Category: 118994-89-1

Wang, Xinmou; Chen, Yuming; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published an article about the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1,SMILESS:O=C(C1=CN=CO1)OCC ).Name: Ethyl oxazole-5-carboxylate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:118994-89-1) through the article.

Although compounds with a 2-(2-arylphenyl) benzoxazole motif are biol. important, there are only a few methods for synthesizing them. Herein, authors report an efficient method for synthesis of such compounds by means of cobalt-catalyzed C-H/C-H cross-coupling reactions. This method has a broad substrate scope and good tolerance for sensitive functional groups. In addition, authors demonstrate that introducing a heteroarene moiety to biphenyl compounds enhanced their antifungal activity.

From this literature《Construction of 2-(2-Arylphenyl)azoles via Cobalt-Catalyzed C-H/C-H Cross-Coupling Reactions and Evaluation of Their Antifungal Activity》,we know some information about this compound(118994-89-1)Name: Ethyl oxazole-5-carboxylate, but this is not all information, there are many literatures related to this compound(118994-89-1).

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HPLC of Formula: 118994-89-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Continuous flow as an enabling technology: a fast and versatile entry to functionalized glyoxal derivatives. Author is Lima, Fabio; Meisenbach, Mark; Schenkel, Berthold; Sedelmeier, Joerg.

Two complementary strategies employing organolithium chem. for the synthesis of glyoxal derivatives RC(O)R1R2 (R = methoxymethyl, 3,5-difluorophenyl, pyridin-2-yl, quinolin-6-yl, etc.; R1 = Cl, OEt, H; R2 = Cl, OEt, 3-chlorophenyl) were reported. Micro-mixer technol. allows for the generation of unstable organometallic intermediates and their instantaneous in-line quenching with esters as electrophiles RC(O)OEt. Selective mono-addition was observed via putative stabilized tetrahedral intermediates. Advantages offered by flow chem. technologies facilitate direct and efficient access to masked 1,2-dicarbonyl compounds while mitigating undesired byproduct formation. These two approaches enable the production of advanced and valuable synthetic building blocks for heterocyclic chem. with throughputs of grams per min.

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Yang, Ke; Zhang, Cheng; Wang, Peng; Zhang, Yan; Ge, Haibo published the article 《Nickel-catalyzed decarboxylative acylation of heteroarenes by sp2 C-H functionalization》. Keywords: oxoglyoxylic acid oxazole decarboxylative acylation nickel catalyst; oxazole ketone preparation; acylation; decarboxylation; heteroarenes; nickel; sp2 CH bond functionalization.They researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).Category: pyrazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:118994-89-1) here.

Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids was developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Addnl., this approach provides an efficient access to (ox)azole ketones, an important structural motif in many medicinal compounds with a broad range of biol. activities. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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HPLC of Formula: 118994-89-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Synthetic studies on bengazoles of marine sponge origin. Synthesis of the core bis-oxazole fragments. Author is Chittari, Pabba; Hamada, Yasumasa; Shioiri, Takayuki.

The core bis-oxazole fragment I (R = OCH2OMe, R1 = CHO) was constructed by the coupling of 5-formyloxazole with lithiated 5-(silyoxymethyl)oxazoles, oxidation of the resulting bis(oxazolyl)methanol (II), followed by the asym. reduction with (R)-(+)-BINAL-H as key steps. Addnl., preparation of bis-oxazole fragment I (R = H, R1 = CH2OSiPh2CMe3) was accomplished by the Barton-McCombie radical deoxygenation reaction of II.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ) is researched.Computed Properties of C6H7NO3.Sagud, Ivana; Bozic, Simona; Marinic, Zeljko; Sindler-Kulyk, Marija published the article 《Photochemical approach to functionalized benzobicyclo[3.2.1]octene structures via fused oxazoline derivatives from 4- and 5-(o-vinylstyryl)oxazoles》 about this compound( cas:118994-89-1 ) in Beilstein Journal of Organic Chemistry. Keywords: benzobicyclooctenone preparation; fused oxazoline benzobicyclooctadiene preparation ring opening; cis trans vinylstyryl oxazole preparation intramol photocycloaddition diastereoselective; bicyclo[3.2.1]octane; intramolecular photocycloaddition; oxazole; styryl; vinyl. Let’s learn more about this compound (cas:118994-89-1).

A new photochem. approach for the preparation of functionalized benzobicyclo[3.2.1]octenones was described via fused oxazoline derivatives prepared from 4- and 5-(2-vinylstyryl)oxazoles. Novel cis/trans 4- and 5-(2-vinylstyryl)oxazoles were synthesized by Wittig reactions of o-xylelenebis(triphenylphosphoniumbromide) and formaldehyde with 4- and 5-oxazolecarbaldehydes resp. Trans-5-(2-vinylstyryl)oxazole was also prepared by the van Leusen reaction of trans-3-(2-vinylphenyl)acrylaldehyde which was prepared from o-vinylbenzaldehyde and (formylmethylene)triphenylphosphorane. The photochem. intramol. cycloaddition of cis/trans isomers of 4- and 5-(2-vinylstyryl)oxazoles afforded diverse fused oxazoline-benzobicyclo[3.2.1]octadienes I [stereo = R or S] and II which were relatively unstable. These fused oxazoline-benzobicyclo[3.2.1]octadienes underwent oxazoline ring opening spontaneously or on silica gel followed by formation of benzobicyclo[3.2.1]octenone derivatives III [X = O, stereo = R or S; X = NH, stereo = S]. Small quantity of electrocyclization product 4-(1,2-Dihydronaphthalen-2-yl)oxazole was also isolated along with desired photocycloaddition products on irradiation of 4-(2-vinylstyryl)oxazole.

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Name: Ethyl oxazole-5-carboxylate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions. Author is Vrijdag, Johannes L.; Delgado, Francisca; Alonso, Nerea; De Borggraeve, Wim M.; Perez-Macias, Natalia; Alcazar, Jesus.

A fast and efficient protocol for the formation of amides from low nucleophilic amines and esters in flow is described. Products were obtained in good to excellent yields and with the advantage of simultaneous mixing of all reagents at once, avoiding steps for intermediate formation. The protocol is also suitable to be combined with ester synthesis, giving amides in-line from haloarenes.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl oxazole-5-carboxylate(SMILESS: O=C(C1=CN=CO1)OCC,cas:118994-89-1) is researched.Product Details of 2150-55-2. The article 《Light-Promoted Copper-Catalyzed Enantioselective Alkylation of Azoles》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:118994-89-1).

A catalytic asym. alkylation of azoles with secondary 1-arylalkyl bromides through direct C-H functionalization is reported. Under blue-light photoexcitation, a copper(I)/carbazole-based bisoxazoline (CbzBox) catalytic system exhibits good reactivity and high stereoselectivity, thus offering an efficient strategy for the construction of chiral alkyl azoles. These reactions proceed at low temperature and are compatible with a wide range of azoles.

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Application of 118994-89-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Fluorogenic Behaviour of the Hetero-Diels-Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications. Author is Renault, Kevin; Jouanno, Laurie-Anne; Lizzul-Jurse, Antoine; Renard, Pierre-Yves; Sabot, Cyrille.

Fluorogenic reactions are largely underrepresented in the toolbox of chemoselective ligations despite their tremendous potential, particularly in chem. biol. and biochem. In this respect, we have investigated in full detail the fluorescence behavior of the azaphthalamide, a scaffold which is generated through a hetero-Diels-Alder reaction of 5-alkoxyoxazole and maleimide derivatives under mild conditions that are compatible with, among others, peptide chem. The scope and limitations of such a fluorogenic labeling strategy were examined through four distinct applications, which target enzymic activities or bioorthogonal reactions.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Continuous flow as an enabling technology: a fast and versatile entry to functionalized glyoxal derivatives, published in 2021, which mentions a compound: 118994-89-1, mainly applied to glyoxal preparation; dichloromethane ester condensation continuous flow; ethyl diethoxyacetate aryl bromide condensation continuous flow; bromochlorobenzene ester condensation continuous flow, Name: Ethyl oxazole-5-carboxylate.

Two complementary strategies employing organolithium chem. for the synthesis of glyoxal derivatives RC(O)R1R2 (R = methoxymethyl, 3,5-difluorophenyl, pyridin-2-yl, quinolin-6-yl, etc.; R1 = Cl, OEt, H; R2 = Cl, OEt, 3-chlorophenyl) were reported. Micro-mixer technol. allows for the generation of unstable organometallic intermediates and their instantaneous in-line quenching with esters as electrophiles RC(O)OEt. Selective mono-addition was observed via putative stabilized tetrahedral intermediates. Advantages offered by flow chem. technologies facilitate direct and efficient access to masked 1,2-dicarbonyl compounds while mitigating undesired byproduct formation. These two approaches enable the production of advanced and valuable synthetic building blocks for heterocyclic chem. with throughputs of grams per min.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lassalas, Pierrik; Marsais, Francis; Hoarau, Christophe researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).Product Details of 118994-89-1.They published the article 《DMAP-catalyzed Regel-type direct C-2 (hetero)aroylation of oxazoles and thiazoles derivatives with acid chlorides》 about this compound( cas:118994-89-1 ) in Synlett. Keywords: aroyl substituted oxazole thiazole preparation; oxazole thiazole acyl chloride aroylation DMAP catalyst. We’ll tell you more about this compound (cas:118994-89-1).

A Regel-type transition-metal-free direct C-2 aroylation of (benzo)oxazoles, (benzo)thiazoles and 1,3,4-oxadiazoles with acid chlorides catalyzed by N,N-dimethyl-4-aminopyridine (DMAP) is described. This methodol. is effective with several aroyl and heteroaroyl chlorides affording the corresponding 2-ketoazoles in moderate to excellent yields.

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