Category: 118853-60-4

Related Products of 118853-60-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118853-60-4 as follows.

Into a 50-mL round-bottom flask was placed pyridine (25 mL), methyl 6- aminopyrazine-2-carboxylate (1 g, 6.53 mmol, 1.00 equiv) and 1-methyl-1H-pyrazole-4- carbonyl chloride (1.13 g, 7.82 mmol, 1.20 equiv). The resulting solution was stirred for 2 h at 25 oC in an oil bath. The resulting mixture was concentrated under vacuum at 55 oC for 1 h. This resulted in 1.72 g (93% purity) of methyl 6-(1-methyl-1H-pyrazole-4-amido)pyrazine-2- carboxylate as a yellow solid.

According to the analysis of related databases, 118853-60-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LYCERA CORPORATION; AICHER, Thomas, Daniel; PADILLA, Fernando; TOOGOOD, Peter, L.; CHEN, Shoujun; (331 pag.)WO2016/138335; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 118853-60-4, name is Methyl 6-aminopyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 6-aminopyrazine-2-carboxylate

A solution of methyl 6-amino-2-pyrazinecarboxylate (17 kg, 111 mmol, 1.00 equiv) in N,N-dimethylformamide (100 L) was placed in a 200 L reactor. NBromosuccinimide (56 kg, 333 mol, 3.3 equiv) was added in several portions to above thesolution while maintaining the temperature at 0C. The reaction progress was monitored by TLC (EA: PE = 1: 1) until the starting material was consumed completely. The reaction was quenched with 300 L water/ice. The solids were collected by filtration and dried. The crude product was re-crystallized in a solvent of MeOH (Svol: 1 g). The product (17 kg, purity = 98 %, 54%) was obtained as a yellow solid.1H-NIVIR (300 MHz, DMSO-d6) : 7.36(2H, b), 3.87(3H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CUI, Haifeng; HENNESSY, Alan; JIN, Qi; MILES, Timothy James; MOSS, Stephen Frederick; PEARSON, Neil David; (173 pag.)WO2017/29602; (2017); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 118853-60-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118853-60-4 as follows.

Into a 50-mL round-bottom flask was placed pyridine (25 mL), methyl 6- aminopyrazine-2-carboxylate (1 g, 6.53 mmol, 1.00 equiv) and 1-methyl-1H-pyrazole-4- carbonyl chloride (1.13 g, 7.82 mmol, 1.20 equiv). The resulting solution was stirred for 2 h at 25 oC in an oil bath. The resulting mixture was concentrated under vacuum at 55 oC for 1 h. This resulted in 1.72 g (93% purity) of methyl 6-(1-methyl-1H-pyrazole-4-amido)pyrazine-2- carboxylate as a yellow solid.

According to the analysis of related databases, 118853-60-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LYCERA CORPORATION; AICHER, Thomas, Daniel; PADILLA, Fernando; TOOGOOD, Peter, L.; CHEN, Shoujun; (331 pag.)WO2016/138335; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem