117719-17-2 Archives

Sep-21 News Extracurricular laboratory: Synthetic route of 117719-17-2

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Bromo-3-morpholinopyrazin-2-amine

5-bromo-3-morpholin-4-yl-pyrazin-2-ylamine (300 mg, 1 eq) was suspended in EtOH (3 mL) and 2,3-dibromo-n-methylmaleimide (31 1 mg, 1 eq) was added. The reaction mixture was heated under microwave irradiation at 120 C for 4 h. On cooling, the mixture was filtered to give a yellow solid (50 mg,) which was heated at 150 C for 5 min under open air. On cooling, the mixture was purified by automated chromatography (Biotage, eluent: 2% to 10% MeOH in DCM) to obtain the expected product I-20 (22 mg) as a yellow solid.

Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONC&Oacgr;LOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ ARISTEGUI, Sonsoles; GONZALES CANTALAPIEDRA, Esther; HERNANDEZ HIGUERAS, Ana Isabel; VARELA BUSTO, Carmen; WO2011/36461; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

9/10/2021 News The important role of 117719-17-2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 117719-17-2.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H11BrN4O

A mixture of intermediate 1-02 (360 mg, 1.35 mmol), indazole-4-boronic acid hydrochloride (600 mg, 2.97mmol), K2C03 (2 mE of saturated solution), PdC12(dppf). DCM (112 mg, 0.135 mmol) in DME (5 mE) was heatedunder microwave irradiation for 10 mm at 130 C. Thereaction mixture was filtered through a celite pad, washingwith DCM. The filtrate was dried over Na2SO4 and concentrated. The crude was purified by flash column chromatography (Isolute Si 1110 g cartridge) eluting with a gradient ofDCMJMeOH (from 100% to 90:10) to yield 250 mg of theintermediate 1-03 pure (Y: 62%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 117719-17-2.

Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); Serrano Marugan, Manuel; Pastor Fernandez, Joaquin; Martinez Gonzalez, Sonia; Ortega Molina, Ana; Bischoff, James R.; Oyarzabal Santamarina, Julen; (220 pag.)US9993554; (2018); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Brief introduction of C8H11BrN4O

The synthetic route of 117719-17-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. name: 5-Bromo-3-morpholinopyrazin-2-amine

5-bromo-3-morpholin-4-yl-pyrazin-2-ylamine (5 g, 1 eq) was suspended in DME (30 mL) and dimethyl 3-bromo-2-oxopentanedioate (7.33 g, 1 .5 eq) was added. The reaction mixture was heated in a sealed tube at 90C for 27 h and then at 70 C for 48 h. On cooling, the reaction mixture was filtered to give the expected product. This solid was dissolved in DCM (150 mL) and washed with HCI 2N (2 x 100 mL). The organic layer was dried, (Na2S04), filtered and evaporated to give the expected product (1.9 g, 24% yield) as a beige solid. The filtrate of the reaction mixture was evaporated and the residue was purified by column chromatography (Biotage, eluent: 20% to 50% EtOAc in Cyclohexane) to give the expected product intermediate 1-18, (0.77 g, 10% yield) as an orange solid

The synthetic route of 117719-17-2 has been constantly updated, and we look forward to future research findings.

Extended knowledge of 5-Bromo-3-morpholinopyrazin-2-amine

The synthetic route of 117719-17-2 has been constantly updated, and we look forward to future research findings.

117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 5-Bromo-3-morpholinopyrazin-2-amine

Chloroacetaldehyde (4.4 g) was mixed with isopropanol (15 mL) and a portion of the mixture (10 mL) was added to a round bottom flask containing compound 2 (1.7 g). Then the temperature was raised to 45 C and stirring was continued. After 1 h, the remaining solution was added and thetemperature raised to 65 C with continuous stirring. After TLC indicated the reaction was finished, the reaction was stopped and cooled to room temperature. Then the solution was added into a beaker containing ice water (300 mL) with continuous stirring. The brown-yellow solid that precipitated was filtered and dried to give the product in a yield of 26.8%. 1H-NMR (DMSO-d6) delta 7.93 (s, 1H),7.25 (d, J = 7.3 Hz, 1H), 7.01 (d, J = 7.3 Hz, 1H), 3.45 (s, 4H), 3.77 (d, J = 4.3 Hz, 4H).

The synthetic route of 117719-17-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xu, Shan; Sun, Chengyu; Chen, Chen; Zheng, Pengwu; Zhou, Yong; Zhou, Hongying; Zhu, Wufu; Molecules; vol. 22; 2; (2017);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Continuously updated synthesis method about 117719-17-2

A mixture of 5-bromo-3-morpholinopyrazin-2-amine (150 mg, 0.70 mmol, 1 eq) and ethyl 3-bromo-4-oxocyclohexanecarboxylate (210 mg, 0.84 mmol, 1.2 eq) in dioxane (1.0 mL) was heated for 18 h at 120C in a sealed tube. Two more batches were progressed. The crude mixtures from different batches were combined and the residue was purified by column chromatography (EtOAc as eluent) to give a brown oil that was repurified by column chromatography (hexanes/EtOAc 10:1) to give intermediate I-05 as a yellow solid (42 mg, 6% combined yield).

Extracurricular laboratory: Synthetic route of 117719-17-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 117719-17-2, its application will become more common.

Some common heterocyclic compound, 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, molecular formula is C8H11BrN4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 5-Bromo-3-morpholinopyrazin-2-amine

To a solution of Intermediate 1-02 (150 mg, 0.58 mmol) in Toluene (6.8 mE), 2-chloro-1,1-dimethoxypropane (0.758mE, 5.8 mmol) and p-toluenesulfonic acid (18 mg, 0.09 mmol) were added. The reaction mixture was refluxed for 24 hand additional amounts of 2-chloro-1 , 1-dimethoxypropane (10 eq) and p-toluenesulfonic acid (0.16 eq) were added. The reaction mixture was refluxed for 15 h and the solvent was removed. The residue was purified by column chromatography (Isolute 10 g; AcOEt-cyclohexane 0:100 to 50:50) to give the Intermediate 1-70 (55 mg, 32%) as a beige solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 117719-17-2, its application will become more common.

Some scientific research about C8H11BrN4O

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-3-morpholinopyrazin-2-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 117719-17-2, Recommanded Product: 5-Bromo-3-morpholinopyrazin-2-amine

A mixture of 5-bromo-3-morpholin-4-yl-pyrazin-2-ylamine (0.3 g, 1 eq), methyl 4- oxobutanoate (182 mu, 1.5 eq), 1 , 1 ,3,3-tetramethylbutyl isocyanide (305 mu, 1 .5 eq) and ZrCL, (54 mg, 0.2 eq) in PEG-400 (3 mL) was heated at 50 C under open air for 20 h and 24 h more. On cooling, H20 (60 mL) was added and the mixture was extracted with EtOAc (3 x 50 mL). The organics were dried, filtered and evaporated and the residue was purified by automated chromatography (Biotage, eluent: 20% to 40% EtOAc in Cyclohexane) to give the expected product 1-14 (155 mg, 26% yield) as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-3-morpholinopyrazin-2-amine, and friends who are interested can also refer to it.

New learning discoveries about 117719-17-2

The synthetic route of 117719-17-2 has been constantly updated, and we look forward to future research findings.

A mixture of Intermediate 1-02 (8.17 g, 31.52 mmol) and 1,3-dichloroacetone (6.0 g, 47.29 mmol) in 2-propanol (15 mE) was heated in a sealed tube at 55 C. for 2 days. Oncooling, the mixture was filtered and rinsed with Et20 and MeOR. The solid was purified by flash chromatography on silica gel (MeOH:DCM, 5:95) and the product obtained was washed with MeOR and dried to give Intermediate 1-57(3.97 g, 38%).

The synthetic route of 117719-17-2 has been constantly updated, and we look forward to future research findings.

Brief introduction of C8H11BrN4O

The synthetic route of 5-Bromo-3-morpholinopyrazin-2-amine has been constantly updated, and we look forward to future research findings.

Application of 117719-17-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Preparation of Intermediate I-28. Intermediate I-02 (1.2 g, 4.7 mmol) and ethyl 2-chloroacetoacetate (2.3 g, 14.2 mmol) were suspended in EtOH (12 mL). The mixture was heated under microwave irradiation for 1 h at 150 C. After cooling down to room temperature, petroleum ether was added and the solid formed was filtered off. The filtrate was evaporated under reduced pressure and the residue was purified by flash chromatography on silica gel (c-Hex/EtAOAc 8:2) to obtain a solid that was washed with petroleum ether to give the desired product I-28 (231 mg, Y: 33%).

The synthetic route of 5-Bromo-3-morpholinopyrazin-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Centro Nacional De Investigaciones Oncologicas (CNIO); US2012/83492; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Share a compound : C8H11BrN4O

According to the analysis of related databases, 117719-17-2, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 117719-17-2 as follows. Formula: C8H11BrN4O

Preparation of Intermediate I-57. A mixture of Intermediate I-02 (8.17 g, 31.52 mmol) and 1,3-dichloroacetone (6.0 g, 47.29 mmol) in 2-propanol (15 mL) was heated in a sealed tube at 55 C. for 2 days. On cooling, the mixture was filtered and rinsed with Et2O and MeOH. The solid was purified by flash chromatography on silica gel (MeOH:DCM, 5:95) and the product obtained was washed with MeOH and dried to give Intermediate I-57 (3.97 g, 38%).

According to the analysis of related databases, 117719-17-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Centro Nacional De Investigaciones Oncologicas (CNIO); US2012/83492; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem