acid, its application will become more common.

Reference:
Patent; Universite De Caen-Basse Normandie; Centre National De La Recherche Scientifique- CNRS-; US2011/172412; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sulfuric acid (19 mu, 0.36 mmol) was added to a methanol (1.2 mL, 29 mmol) solution of pyrazine-2,5-dicarboxylic acid (Ark Pharma cat AK-76746, 100 mg, 0.6 mmol). Then the mixture was allowed to stir at 90 C overnight. After cooling to rt, the mixture was diluted with methanol and basified with NaOH aq. Then the mixture was allowed to stir at rt for 5 h to reach -50% conversion to afford the mono-ester. Then the mixture was acidified with HC1 aq, and extracted with DCM/iPrOH x 3. The organic layer was dried and concentrated to afford desired product, which was used in the next step without further purification. LC-MS calculated for C7H7N2O4 (M+H)+: m/z = 183.0; found 183.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2,5-dicarboxylic acid, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; WU, Liangxing; YU, Zhiyong; ZHANG, Fenglei; YAO, Wenqing; (173 pag.)WO2017/106634; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122-05-4, SDS of cas: 122-05-4

9.35 g (167 mmol) of potassium hydroxide and 11 g (65 mmol) of 2,5-pyrazinedicarboxylic acid (3) were dissolved in water (200 ml). To this solution, 5% Pd / C catalyst was added at a rate of 5 mol% with respect to the reaction substrate, hydrogen (1 MPa) was supplied while heating to 50 C.And the hydrogenation reaction was carried out for 18 hours. It was confirmed with a gas chromatograph that raw materials were consumed and the reaction proceeded quantitatively. An aqueous solution of the product was obtained by filtering the reaction solution to remove the catalyst. This product has a measurement result obtained by 1 H NMR measurement in the reference (Witichemistry described in J. Med. Chem. 1985, 28, 1228-1234), ak, DT; Nair, RV; Schmid, FA, “Synthesis and antimetastatic properties of stereoisomeric tricyclic bis (dioxopiperazines) in the Lewis lung carcinoma model” By agreement with the shift value, it was confirmed that it was 2,5-piperazine dicarboxylic acid (4).

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Reference:
Patent; IHI Corporation; Waseda University; Sato, Yutaka; Kanomata, Norihiro; Yuchi, Takeshi; (19 pag.)JP2018/140981; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

After dissolving 76.8 mmol of I2 in 70 ml of pyridine, was added to a 250 ml three-necked flask and heated to 100 C under a nitrogen atmosphere, A solution of 120 ml of pyridine (completed in 4 hours) containing 27.41 mmol of 2,5-dicarboxylic acid pyrazine was slowly added dropwise, After completion of the dropwise addition, heating was continued for 2 hours, cooled, filtered and washed with 50 ml of ether to give a brown powder solid. The powder solids were then placed in a round bottom flask and 150 ml of methanol was added, heated to reflux for 1 h, cooled, filtered, Followed by washing with 40 ml of methanol and 40 ml of diethyl ether to give a brown powder as an intermediate 2,5-dicarboxylic acid pyrazine pyridinium iodide.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2,5-dicarboxylic acid, its application will become more common.

Reference:
Patent; Zhengzhou University of Light Industry; LI, XILI; ZHOU, LIMING; LI, CAIFENG; GAO, LIJUN; FANG, SHAOMING; (15 pag.)CN103896972; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 122-05-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 122-05-4 as follows.

A mixture of pyrazine-2, 5-dicarboxylic acid (4.0Og, 23.79mmol) and hydrochloric acid (1 M in ethanol) was sealed in a pressure vessel and heated to 800C for 48 hours. The cloudy mixture was filtered through a short pad of celite and the filtrate was concentrated under vacuum. The residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated under vacuum to obtain the title compound (1.84g). MS (ESI) m/z 225.0 [M+H]+

According to the analysis of related databases, 122-05-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; N.V. ORGANON; WO2009/24550; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5 mmol of (SPBOZ)2Ir(Cl)2Ir(SPBOZ)2, 25 mmol of pyrazine-2,5-dicarboxylic acid (Py2CA), and 50 mmol of potassium carbonate were mixed in 100 mL of 1,2-dichloroethane, and refluxed for 24 hours under a nitrogen atmosphere. After the reaction was complete, the solution was cooled down to about 50 C., and filtrated. The filtrated solution was purified by using column chromatography to thereby produce (SPBOZ)2Ir(Py2CA)Ir(SPBOZ)2 at a yield of 90%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2,5-dicarboxylic acid, its application will become more common.

Reference:
Patent; SAMSUNG ELECTRONICS CO., LTD.,; US2008/269484; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem