Synthetic Route of 111454-68-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 111454-68-3, name is 5-Bromo-2,3-dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: 1-cyano-4-chlorobenzene (13.8 g, 0.1 mol), 2-methyl-5-aminopyridine (10.8 g, 0.1 mol), palladium acetate (0.08 g, 0.32 mmol), 2,2′-bis ( Diphenylphosphino)-1-1′-binaphthyl (0.26 g, 0.42 mmol), sodium tertiary butoxide (15.2 g, 0.16 mol) was added to 150 mL of toluene and refluxed for 12 hours. After cooling to room temperature, washed with methanol and recrystallized from dichloromethane and methanol to obtain [Intermediate 1-a] 15.3 g (yield 73%).
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2,3-dimethylpyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SFC Ltd.; Oh Hyeong-yun; Choi Yeong-tae; Yoon Su-gyeong; Kim Tae-il; (49 pag.)KR102080738; (2020); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem