Category: 118994-89-1

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Synthesis and evaluation of anthelmintic and cytotoxic properties of [2,5′]bis-1,3-azole analogs of bengazoles, the main research direction is bisazole derivative preparation anthelmintic cytotoxicity.Application In Synthesis of Ethyl oxazole-5-carboxylate.

Using different heterocycle formation methodologies (Deoxo-Fluor, DAST, POCl3, TosMIC), [2,5′]bis-1,3-azoles were prepared as stable analogs of bengazoles, a family of potent anthelmintic marine natural products. The cytotoxic activity of these heterocycles and their precursors on HCT-15 cells and the effect on the L4 larvae of Nippostrongylus brasiliensis were evaluated.

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Pyrazine – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ) is researched.Quality Control of Ethyl oxazole-5-carboxylate.Vedejs, Edwin; Luchetta, Leza M. published the article 《A Method for Iodination of Oxazoles at C-4 via 2-Lithiooxazoles》 about this compound( cas:118994-89-1 ) in Journal of Organic Chemistry. Keywords: iodination lithiation oxazole; coupling iodination lithiation oxazole. Let’s learn more about this compound (cas:118994-89-1).

Lithiation and sequential iodination of oxazole derivatives gave mixtures of 4-iodooxazole derivatives, 2-iodooxazole derivatives and 2,4-diiodooxazole derivatives Metalation of 5-(4-methylphenyl)oxazole and coupling with 4-iodo-5-(2-phenylethyl)oxazole gave the resp. 2,4′-bisoxazole.

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Pyrazine – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl oxazole-5-carboxylate(SMILESS: O=C(C1=CN=CO1)OCC,cas:118994-89-1) is researched.Quality Control of 2-Chloro-5-iodo-3-methylpyridine. The article 《Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:118994-89-1).

Herein, the discovery of reldesemtiv I, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit, 4-(4-fluorobenzyl)-5-(phenethylamino)-1,2,4-thiadiazole, led to compounds with improved free exposure and in vivo muscle activation potency compared to the first-generation FSTA, tirasemtiv. The compound I demonstrated increased muscle force generation in a phase 1 clin. trial and is currently being evaluated in clin. trials for the treatment of amyotrophic lateral sclerosis.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about DMAP-catalyzed Regel-type direct C-2 (hetero)aroylation of oxazoles and thiazoles derivatives with acid chlorides, the main research direction is aroyl substituted oxazole thiazole preparation; oxazole thiazole acyl chloride aroylation DMAP catalyst.Computed Properties of C6H7NO3.

A Regel-type transition-metal-free direct C-2 aroylation of (benzo)oxazoles, (benzo)thiazoles and 1,3,4-oxadiazoles with acid chlorides catalyzed by N,N-dimethyl-4-aminopyridine (DMAP) is described. This methodol. is effective with several aroyl and heteroaroyl chlorides affording the corresponding 2-ketoazoles in moderate to excellent yields.

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Application of 118994-89-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Copper-catalyzed diarylation of Se with aryl iodides and heterocycles. Author is Hu, Dehua; Liu, Miaochang; Wu, Huayue; Gao, Wenxia; Wu, Ge.

The regioselective copper-catalyzed three-component coupling reaction of electron-deficient heterocycles, like aryl-oxadiazoles/aryloxazoles/dimethyl-purine-diones, etc. with aryl iodides in presence of Se powder so as to yield corresponding diaryl-selenated heterocycles such as arylselanyl-aryl-oxadiazoles I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = Ph, 2-naphthyl, 3-thienyl, etc.] and arylselanyl-aryl-oxazoles II [R2 = Ph, 2,4,6-triMeC6H2; R3 = CO2Et, Ph, 4-MeSC6H4, etc.] was disclosed. The established methodol. provided an efficient and practical pathway to access arylselenated heterocycles via copper-catalyzed double C-Se bond formation. This transformation featured the use of elemental Se as the selenating reagent, a cost-effective catalytic system and the late-stage selenation of bioactive compounds

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Xing, Qi; Lv, Hui; Xia, Chungu; Li, Fuwei researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).Reference of Ethyl oxazole-5-carboxylate.They published the article 《Palladium-catalyzed intermolecular carbonylative cross-coupling of heteroaryl C(sp2)-H bonds with amines: an efficient strategy for oxidative aminocarbonylation of azoles》 about this compound( cas:118994-89-1 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: heteroarylamide preparation green chem; azole amine intermol oxidative aminocarbonylation palladium catalyst. We’ll tell you more about this compound (cas:118994-89-1).

An efficient palladium-catalyzed oxidative aminocarbonylation of azoles such as benzothiazole, 5-chloro benzoxazole, 4,5-dimethyl-1,3-thiazole, etc. has been developed. This system allows for intermol. carbonylative cross-coupling of aromatic C(sp2)-H bonds with simple amines RR1NH [R = H, CH2CH3, c-C6H11, etc.; R1 = C(H3)3, (CH2)2CH3, CH2C6H5, etc.; RR1 = -(CH2)2O(CH2)2-, -(CH2)5-], which has often been asked for, but has not been realized so far. It provides a straightforward approach to a variety of azol-2-amides RR1NC(O)R2 (R2 = 1,3-benzothiazol-2-yl, 5-chloro-1,3-benzoxazol-2-yl, dimethyl-1,3-thiazol-2-yl, etc.).

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Reference:
Pyrazine – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Highly Enantioselective Mukaiyama Aldol Reactions Catalyzed by a Chiral Oxazaborolidinium Ion: Total Synthesis of (-)-Inthomycin C, published in 2010-11-19, which mentions a compound: 118994-89-1, Name is Ethyl oxazole-5-carboxylate, Molecular C6H7NO3, HPLC of Formula: 118994-89-1.

A cationic oxazaborolidinium-catalyzed asym. Mukaiyama aldol reaction of (1-methoxy-2-methyl-propenyloxy)-trimethylsilane with various aldehydes including α,β-disubstituted acroleins has been developed in high yields and enantioselectivities. The synthetic utility of this methodol. was demonstrated in the first short synthesis of naturally occurring inthomycin C (I) in high enantio-purity.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A Two-Stage Iterative Process for the Synthesis of Poly-oxazoles, published in 2005-07-21, which mentions a compound: 118994-89-1, mainly applied to oxazole oligomer preparation, HPLC of Formula: 118994-89-1.

Methodol. has been developed to prepare bis-oxazoles via a two-stage iterative process. The sequence begins with C(2)-chlorination of a lithiated oxazole using hexachloroethane. Generation of the C(2)-C(4′) bond by SNAr substitution with TosMIC anion, followed by conversion to the heterocycle in a one-pot reaction with glyoxylic acid monohydrate, affords the desired bis-oxazole in good yield and purity. The two-stage process allows for efficient synthesis of a tris-oxazole and the iterative preparation of a tetra-oxazole.

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Pyrazine – Wikipedia,
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Related Products of 118994-89-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Nickel-Catalyzed Decarboxylative Arylation of Heteroarenes through sp2 C-H Functionalization.

The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel-catalyzed sp2 C-H functionalization process was developed. This process provides the first examples of decarboxylative cross-coupling reactions with aromatic acids through nickel catalysis and tolerates a variety of functional groups. Moreover, this method provides efficient access to 2-aryl-substituted azoles, an important structural unit in natural products, medicinal compounds, and functional materials.

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Pyrazine – Wikipedia,
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Category: pyrazines. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about The Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines. Author is Lehmann, Johannes; Alzieu, Thibaut; Martin, Rainer E.; Britton, Robert.

A continuous flow inverse-electron-demand Kondrat’eva reaction has been developed that provides direct access to cycloalka[c]pyridines from unactivated oxazoles and cycloalkenes. The cycloadditions of both unactivated alkenes and deactivated oxazoles are promoted in continuous flow at elevated temperatures and pressures (230 °C, 750psi). E.g., reaction of 5-phenyloxazole and cyclopentene in presence of TFA gave 55% 4-phenyl-6,7-dihydro-5H-cyclopenta[c]pyridine (I). Annulated pyridines obtained by this one-step process are valuable scaffolds for medicinal chem.

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Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem