Category: 1196151-53-7

Related Products of 1196151-53-7, These common heterocyclic compound, 1196151-53-7, name is 6-Bromopyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 6-bromopyrazine-2-carboxylic acid (404 mg, 1.99 mmol), 2-(4- fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)benzofuran-3-carboxamide (1 g, 1.99 mmol), 2M sodium carbonate (4 ml, 8 mmol), Bis(triphenylphosphine)palladium(II) dichloride (70 mg, 0.1 mmol) was suspended in DME (7 ml), DMF (2 ml), water (3 ml) and EtOH (2 ml) in a sealed tube and heated in a microwave oven at 120C for 20 min.. Then concentrated under vacuum, applied onto Prep HPLC and eluted with H20 (0.1%TFA) and Acetonitrile(0.1%TFA). This resulted in 0.96g (95 %) of 6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N- methylmethylsulfonamido)benzofuran-5-yl)pyrazine-2-carboxylic acid as a white solid. LC-MS (ES, m/z) C23H19FN406S: 498; Found: 499 [M+H]+.

The synthetic route of 1196151-53-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; DAI, Xing; LIU, Hong; HE, Shuwen; LAI, Zhong; DANG, Qung; ZORN, Nicholas; WO2013/34047; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 1196151-53-7, name is 6-Bromopyrazine-2-carboxylic acid, molecular formula is C5H3BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H3BrN2O2

Example 21 Preparation of Compound 297 Step A-Synthesis of Intermediate Compound Int-21a A mixture of 6-bromopyrazine-2-carboxylic acid (404 mg, 1.99 mmol), 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (1 g, 1.99 mmol), 2M sodium carbonate (4 ml, 8 mmol), Bis(triphenylphosphine)palladium(II) dichloride (70 mg, 0.1 mmol) was suspended in DME (7 ml), DMf (2 ml), water (3 ml) and EtOH (2 ml) in a sealed tube and heated in a microwave oven at 120 C. for 20 min. Then concentrated under vacuum, applied onto Prep HPLC and eluted with H2O (0.1% TFA) and Acetonitrile (0.1% TFA). This resulted in 0.96 g (95%) of 6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrazine-2-carboxylic acid as a white solid. LC-MS (ES, m/z) C23H19FN4O6S: 498. Found: 499 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1196151-53-7, its application will become more common.

Reference:
Patent; McComas, Casey Cameron; Liverton, Nigel J.; Habermann, Joerg; Koch, Uwe; Narjes, Frank; Li, Peng; Peng, Xuanjia; Soll, Richard; Wu, Hao; Palani, Anandan; Dai, Xing; Liu, Hong; He, Shuwen; Lai, Zhong; Dang, Qun; Zorn, Nicolas; US2014/199263; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem