Category: 121816-79-3

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole, is researched, Molecular C4H4BrN3O2, CAS is 121816-79-3, about Data-Rich Experimentation Enables Palladium-Catalyzed Couplings of Piperidines and Five-Membered (Hetero)aromatic Electrophiles, the main research direction is data experimentation palladium catalyzed coupling piperidine heterocyclic electrophile.HPLC of Formula: 121816-79-3.

To circumvent a current limitation in palladium-catalyzed C-N cross-coupling methodol., high-throughput experimentation was used to identify a catalyst capable of fusing piperidine-based nucleophiles with five-membered (hetero)aromatic bromides. A decomposition pathway for the standard electrophile was found, and a base screen was used to identify conditions that suppress this undesired transformation. Building on this, systematic optimization using a Design of Experiments approach delivered mild reaction conditions that were then subsequently applied to a variety of coupling partners.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard, published in 1998-07-07, which mentions a compound: 121816-79-3, mainly applied to chloroethylaminonitroimidazole preparation hypoxia selective cytotoxicity; nitroimidazole mustard preparation hypoxia selective cytotoxicity; imidazole chloroethylaminonitro preparation hypoxia selective cytotoxicity, Product Details of 121816-79-3.

A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2-nitroimidazole from 1-methyl-2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23862 in UV4 cells (ca. 40-fold), and superior selectivity (>7-fold) in repair-competent AA8 cells.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole, is researched, Molecular C4H4BrN3O2, CAS is 121816-79-3, about Data-Rich Experimentation Enables Palladium-Catalyzed Couplings of Piperidines and Five-Membered (Hetero)aromatic Electrophiles.HPLC of Formula: 121816-79-3.

To circumvent a current limitation in palladium-catalyzed C-N cross-coupling methodol., high-throughput experimentation was used to identify a catalyst capable of fusing piperidine-based nucleophiles with five-membered (hetero)aromatic bromides. A decomposition pathway for the standard electrophile was found, and a base screen was used to identify conditions that suppress this undesired transformation. Building on this, systematic optimization using a Design of Experiments approach delivered mild reaction conditions that were then subsequently applied to a variety of coupling partners.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sather, Aaron C.; Martinot, Theodore A. researched the compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole( cas:121816-79-3 ).Recommanded Product: 121816-79-3.They published the article 《Data-Rich Experimentation Enables Palladium-Catalyzed Couplings of Piperidines and Five-Membered (Hetero)aromatic Electrophiles》 about this compound( cas:121816-79-3 ) in Organic Process Research & Development. Keywords: data experimentation palladium catalyzed coupling piperidine heterocyclic electrophile. We’ll tell you more about this compound (cas:121816-79-3).

To circumvent a current limitation in palladium-catalyzed C-N cross-coupling methodol., high-throughput experimentation was used to identify a catalyst capable of fusing piperidine-based nucleophiles with five-membered (hetero)aromatic bromides. A decomposition pathway for the standard electrophile was found, and a base screen was used to identify conditions that suppress this undesired transformation. Building on this, systematic optimization using a Design of Experiments approach delivered mild reaction conditions that were then subsequently applied to a variety of coupling partners.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Safety of 4-Bromo-1-methyl-2-nitro-1H-imidazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole, is researched, Molecular C4H4BrN3O2, CAS is 121816-79-3, about Synthesis and reactions of brominated 2-nitroimidazoles. Author is Palmer, Brian D.; Denny, William A..

Imidazoles reacted with N-bromosuccinimide to give 4-bromo derivatives I (R1 = H, Me, CPh3; R2 = H, NO2, Me). 2-Nitroimidazole gave dibromo compound II as the only product. I (R1 = CPh3, R2 = H) was treated with BuLi, PrONO2, and HCl to give I (R1 = H, R2 = NO2).

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lee, H. H.; Palmer, B. D.; Wilson, W. R.; Denny, W. A. researched the compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole( cas:121816-79-3 ).Category: pyrazines.They published the article 《Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard》 about this compound( cas:121816-79-3 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: chloroethylaminonitroimidazole preparation hypoxia selective cytotoxicity; nitroimidazole mustard preparation hypoxia selective cytotoxicity; imidazole chloroethylaminonitro preparation hypoxia selective cytotoxicity. We’ll tell you more about this compound (cas:121816-79-3).

A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2-nitroimidazole from 1-methyl-2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23862 in UV4 cells (ca. 40-fold), and superior selectivity (>7-fold) in repair-competent AA8 cells.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole(SMILESS: O=[N+](C1=NC(Br)=CN1C)[O-],cas:121816-79-3) is researched.Synthetic Route of C5H5FN2. The article 《Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:121816-79-3).

A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2-nitroimidazole from 1-methyl-2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23862 in UV4 cells (ca. 40-fold), and superior selectivity (>7-fold) in repair-competent AA8 cells.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lee, H. H.; Palmer, B. D.; Wilson, W. R.; Denny, W. A. researched the compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole( cas:121816-79-3 ).SDS of cas: 121816-79-3.They published the article 《Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard》 about this compound( cas:121816-79-3 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: chloroethylaminonitroimidazole preparation hypoxia selective cytotoxicity; nitroimidazole mustard preparation hypoxia selective cytotoxicity; imidazole chloroethylaminonitro preparation hypoxia selective cytotoxicity. We’ll tell you more about this compound (cas:121816-79-3).

A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2-nitroimidazole from 1-methyl-2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23862 in UV4 cells (ca. 40-fold), and superior selectivity (>7-fold) in repair-competent AA8 cells.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Preparation and reactions of bromo-2-nitro- and bromo-2-aminoimidazoles, published in 1993-04-30, which mentions a compound: 121816-79-3, mainly applied to imidazole bromonitro preparation sulfenylation; methylnitroimidazole bromination; reduction methylnitroimidazole; aminobromomethylimidazole debromination; protodebromination aminobromomethylimidazole; nucleophilic substitution bromonitroimidazole, Reference of 4-Bromo-1-methyl-2-nitro-1H-imidazole.

Treatment of 1-methyl-2-nitroimidazole with Br in H2O resulted in rapid dibromination to 4,5-dibromo-1-methyl-2-nitroimidazole. In dioxane, the bromination was slower, but could be controlled to give 4-bromo-1-methyl-2-nitroimidazole (I) and 5-bromo-1-methyl-2-nitroimidazole (II) in a 4:1 ratio. In an attempt to displace the Br, I and II were treated with cysteamine hydrochloride and in each case the nitro group was displaced: I gave only 2-[(2-aminoethyl)thio]-4-bromo-1-methylimidazole, while II gave 2-[(2-aminoethyl)thio]-5-bromo-1-methylimidazole and 2,5-bis[2-(aminoethyl)thio]-1-methylimidazole (III). III may originate from an initial displacement of Br giving 5-[(2-aminoethyl)thio]-1-methyl-2-nitroimidazole, although this could not be observed due to a rapid further displacement of its nitro group. I and II were reduced to their corresponding amines with Zn/HCl and, when refluxed in H2O in the presence or absence of cysteamine hydrochloride, both underwent protodebromination yielding 2-amino-2-methylimidazole. In D2O, 2-amino-4-bromo-1-methylimidazole was converted into 2-amino-4-deuterio-1-methylimidazole. Bromination of 2-amino-1-methylimidazole in H2O resulted in the formation of cis- and trans-2-amino-4,5-dihydro-4,5-dihydroxyimidazolium ions.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of C4H4BrN3O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole, is researched, Molecular C4H4BrN3O2, CAS is 121816-79-3, about Preparation and reactions of bromo-2-nitro- and bromo-2-aminoimidazoles.

Treatment of 1-methyl-2-nitroimidazole with Br in H2O resulted in rapid dibromination to 4,5-dibromo-1-methyl-2-nitroimidazole. In dioxane, the bromination was slower, but could be controlled to give 4-bromo-1-methyl-2-nitroimidazole (I) and 5-bromo-1-methyl-2-nitroimidazole (II) in a 4:1 ratio. In an attempt to displace the Br, I and II were treated with cysteamine hydrochloride and in each case the nitro group was displaced: I gave only 2-[(2-aminoethyl)thio]-4-bromo-1-methylimidazole, while II gave 2-[(2-aminoethyl)thio]-5-bromo-1-methylimidazole and 2,5-bis[2-(aminoethyl)thio]-1-methylimidazole (III). III may originate from an initial displacement of Br giving 5-[(2-aminoethyl)thio]-1-methyl-2-nitroimidazole, although this could not be observed due to a rapid further displacement of its nitro group. I and II were reduced to their corresponding amines with Zn/HCl and, when refluxed in H2O in the presence or absence of cysteamine hydrochloride, both underwent protodebromination yielding 2-amino-2-methylimidazole. In D2O, 2-amino-4-bromo-1-methylimidazole was converted into 2-amino-4-deuterio-1-methylimidazole. Bromination of 2-amino-1-methylimidazole in H2O resulted in the formation of cis- and trans-2-amino-4,5-dihydro-4,5-dihydroxyimidazolium ions.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem