Category: 119165-68-3

Application of 119165-68-3,Some common heterocyclic compound, 119165-68-3, name is 2-(1H-Imidazol-2-yl)pyrazine, molecular formula is C7H6N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2: 2-( l -{ [2-(Trimethylsilyl ethoxy1methyl}-l H-imidazol-2-yI)pyrazineTo a solution of 2-(lH-imidazol-2-yl)pyrazine (0.75 g, 5.1 mmol) in DMF (7 mL) was added sodium hydride (60% dispersion in oil, 0.42 g, 10.3 mmol) and the reaction stirred at 40C for 2 hours. [2-(chloromethoxy)ethyl](trimethyl)silane ( 1.71 g, 10.3 mmol) was added and the reaction was stirred at 40C for a further 3 hours The reaction mixture was partitioned between EtOAc and water and the layers separated. The aqueous layers was extracted with EtOAc (x2) and the combined organic layers were dried (MgS04), filtered and concentrated in vacuo. The residue was purified using column chromatography (gradient 20-60% EtOAc in hexane) to give the title compound (0.88 g, yellow oil). NMR (400 MHz, CDC13) delta ppm: 9.47 (d. J=1.0 Hz, 1 H), 8.36 – 8.59 (m, 2 H), 7.26 – 7.28 (m, 1 H), 7.24 (d, J=1.3 Hz, 1 H), 5.96 – 6.00 (m, 2 H), 3.53 – 3.61 (m, 2 H), 0.86 – 0.94 (m, 2 H), -0.10 – -0.05 (m, 9 H).

The synthetic route of 119165-68-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD; DIMOPOULOS, Paschalis; HALL, Adrian; KITA, Yoichi; MADIN, Andrew; SHUKER, Nicola Louise; WO2012/93148; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

119165-68-3, name is 2-(1H-Imidazol-2-yl)pyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 119165-68-3

Step 2: 2-(1-{[2-(Trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrazine To a solution of 2-(4H-imidazol-2-yl)pyrazine (0.75 g, 5.1 mmol) in DMF (7 mL) was added sodium hydride (60% dispersion in oil, 0.42 g, 10.3 mmol) and the reaction stirred at 40 C. for 2 hours. [2-(chloromethoxy)ethyl](trimethyl)silane (1.71 g, 10.3 mmol) was added and the reaction was stirred at 40 C. for a further 3 hours The reaction mixture was partitioned between EtOAc and water and the layers separated. The aqueous layers was extracted with EtOAc (*2) and the combined organic layers were dried (MgSO4), filtered and concentrated in vacuo. The residue was purified using column chromatography (gradient 20-60% EtOAc in hexane) to give the title compound (0.88 g, yellow oil). 1H NMR (400 MHz, CDCl3) delta ppm: 9.47 (d, J=1.0 Hz, 1H), 8.36-8.59 (m, 2H), 7.26-7.28 (m, 1H), 7.24 (d, J=1.3 Hz, 1H), 5.96-6.00 (m, 2H), 3.53-3.61 (m, 2H), 0.86-0.94 (m, 2H), -0.10-0.05 (m, 9H).

The synthetic route of 119165-68-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; Dimopoulos, Paschalis; Hall, Adrian; Kita, Yoichi; Madin, Andrew; Shuker, Nicola Louise; US2014/11802; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 119165-68-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 119165-68-3, name is 2-(1H-Imidazol-2-yl)pyrazine, This compound has unique chemical properties. The synthetic route is as follows.

A methanolic solution containing 0.5 mmol of impz in 5 mL was slowly added to a solution of 0.5 mmol of CuCl2-2H2O in 5 mL of methanol under stirring for 4 h and at room temperature.A green solid precipitated and the powder was collected by filtration, washed with a small amount of cold methanol and dried under vacuum. The yield was 38%. This complex is soluble in water, DMSO and DMF and slightly soluble in methanol and ethanol. Anal. Calc. for CuCl2C7H6N4 (%): C 30.0; H 2.16; N 20.0.Found: C 30.2; H 2.46; N 19.8. Molar conductivity in deionized water (Scm2mol1): 206.9.

The chemical industry reduces the impact on the environment during synthesis 2-(1H-Imidazol-2-yl)pyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Nakahata, Douglas H.; Ribeiro, Marcos A.; Corbi, Pedro P.; Machado, Daisy; Lancellotti, Marcelo; Lustri, Wilton R.; da Costa Ferreira, Ana M.; Formiga, Andre L.B.; Inorganica Chimica Acta; vol. 458; (2017); p. 224 – 232;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem