Category: 122-05-4

These common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Pyrazine-2,5-dicarboxylic acid

Dimethyl Pyrazine-2,5-dicarboxylate (83). Hydrogen chloride gas was bubbled (approx. 5 min) into a stirred suspension of 82 (0.5 g, 2.97 mmol) in methanol (25 ml) and the mixture refluxed for 4 hours. Solvent was evaporated under reduced pressure and the residual solid dissolved in chloroform. The chloroform solution was washed with 10% sodium carbonate solution and water, dried (MgSO4) and evaporated under reduced pressure. Solid obtained was recrystallized from methanol to afford 0.42 g (72.2%) of colorless needles mp 167-169 C. [lit. Spoerri, P. E. and Erickson, A. J. Amer. Chem. Soc. 1938, 60, 400-402, mp 168-169 C. (sealed capillary)]; IR (KBr) cm-1 1720 (ester); NMR (CDCl3, 90 MHz) delta 4.09 (s, 6H, CO2 CH3), 9.40 (s, 2H, aromatic). Anal. calcd. for C8 H8 N2 O4: C, 48.98; H, 4.11; N, 14.28. Found: C, 48.89; H, 4.33; N, 14.12.

The synthetic route of Pyrazine-2,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Ohio State University; US4871736; (1989); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, A new synthetic method of this compound is introduced below., name: Pyrazine-2,5-dicarboxylic acid

5 mmol of (DMFQ)2Ir(Cl)2Ir(DMFQ)2, 25 mmol of pyrazine-2,5-dicarboxylic acid (Py2CA), and 50 mmol of potassium carbonate were mixed in 100 mL of 1,2-dichloroethane, and refluxed for 24 hours under a nitrogen atmosphere. After the reaction was complete, the solution was cooled down to about 50 C., and filtrated. The filtrated solution was purified by using column chromatography to thereby produce (DMFQ)2Ir(Py2CA)Ir(DMFQ)2 at a yield of 82%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SAMSUNG ELECTRONICS CO., LTD.,; US2008/269484; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 122-05-4

A suspension of pyrazine-2,5-dicarboxylic acid 1 (5 g, 29.7 mmol) and HCl (1.25 M in MeOH, 50 mL, 62.5 mmol) was stirred at 60 C. for 20 h, after which the reaction was complete. The reaction mixture was concentrated on a rotary evaporator. The crude product was suspended in saturated NaHCO3, extracted with 10% MeOH in dichloromethane (DCM, 3*150 mL). The combined organic extracts were dried with Na2SO4, filtered and concentrated to yield dimethyl pyrazine-2,5-dicarboxylate (4.37 g, 22.28 mmol, 74.9% yield). LCMS ESI: calculated for C8H8N2O4=197.0 (M+H+), found 197.0 (M+H+).

According to the analysis of related databases, 122-05-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; POUDEL, Yam B.; He, Liqi; Gangwar, Sanjeev; Posy, Shoshana L.; Sivaprakasam, Prasanna; (38 pag.)US2019/55245; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122-05-4, Product Details of 122-05-4

A ScCl3·6H2O (30 mg, 0.116 mmol) solution in distilled water (1.0 ml)was mixed with a H2pzc dihydrate solution (35 mg, 0.171 mmol) in N,N-dimethylformamide (1.0 ml). Acetonitrile (2.0 ml)and 0.25 ml of concentrated hydrochloric acid were added to the mixture. The prepared reaction mixture was placed intoa sealed glass tube and kept at 100 C for 24 h. The obtained colorless plate-like crystals were filtered off, washed by twoportions (2 ml) of acetonitrile and dried in air. The product yield was 40 mg (89%). Elemental analysis: found (%) C 37.1,H 3.4, N 14.2. Calculated for C24H24N8O16Sc2 (%): C 37.4, H 3.1, N 14.5. IR spectrum (KBr), v, cm-1: 392 (m), 427 (m),490 (m), 510 (s), 530 (s), 694 (m), 776 (s), 846 (s), 950 (w), 1051 (s), 1121 (m), 1179 (s), 1298 (s), 1386 (s), 1477 (s),1673 (s), 2510 (w), 2818 (w), 3104 (w), 3380 (w), 3491 (w).

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Reference:
Article; Barsukova; Sapianik; Samsonenko; Fedin; Journal of Structural Chemistry; vol. 60; 5; (2019); p. 823 – 829; Zh. Strukt. Kim.; vol. 60; 5; (2019); p. 857 – 863,7;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Pyrazine-2,5-dicarboxylic acid 2 was prepared according to the procedure of Schut et al. Compound 2 was esterified with methanol and hydrogen chloride gas to give dimethyl pyrazine-2,5-dicarboxylate 3. A suspension of 3 (2.0 g, 10.19 mmol) in methanol (250 mL) was stirred as a solution of sodium hydroxide (408 mg in 10.1 mL of water) was added. The mixture was then stirred for another 16 h. The solvent was removed under reduced pressure and the resulting solid was dissolved in water and filtered. The filtrate was acidified with 1N HCl, and the precipitated product was collected by filtration and dried under vacuum to give 4, 1.36 g, 73% yield of product as a white solid.

The synthetic route of 122-05-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Agyin, Joseph K.; Santhamma, Bindu; Roy, Sudipa S.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 23; (2013); p. 6455 – 6458;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122-05-4, Safety of Pyrazine-2,5-dicarboxylic acid

For complex 2, a mixture of Co(NO3)26H2O (30mg,0.1mmol), bimb (20 mg, 0.05mmol) and H2pdc (17mg,0.1mmol) was dissolved in 5mL of DMF, and the mixture wasstirred for 30 min in the air. After the addition of 2mL of water,the mixture was transferred and sealed in a 25mL Teflon-linedreactor and heated to 120 C for 72 h, and thereafter cooled toroom temperature at a rate of 5 C/h. Pink block crystals of 2were obtained in 54% based on Co(NO3)26H2O), water byDMF and dried in the air. Anal. Calcd for 2 (C33H25CoN9O5):C, 57.73; H, 3.67; N, 18.36%; Found: C: 57.23; H: 3.61; N:18.92%. IR (KBr, cm1): 3385(m), 2360(w), 1944(w), 1829(w),1610(m), 1583(m), 1534(m), 1446(m), 1398(w), 1315(w),1186(w), 1142(w), 1109(w), 1051(w), 1014(w), 922(w), 905(w),862(w), 810(w), 779(m), 746(w), 709(w), 670(w), 635(w),592(w), 526(w), 477(w), 426(w).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Xu, Su-Peng; Qin, Feng-Ting; Zheng, An-Xiong; Li, Jiang-Tao; Inorganic and Nano-Metal Chemistry; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 122-05-4, The chemical industry reduces the impact on the environment during synthesis 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, I believe this compound will play a more active role in future production and life.

Example 42: Synthesis of (tetrakis(2′,6′-difluoro-2, 3′-bipyridinato)(mu-2,5-pyrazinedicarboxylate) diiridium(III), Abbreviation; [Ir(dfpypy)225PDC]2) [0408] [0409] Under argon atmosphere, into a 30 mL Schlenk flask equipped with a stirrer were placed 31 mg (0.15 mmol) of 2,5-pyrazinedicarboxylic acid, 16 mg (0.30 mmol) of sodium methoxide and 20 ml of methanol. And then, the mixture was reacted under stirring at room temperature for 2 hours. After the solvent was distilled off under reduced pressure, 184 mg (0.15 mmol) of di-mu-chloro-tetrakis(2′,6′-difluoro-2, 3′-bipyridinato) diiridium(III) and 25 ml of 2-ethoxyethanol were added to the residue, and then the resultant mixture was reacted under stirring at 110 C for 20 hours. After the completion of the reaction, the solvent was distilled off under reduced pressure. Subsequently, 30 ml of dichloromethane was added to the concentrate, and then the resultant mixture was filtered. The precipitate collected by filtration was washed with pure water, and then dried under reduced pressure, to provide 166 mg of tetrakis(2′,6′-difluoro-2, 3′-bipyridinato)(mu-2,5-pyrazinedicarboxylate) diiridium(III) as an orange solid. (84%) [0410] Additionally, tetrakis(2′,6′-difluoro-2, 3′-bipyridinato)(mu-2,5-pyrazinedicarboxylate) diiridium(III) had the following properties: [0411] 1H-NMR (400MHz, d-DMF, delta (ppm)); 8.64 (d, 2H), 8.51 (s, 2H), 8.46-8.24 (m, 6H), 8.17 (dt, 2H), 7.92 (dd, 2H), 7.73 (ddd, 2H), 7.15 (ddd, 2H), 6.01 (s, 2H), 5.50 (s, 2H) FD-MS (M/Z): 1316 M+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine-2,5-dicarboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ube Industries, Ltd.; FUJIMURA, Osamu; FUKUNAGA, Kenji; IWASA, Takafumi; TANAKA, Yasuhiro; FUJITA, Harunori; MURAKAMI, Tadashi; HONMA, Takashi; MACHIDA, Toshikazu; KASHIHARA, Natsuko; EP2647642; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 122-05-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

5 mmol of (2FPpy)2Ir(Cl)2Ir(2FPpy)2, 25 mmol of pyrazine-2,5-dicarboxylic acid (Py2CA), and 50 mmol of potassium carbonate were mixed in 100 mL of 1,2-dichloroethane, and refluxed for 24 hours under a nitrogen atmosphere. After the reaction was complete, the solution was cooled down to about 50 C., and filtrated. The filtrated solution was purified by using column chromatography to thereby produce (2FPpy)2Ir(Py2CA)Ir(2FPpy)2 at a yield of 86%.

The chemical industry reduces the impact on the environment during synthesis Pyrazine-2,5-dicarboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; SAMSUNG ELECTRONICS CO., LTD.,; US2008/269484; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 122-05-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a mixture of tris(2-pyridylmethyl)amine, TPA (0.146g, 0.50mmol) and Cu(ClO4)2·6H2O (0.109g, 0.50mmol) dissolved in MeOH (20mL), 2,3-pyrazine-dicarboxylic acid (H2Pyaz2,3-dc) (0.054g, 0.25mmol) which was neutralized with LiOH (0.012g, 0.5mmol) dissolved in 5.0mL H2O was added drop by drop. The resulting solution was heated for 5min on a steam-bath, filtered through Celite and then was allowed to stand at room temperature. The resulting precipitate, which was obtained after four days was collected by filtration and recrystallized from H2O to produe aqua blue single crystals of X-ray quality. These were collected by filtration, washed with propan-2-ol, Et2O and dried in air. (overall yield: 62mg, 25% based on H2Pyaz2,3-dc)

The synthetic route of Pyrazine-2,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Massoud, Salah S.; Louka, Febee R.; Gazzaz, Mohammed A.; Henary, Maher M.; Fischer, Roland C.; Mautner, Franz A.; Polyhedron; vol. 111; (2016); p. 45 – 52;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Pyrazine-2,5-dicarboxylic acid

Dimethyl Pyrazine-2,5-dicarboxylate (83). Hydrogen chloride gas was bubbled (approx. 5 min) into a stirred suspension of 82 (0.5 g, 2.97 mmol) in methanol (25 ml) and the mixture refluxed for 4 hours. Solvent was evaporated under reduced pressure and the residual solid dissolved in chloroform. The chloroform solution was washed with 10% sodium carbonate solution and water, dried (MgSO4) and evaporated under reduced pressure. Solid obtained was recrystallized from methanol to afford 0.42 g (72.2%) of colorless needles mp 167-169 C. [lit. Spoerri, P. E. and Erickson, A. J. Amer. Chem. Soc. 1938, 60, 400-402, mp 168-169 C. (sealed capillary)]; IR (KBr) cm-1 1720 (ester); NMR (CDCl3, 90 MHz) delta 4.09 (s, 6H, CO2 CH3), 9.40 (s, 2H, aromatic). Anal. calcd. for C8 H8 N2 O4: C, 48.98; H, 4.11; N, 14.28. Found: C, 48.89; H, 4.33; N, 14.12.

The synthetic route of Pyrazine-2,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Ohio State University; US4871736; (1989); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem