Category: 109838-85-9

Some common heterocyclic compound, 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, molecular formula is C9H16N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Step C – Synthesis of Intermediate Compound Int-7cTo a solution of (i?)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (6.16 g, 33.4 mmol) in THF (60 mL) was added TBAI (617 mg, 1.67 mmol). The mixture was cooled to -78 °C and a solution of rc-BuLi (14.7 mL, 2.5M in hexanes, 36.75 mmol) was slowly added over 10 minutes. The reaction mixture was allowed to stir at -78 °C for 30 minutes, then Int-7b in THF (20 mL) was slowly added over 10 minutes. The reaction was allowed to stir at -78 °C for 2 hours then allowed to warmed to room temperature and allowed to stir for about 15 hours. The reaction was quenched by addition of MeOH (5 mL), concentrated in vacuo, water added (50 mL) followed by diethyl ether (50 mL) and the layers were separated. The organic layer was washed with water (2 x 50 mL) then dried over Na2S04, filtered and concentrated in vacuo to provide the crude product. Further purification by column chromatograpy on a 330 g ISCO Redi-Sep silica gel column using a eluent of CH2C12 with a gradient of 0-10percent EtOAc/hexanes afforded the desired product Int-7c as a light amber oil (8.65 g, 63percent). 1H NMR (CDC13) ? 4.07-3.99 (m, 1H), 3.94- 3.89 (m, 1H), 3.79-3.71 (m, 2H), 3.68-3.63 (m, 6H), 2.32-2.17 (m, 1H), 1.25-1.21 (m, 1H), 1.06-0.95 (m, 5H), 0.88 (s, 10H), 0.74-0.68 (m, 1H), 0.69-0.66 (m, 2H), 0.12-0.02 (m, 12H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109838-85-9, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DWYER, Michael, P.; KEERTIKAR, Kartik, M.; ZENG, Qingbei; MAZZOLA, Robert, D., Jr.; YU, Wensheng; TANG, Haiqun; KIM, Seong Heon; TONG, Ling; ROSENBLUM, Stuart, B.; KOZLOWSKI, Joseph, A.; NAIR, Anilkumar Gopinadhan; WO2013/39876; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 109838-85-9,Some common heterocyclic compound, 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, molecular formula is C9H16N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1; (2S)-2- (fert-butoxycarbonyl) aminol-3-cLrcloheptylpropanoic acid building block; a) Methyl (2S)-2-amino-3-cycloheptylpropanoate; To a stirred solution of R-2,5-dihydro-3, 6-dimethoxy-2-isopropyl pyrazine (5 g, 27 mmol) in THF (80 mL) at-78 °C was added dropwise 2.5 M n-butyllithium in hexanes over 40 min, maintaining the temperature of the reaction mixture below-70 °C. To the reaction mixture was added dropwise a solution of iodomethylcycloheptane (Webb et al, J. Med. Chem. , 42,8 (1999), 1415-1421. ) (6.8 g, 28. 5 mmol) in THF (12 mL) over 50 min, maintaining the temperature of the reaction mixture below-70 °C. The reaction mixture was then stirred at 0 °C for another 75 min, acetic acid was added (2.45 mL) and stirring was continued for another 20 min. The reaction mixture was then diluted with ethyl acetate (200 mLI), washed with brine (2 x 50 mLI), dried (MgS04), filtered and concentrated in vacuo. Column chromatography of the residue using stepwise gradient elution (ethyl acetate in hexane 0-5percent) gave the pyrazine derivative as an oil (5.4 g, 68percent). A mixture of the pyrazine derivative (5.4 g, 18.5 mmol) in acetonitrile (55 mL), water (45 mL) and 1 M aqueous hydrochloric acid (45 mL) was stirred at room temperature for 2 h, then concentrated in vacuo to approximately half the volume. Aqueous NaHCO3 (1 M) was added until just alkaline, then the reaction was extracted with dichloromethane (3 x 50 mL). The extracts were dried (MgSO4), filtered and concentrated in vacuo onto silica. Column chromatography of the residue using stepwise gradient elution (ethyl acetate in hexane and triethylamine (0.5percent) 20-100percent) gave pure fractions of (8) which were concentrated in vacuo to a syrup (2.14 g, 58percent). Additional material could be obtained by repeated chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, its application will become more common.

Reference:
Patent; MEDIVIR UK LTD; PEPTIMMUNE, INC; WO2005/82876; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109838-85-9, Computed Properties of C9H16N2O2

Step C – Synthesis of Intermediate Compound Int-7c To a solution of (i?)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (6.16 g, 33.4 mmol) in THF (60 mL) was added TBAI (617 mg, 1.67 mmol). The mixture was cooled to -78 °C and a solution of n-BuLi (14.7 mL, 2.5M in hexanes, 36.75 mmol) was slowly added over 10 minutes. The reaction mixture was allowed to stir at -78 °C for 30 minutes, then Int-7b in THF (20 mL) was slowly added over 10 minutes. The reaction was allowed to stir at -78 °C for 2 hours then allowed to warmed to room temperature and stirred for about 15 hours. The reaction was quenched by addition of MeOH (5 mL), concentrated in vacuo, water added (50 mL) followed by diethyl ether (50 mL) and the layers were separated. The organic layer was washed with water (2 chi 50 mL) then dried over Na2S04, filtered and concentrated in vacuo to provide the crude product. Further purification by column chromatograpy on a 330 g ISCO Redi-Sep silica gel column using a eluent of CH2C12 with a gradient of 0-10percent EtOAc/hexanes afforded the desired product Int-7c as a light amber oil (8.65 g, 63percent). 1H NMR (CDC13) delta 4.07-3.99 (m, 1H), 3.94- 3.89 (m, 1H), 3.79-3.71 (m, 2H), 3.68-3.63 (m, 6H), 2.32-2.17 (m, 1H), 1.25-1.21 (m, 1H), 1.06-0.95 (m, 5H), 0.88 (s, 10H), 0.74-0.68 (m, 1H), 0.69-0.66 (m, 2H), 0.12-0.02 (m, 12H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DWYER, Michael, P.; KEERTIKAR, Kartik, M.; ZENG, Qingbei; MAZZOLA, Robert, D., Jr.; CALDWELL, John, P.; TANG, Haiqun; NAIR, Anilkumar Gopinadhan; SHANKAR, Bandarpalle, B.; ROSENBLUM, Stuart, B.; KOZLOWSKI, Joseph, A.; WO2013/39878; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 109838-85-9

A flame-dried 100-mL round bottom flask was charged with (R)-2,5-dihydro-3,6- dimethoxy-2-isopropylpyrazine (14) (2.4080 g, 13.07 mmol) and THF (20 mt_), andI O evacuated and refilled with N2. The mixture was cooled with a dry ice-acetone bath and 2.5 M n-BuLi in hexanes (5.2 mL, 13.00 mmol) was added dropwise over 15 min. After an additional 0.5 h, a solution of 2-(3-methoxypropoxy)-4-((R)-2-(iodomethyl)-3-methylbutyl)-1- methoxybenzene (8) (3.3023 g, 8.13 mmol, 0.62 equiv) from Example 1 Step 7 in THF (20 mL) was added dropwise via cannula over 10 min. The reaction mixture was allowed to stir15 at -78°C for 16 h and quenched with brine (20 mL) at -78°C. After warming to rt, the mixture was extracted three times with ethyl acetate. The organic phase was dried over Na2SO4, filtered and concentrated in vacuo. The crude (2S,5R)-2-((S)-2-(3-(3-methoxypropoxy)-4- methoxybenzyl)-3-methylbutyl)-2,5-dihydro-5-isopropyl-3,6-dimethoxypyrazine (15) (4.85 g, 80percent) was carried on to the next step without further purification. LC-MS (3 min) tR = 2.41 0 min m/z 463 (M+H+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; WO2007/123718; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, molecular formula is C9H16N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

To a 500 mL flame dried flask was added (i?)-2-isopropyl-3, 6- dimethoxy-2,5-dihydropyrazine (10.0 g, 54.3 mmol) and anhydrous THF (200 mL). The solution was cooled to -78 °C. “-BuLi (2.5M in hexane, 24.0 mL, 59.7 mmol) was added dropwise. After the solution was allowed to stir at -78 °C for 30 minutes, Compound Int-16b (in 5 mL anhydrous THF) was added dropwise. After the solution was allowed to stir at -78 °C for 1 hour, it was allowed to warm up to room temperature in two hours. Water (100 mL) and Et20 (150 mL) were added. The organic layer was separated and the aqueous layer was extracted with Et20 (100 mL) twice. The organic layers were combined, washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue obtained was purified using Si02 chromatography (40 g, eluted with Et20 in Hexane: 0percent to 3percent) to provide Compound Int-16c (10.43 g, 58.0percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109838-85-9, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KOZLOWSKI, Joseph A.; ROSENBLUM, Stuart B.; COBURN, Craig A.; SHANKAR, Bandarpalle, B.; ANILKUMAR, G., Nair; CHEN, Lei; DWYER, Michael, P.; JIANG, Yueheng; KEERTIKAR, Kartik, M.; LAVEY, Brian, J.; SELYUTIN, Oleg, B.; TONG, Ling; WONG, Michael; YANG, De-Yi; YU, Wensheng; ZHOU, Guowei; WU, Hao; HU, Bin; ZHONG, Bin; SUN, Fei; JI, Tao; SHEN, Changmao; RIZVI, Razia; ZENG, Qingbei; WO2012/41014; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 109838-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Step A – Preparation of Compound Int- 13cA 5 L- 3 necked round bottomed flask, equipped with a mechanical stirrer, temperature probe, addition funnel and N2 inlet, was charged with the Schollkopf chiral auxiliary-(Int-13a, 200 g, 1.09 mol, 1.0 eq), bis(chloromethyl) dimethylsilane (Int-13b, 256 g, 1.63 mol, 1.5 eq), and THF (2 L, Aldrich anhydrous). The flask was cooled in a dry ice/ 2- propanol bath until the internal temperature reached -75 °C. n-Butyllithium (Aldrich 2.5 M in hexanes , 478 mL, 1.19 mol, 1.09 eq) was added via a dropping funnel over 1 hour while maintaining the internal reaction temperature between -67 °C and -76 °C. The resulting orange-red solution was allowed to gradually warm to room temperature for about 15 hours. The reaction mixture was then re-cooled to 0 °C and quenched with 500 mL of water.Diethyl ether (2L) was added and the layers were separated. The aqueous layer was extracted with 1 L of diethyl ether. The combined organic layers was washed with water and brine, dried with MgS04, filtered, and concentrated in vacuo to dryness, giving 480 g of orange oil. This material was left in vacuo for about 15 hours to provide 420 g of oil. The crude product was split into two batches and purified via silica gel chromatography on a 1.6 kg flash column. The column was eluted with gradient of 0-4percent Et20 in hexanes. The product fractions were concentrated in vacuo at a bath temperature at or below 40 °C giving 190 grams of Int-13c-(60percentyield).

The synthetic route of (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DWYER, Michael P; KEERTIKAR, Kartik M; COBURN, Craig A; WU, Hao; HU, Bin; ZHONG, Bin; ZHANG, Chengren; DAN, Zhigang; TONG, Ling; YU, Wensheng; WO2012/41227; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 109838-85-9, A common heterocyclic compound, 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, molecular formula is C9H16N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of (2R)-(-)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine(0.61 g, 4.36 mmol) in THF (8 mL) was added n-BuLi (2.5 M in hexane, 1.8 mL, 4.58 mmol) at -78 °C. After allowed to stir for 0.3 hours, Compound Int-15a (2.75 g, 6.98 mmol) in 2 mL of THF was added and the mixture was allowed to stir at the temperature for 4 hours. The reaction was quenched by saturated aqueous H4C1 solution and the organic layers were extracted with EtOAc. The combined organic solution was washed with brine solution, dried (Na2S04), and concentrated in vacuo. The residue obtained was purified using an ISCO 40 g column (gradient from 0percent to 2.5percent ether in hexane) to provide Compound Int-15b, 783 mg (44percent). 1H MR (CDC13) delta 4.05 (m, 1H), 3.96 (t, J= 3.4 Hz, 1H), 3.72 (s, 3H), 3.71 (s, 3H), 3.49 (dd, J= 2,8, 0.4 Hz, 1H), 3.26 (dd, J= 6, 9.4 Hz, 1H), 2.30 (m, 1H), 1.96 (m, 1H), 1.60 (m, 2H), 1.37-1.17 (m, 3H), 1.08 (d, J= 6.9 Hz, 3H), 0.99-0.86 (m, 2H), 0.72 (d, J= 6.6 Hz, 3H), 0.49 (dd, J= 11.0, 14.4 Hz, 1H), 0.35 (dd, J= 11.0, 14.2 Hz, 1H), 0.16 (s, 6H)

The synthetic route of 109838-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KOZLOWSKI, Joseph, A; ROSENBLUM, Stuart, B; COBURN, Craig, A; SHANKAR, Bandarpalle, B; ANILKUMAR, G, Nair; CHEN, Lei; DWYER, Michael, P; JIANG, Yueheng; KEERTIKAR, Kartik, M; LAVEY, Brian, J; SELYUTIN, Oleg, B; TONG, Ling; WONG, Michael; YANG, De-Yi; YU, Wensheng; ZHOU, Guowei; WU, Hao; HU, Bin; ZHONG, Bin; SUN, Fei; JI, Tao; SHEN, Changmao; WO2012/40923; (2012); A1;; ; Patent; SCHERING CORPORATION; COBURN, Craig, A.; LAVEY, Brian, J.; DWYER, Michael, P.; KOZLOWSKI, Joseph, A.; ROSENBLUM, Stuart, B.; WO2012/50848; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 109838-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

2,5-Dihydro-3,6-dimethoxy-2-isopropyl-5-(2′-iodo-4\5′-dibenzyloxybenzyl)- (2R,5S)-pyrazine (32); The diastereomeric product 32 was obtained by a reaction of the lithium salt of the chiral auxiliary (2R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine with the bromo derivative 30 using a modification of a procedure reported in the literature [U. Schollkopf, “Enantioselective Synthesis of Non-Proteinogenic Amino Acids via Metallated Bis-Lactim Ethers of 2,5-Diketopiperazines.” Tetrahedron. 39, pp 2085-2091 (1983)]. Specifically, (2R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine (15.7 mmol) was dissolved in 10 mL of THF (freshly distilled from LiAlH4). The light yellow solution was cooled to -78° C (dry ice/acetone bath) and stirred for 15 min under argon. A 2.5 M solution of n-butyl lithium (15.7 mmol) was added drop wise over a period of 10 min and the mixture was stirred for 20 min at -78° C. In a separate flask CuCN (7.86 mmol) was stirred with 10 mL of freshly distilled THF at room temperature for 10 min. The white suspension was then cooled to 0° C (ice bath) and stirred at that temperature for 20 min. The n-BuLi reaction mixture was then transferred to the white suspension of CuCN/THF under argon using a cannula. The resulting yellow suspension turned into a yellow solution within two minutes. The reaction mixture was then stirred at 0° C for 15 min and cooled to -78° C. After 15 min of stirring at -78° C, a solution of bromo derivative 30 (7.86 mmol) in 20 mL of freshly distilled THF was added drop wise. The color of the reaction mixture changed to greenish brown. After stirring for a further period of 2 h at – 78° C, the reaction mixture was warmed gradually to room temperature. The reaction mixture was then poured into a saturated solution of NH4Cl and extracted with EtOAc. The organic phase was dried over anhydrous Na2SO4, filtered and evaporated to afford an oily compound which was purified by silica gel flash column chromatography eluting with 5 percent ethyl acetate in hexane to yield pure 2,5-dihydro-3,6-dimethoxy-2-isopropyl-5- (2′-iodo-4′,5′-dibenzyloxybenzyl)-(2R,5S)-pyrazine (32) as a white solid in 70percent yield.

The synthetic route of (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; SATYAMURTHY, Nagichettiar; BARRIO, Jorge, R.; WO2010/117435; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, molecular formula is C9H16N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H16N2O2

General procedure: n-Butyllithum (500 muL, 1.6 M in hexane) was added dropwise to a stirred solution of (2R)-2,5 -dihydro-2-isopropyl-3,6-dimethoxypyrazine( 150 jiL, 0.83 mmol) in 3 mL dry THF at -78°C under argon atmosphere. The resultant mixture was allowed to be stirred for additional 5 mm. The obtained yellow solution was subsequently transferred via a double-tipped needle to stirred slurry of copper (I) cyanide (38 mg, 0.42 mmol) in 2 mL THF at -78°C under argon. This mixture was stirred at 0 °C for around 1.5 mm to afford cyanocuprate as a tan colored solution. The reaction was then immediately cooled down to-78 °C. A solution of the iodide 6 (0.28 mmol) in 10 mL dry THF was then added dropwise. The reaction mixture was stirred at -78 °C for 30 mm and then for 16 h at -25 °C under argon. The reaction was quenched by adding a 1:9 mixture of aqueous ammonia/saturated aqueous ammonium chloride (15 mL). The aqueous phase was further extracted with diethyl ether (3 x20 mL). The organic layer was combined and then washed with the 1:9 mixtures of concentrated aqueous ammonia/saturated aqueous ammonium chloride, followed by brine, and then dried with anhydrous Na2SO4. After removing the volatile components with rotavapor, the crude product was purified by silica gel flash chromatography (hexane:EtOAc = 4:1 then 3:1) afforded the desired product 7 as colorless oil. [0066] 7b R = Et, 79percent yield. [CL]D179 +6.75(c 1.01, CHC13); 1H-NMR (600 MHz, DMSO-d6,64°C): delta 0.65(d, 3H,J= 6.8 Hz), 0.99(d, 3H,J= 6.8 Hz), 1.10(t, 3H,J= 7.0 Hz), 1.25(s,3H), 1.37(s, 3H), 1.45-1.48(m, 1H), 1.50-1.60(m, 3H), 1.71-1.75(m, 1H), 1.82-1.85(m, 1H),2.15-2.20(m, 1H), 3.14-3.19(m, 2H), 3.25(s, 3H), 3.60(s, 3H), 3.61(s, 3H), 3.89(t, 1H, J 3.6Hz), 3.98(dd, 1H, J= 10.8Hz, 4.0 Hz), 3.99-4.01(m, 2H), 4.53(d, 1H, J 5.9 Hz), 4.55(d, 1H,J= 5.9 Hz), 4.86(s, 1H), 5.09(s, 2H), 7.30-7.31(m, 1H), 7.33-7.36(m, 4H); 13C-NMR (150MHz, DMSO-d6 rotamers): delta 14.20, 15.17, 16.38, 19.01, 24.64, 26.23, 27.90, 30.73, 31.03,37.52, 37.88, 52.07, 53.83, 54.03, 54.27, 59.77, 65.81, 66.13, 83.29, 83.41, 83.66, 83.70,84.90, 109.05, 109.22, 111.32, 127.22, 127.60, 127.68, 128.21, 128.36, 136.97, 137.26,155.52, 162.76, 163.03, 163.11; MS(ESI) mlz: 590 [M+H] HRMS: calculated forC31H48N308 ([M+H]+) 590.3441, found 590.3440.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109838-85-9, its application will become more common.

Reference:
Patent; MEMORIAL SLOAN-KETTERING CANCER CENTER; ZHENG, Weihong; LUO, Minkui; IBANEZ SANCHEZ, Glorymar del Valle; WO2013/63417; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 109838-85-9

To (R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine (2 mL, 11.03 mmol) in THF (90 mL) at -78 °C was added n-BuLi (1.6 M in hexanes solution, 7.5 mL, 12 mmol). After stirring for 30 min, l-bromo-3-(bromomethyl)-5-fluorobenzene (2.68 g, 10 mmol) in THF (10 mL) was added dropwise over 30 min. The temperature was maintained at -78 °C for 30 min then allowed to warm to ambient temperature. After stirring for 16 h, saturated aqueous NH4C1 (30 mL) was added followed by dilution with EtOAc and H20. The THF was removed in vacuo and the remaining organics were separated and dried over sodium sulfate. After removal of solvent, thecrude product was purified by silica gel chromatography to provide (2S,5R)-2-(3-bromo-5- fluorobenzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (3.17 g, 77percent). MS (m/z) 371 [M+H]+

The synthetic route of 109838-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GILEAD SCIENCES, INC.; BONDY, Steven, S.; CANNIZZARO, Carina, E.; CHOU, Chien-Hung; HU, Yunfeng, Eric; LINK, John, O.; LIU, Qi; SCHROEDER, Scott, D.; TSE, Winston, C.; ZHANG, Jennifer, R.; WO2014/110296; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem