Category: 1215852-11-1

Synthetic Route of 1215852-11-1, A common heterocyclic compound, 1215852-11-1, name is 7-tert-Butyl 3-ethyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-3,7(8H)-dicarboxylate, molecular formula is C13H20N4O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A flask was charged with 7-(t-butyl) 3-ethyl 5,6-dihydro-[l,2,4]triazolo[4,3-a]pyrazine- 3,7(8H)-dicarboxylate (3.00 g, 10.1 mmol, 1.00 equiv), Li OH (1.21 g, 30.3 mmol, 3.00 equiv), EtOH (20 mL) and water (2 mL). The resulting solution was stirred for 2 h at room temperature and concentrated under reduced pressure to provide 2.70 g (crude) of 7-(t-butoxycarbonyl)- 5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3-a]pyrazine-3-carboxylic acid. LCMS (ESI, m/z): 269 [M+H]+

The synthetic route of 1215852-11-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABIDE THERAPEUTICS, INC.; GRICE, Cheryl A.; WEBER, Olivia D.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; JONES, Todd K.; (275 pag.)WO2019/46318; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 1215852-11-1, A common heterocyclic compound, 1215852-11-1, name is 7-tert-Butyl 3-ethyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-3,7(8H)-dicarboxylate, molecular formula is C13H20N4O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: tert-Butyl 3-(2-hydroxypropan-2-yl)-5,6-dihydro-[l,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate. To a solution of 7-tert-butyl 3-ethyl 5,6-dihydro-[l,2,4]triazolo[4,3-a]pyrazine-3,7(8H)-dicarboxylate (0.9 g, 3.04 mmol) in THF (20 mL) at 0C, was added 3 M methylmagnesium iodide in diethyl ether (3.04 mL, 9.11 mmol) dropwise. The reaction was stirred overnight at RT. After 16 hours, the reaction was quenched with saturated aqueous ammonium chloride and extracted with EtOAc. The organic layer was concentrated to provide tert-butyl 3-(2-hydroxypropan-2- yl)-5,6-dihydro-[l,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate as a white powder (0.4 g, 46.6 % yield).

The synthetic route of 1215852-11-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; BODE, Christiane, M.; CHENG, Alan, C.; CHOQUETTE, Deborah; LEWIS, Richard, T.; POTASHMAN, Michele, H.; ROMERO, Karina; STELLWAGEN, John, C.; WHITTINGTON, Douglas, A.; WO2012/18668; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem