Category: 118994-89-1

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 118994-89-1, is researched, SMILESS is O=C(C1=CN=CO1)OCC, Molecular C6H7NO3Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Direct arylation of oxazoles at C2. a concise approach to consecutively linked oxazoles, Author is Flegeau, Emmanuel Ferrer; Popkin, Matthew E.; Greaney, Michael F., the main research direction is substituted oxazole derivative preparation; oxazole aryl iodide cross coupling palladium; teroxazolecarboxylate preparation.COA of Formula: C6H7NO3.

The synthesis of bis- and trisoxazoles via direct arylation is discussed. A variety of aryl groups can be installed at the 2-position of 5-aryl and 5-carboxy-substituted oxazoles under mild conditions using palladium catalysis on water. The direct arylation method can be extended to the synthesis of bis- and trisoxazoles if 2-triisopropylsilyl-4-iodooxazole is used as the electrophile in the arylation.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Palladium-catalyzed direct C2-arylation of azoles with aromatic triazenes, published in 2019, which mentions a compound: 118994-89-1, Name is Ethyl oxazole-5-carboxylate, Molecular C6H7NO3, Application of 118994-89-1.

A highly efficient palladium-catalyzed arylation of azoles at the C2-position using 1-aryltriazenes as aryl reagents was developed for the synthesis of aryl azoles, e.g., I. Azoles including oxazoles, thiazoles, imidazoles, 1,3,4-oxadiazoles and oxazolines reacted with 1-aryltriazenes smoothly to generate the corresponding products in good to excellent yields and various substitution patterns were tolerated toward the reaction.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Name: Ethyl oxazole-5-carboxylate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Copper-catalyzed diarylation of Se with aryl iodides and heterocycles. Author is Hu, Dehua; Liu, Miaochang; Wu, Huayue; Gao, Wenxia; Wu, Ge.

The regioselective copper-catalyzed three-component coupling reaction of electron-deficient heterocycles, like aryl-oxadiazoles/aryloxazoles/dimethyl-purine-diones, etc. with aryl iodides in presence of Se powder so as to yield corresponding diaryl-selenated heterocycles such as arylselanyl-aryl-oxadiazoles I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = Ph, 2-naphthyl, 3-thienyl, etc.] and arylselanyl-aryl-oxazoles II [R2 = Ph, 2,4,6-triMeC6H2; R3 = CO2Et, Ph, 4-MeSC6H4, etc.] was disclosed. The established methodol. provided an efficient and practical pathway to access arylselenated heterocycles via copper-catalyzed double C-Se bond formation. This transformation featured the use of elemental Se as the selenating reagent, a cost-effective catalytic system and the late-stage selenation of bioactive compounds

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Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A Two-Stage Iterative Process for the Synthesis of Poly-oxazoles, published in 2005-07-21, which mentions a compound: 118994-89-1, mainly applied to oxazole oligomer preparation, COA of Formula: C6H7NO3.

Methodol. has been developed to prepare bis-oxazoles via a two-stage iterative process. The sequence begins with C(2)-chlorination of a lithiated oxazole using hexachloroethane. Generation of the C(2)-C(4′) bond by SNAr substitution with TosMIC anion, followed by conversion to the heterocycle in a one-pot reaction with glyoxylic acid monohydrate, affords the desired bis-oxazole in good yield and purity. The two-stage process allows for efficient synthesis of a tris-oxazole and the iterative preparation of a tetra-oxazole.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Development of Flexible and Scalable Routes to Two Phosphatidinylinositol-3-kinase Delta Inhibitors via a Common Intermediate Approach, published in 2018-03-16, which mentions a compound: 118994-89-1, Name is Ethyl oxazole-5-carboxylate, Molecular C6H7NO3, COA of Formula: C6H7NO3.

This paper describes the discovery and development of a flexible route to two candidate drug mols. by a common intermediate approach. Key reactions include Negishi and Suzuki couplings to form biaryl bonds. Conditions for a Miyaura borylation of heteroaryl bromides were also developed. Heteroaryl trifluoroborates and aryl chlorides were used as coupling partners in the Suzuki reaction, thereby minimizing detrimental side reactions such as protodeboronation and oxidative homocoupling. A complementary set of reaction conditions using pinacolboronates with potassium bifluoride as an additive were also developed and used to make 5 kg of drug substance for use in early-phase clin. trials.

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Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recommanded Product: 118994-89-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions. Author is Vrijdag, Johannes L.; Delgado, Francisca; Alonso, Nerea; De Borggraeve, Wim M.; Perez-Macias, Natalia; Alcazar, Jesus.

A fast and efficient protocol for the formation of amides from low nucleophilic amines and esters in flow is described. Products were obtained in good to excellent yields and with the advantage of simultaneous mixing of all reagents at once, avoiding steps for intermediate formation. The protocol is also suitable to be combined with ester synthesis, giving amides in-line from haloarenes.

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Pyrazine – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ) is researched.Formula: C6H7NO3.Webb, Michael R.; Addie, Matthew S.; Crawforth, Catherine M.; Dale, James W.; Franci, Xavier; Pizzonero, Mathieu; Donald, Craig; Taylor, Richard J. K. published the article 《The syntheses of rac-inthomycin A, (+)-inthomycin B and (+)-inthomycin C using a unified synthetic approach》 about this compound( cas:118994-89-1 ) in Tetrahedron. Keywords: asym synthesis inthomycin B C Mukaiyama aldol reaction; Stille coupling reaction asym synthesis inthomycin A B C. Let’s learn more about this compound (cas:118994-89-1).

The Stille coupling between a common oxazole vinyl iodide and stereodefined stannyl-diene units is described as the cornerstone of a unified synthetic route to the inthomycin family of bioactive Streptomyces metabolites. This procedure has been utilized to prepare (+)-inthomycin B (I) and (+)-inthomycin C (II) for the first time; in these examples the stereogenic center was introduced using the Kiyooka ketene acetal/amino acid-derived oxazaborolidinone variant of the Mukaiyama aldol reaction. In addition, a convenient preparation of rac-inthomycin A (III) is described based on the same strategy.

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Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recommanded Product: Ethyl oxazole-5-carboxylate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Direct C2-Heteroarylation of Indoles by Rhodium-Catalyzed C-C Bond Cleavage of Secondary Alcohols. Author is Yu, Tian-Yang; Zheng, Zhao-Jing; Sun, Wei; Qiao, Zi-Heng.

A rhodium-catalyzed direct heteroarylation of indoles by cleavage of an inert C-C bond of alcs. is reported. This catalytic system exhibits high reactivity and tolerates various functional groups. This reaction provides a tool for the rapid construction of biheteroaryls without pre-activation of the starting materials. Control experiments were conducted to determine a possible mechanism. This reaction makes a significant contribution to the field of C-C bond activation of alcs.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chittari, Pabba; Hamada, Yasumasa; Shioiri, Takayuki researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).Safety of Ethyl oxazole-5-carboxylate.They published the article 《Synthetic studies on bengazoles of marine sponge origin. Synthesis of the core bis-oxazole fragments》 about this compound( cas:118994-89-1 ) in Synlett. Keywords: bisoxazole bengazole core preparation; oxazole bengazole core preparation. We’ll tell you more about this compound (cas:118994-89-1).

The core bis-oxazole fragment I (R = OCH2OMe, R1 = CHO) was constructed by the coupling of 5-formyloxazole with lithiated 5-(silyoxymethyl)oxazoles, oxidation of the resulting bis(oxazolyl)methanol (II), followed by the asym. reduction with (R)-(+)-BINAL-H as key steps. Addnl., preparation of bis-oxazole fragment I (R = H, R1 = CH2OSiPh2CMe3) was accomplished by the Barton-McCombie radical deoxygenation reaction of II.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 118994-89-1, is researched, Molecular C6H7NO3, about Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120, the main research direction is phenyl pyrrole carboxamide preparation antiviral ADMET HIV1 gp120 structure; ADMET; Broad spectrum; ENV-pseudovirus; HIV-1; Structure-activity relationship (SAR); Virus entry antagonist; “CH(2)OH” switch hypothesis.Safety of Ethyl oxazole-5-carboxylate.

The authors are continuing the concerted effort to optimize the first lead entry antagonist, NBD-11021, which targets the Phe 43 cavity of the HIV-1 envelope glycoprotein gp120, to improve antiviral potency and ADMET properties. The authors present a structure-based approach that helped to generate working hypotheses to modify further a recently reported advanced lead entry antagonist, NBD-14107, which showed significant improvement in antiviral potency when tested in a single-cycle assay against a large panel of Env-pseudotyped viruses. The authors report the synthesis of twenty-nine new compounds and evaluation of their antiviral activity in a single-cycle and multi-cycle assay to derive a comprehensive structure-activity relationship (SAR). The authors have selected three inhibitors with the high selectivity index for testing against a large panel of 55 Env-pseudotyped viruses representing a diverse set of clin. isolates of different subtypes. The antiviral activity of one of these potent inhibitors, 55 (NBD-14189), against some clin. isolates was as low as 63 nM. The authors determined the sensitivity of CD4-binding site mutated-pseudoviruses to these inhibitors to confirm that they target HIV-1 gp120. Furthermore, the authors assessed their ADMET properties and compared them to the clin. candidate attachment inhibitor, BMS-626529. The ADMET data indicate that some of these new inhibitors have comparable ADMET properties to BMS-626529 and can be optimized further to potential clin. candidates.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem