Category: 109-08-0

Synthetic Route of 109-08-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109-08-0 as follows.

EXAMPLE 21; 3-(3,4-Dimethyl-lH-indol-l-yl)-N’-(3-methoxy-4-(pyrazin-2- ylmethoxy)benzylidene)propanehydrazide; [0533] (a) 2-(Chloromethyl)pyrazine: A solution of 2-methylpyrazine (0.75 mL, 8.0 mmol), NCS (1.5 g, 11.4 mmol) and benzoyl peroxide (96 mg, 0.4 mmol) in CCl4 (30 mL) was refluxed overnight. After cooling to room temperature, the reaction was diluted with EtOAc, washed with water, brine and dried (Na2SO4). The crude material obtained (-600 mg) was used directly in the next step

According to the analysis of related databases, 109-08-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; STEIN, Philip; DAINES, Robert; SPROUS, Dennis; O’GRADY, Harold; WO2010/132615; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109-08-0, name is 2-Methylpyrazine, A new synthetic method of this compound is introduced below., Formula: C5H6N2

(E)-2-[2-(Pyrazin-2-yl)vinyl)benzamide hydrochloride n-Butyl lithium (2.5 M in hexanes, 4.8 mL, 12.0 mmol, 1.2 eq.) was added dropwise to a solution of diisopropylamine (1.83 mL, 1.32 g, 13.0 mmol, 1.3 eq.) in dry tetrahydrofuran (25 mL) at -78¡ã C. The mixture was stirred at -78¡ã C. for 10 min and 2-methylpyrazine (0.91 mL, 0.94 g, 10.0 mmol, 1.0 eq.) was added dropwise. The resulting mixture was stirred at -78¡ã C. for 30 min. A solution of 2-cyanobenzaldehyde (1.31 g, 10.0 mmol, 1.0 eq.) in dry THF (10 mL) was added dropwise and the mixture was allowed to slowly warm up to room temperature over 2 h while stirring. The reaction was quenched by addition of water (20 mL). The pH was adjusted to ?10 by careful addition of conc. HCl and the mixture was extracted with dichloromethane (3*25 mL). The combined organic extracts were washed with brine (25 mL), dried over sodium sulfate and evaporated in vacuo. The crude product was purified by column chromatography (SiO2, 1:9 methanol-ethyl acetate) providing 2-(1-hydroxy-2-(pyrazin-2-yl)ethyl)benzamide (1.06 g, 44percent yield) as a clear yellow oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; UNIVERSITY COLLEGE DUBLIN – NATIONAL UNIVERSITY OF IRELAND, DUBLIN; THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH; KENNEDY, Breandan; REYNOLDS, Alison; O’SULLIVAN, Jacintha; BAXTER, Andrew Douglas; (44 pag.)US2016/326122; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 109-08-0, The chemical industry reduces the impact on the environment during synthesis 109-08-0, name is 2-Methylpyrazine, I believe this compound will play a more active role in future production and life.

A solution of lithium diisopropylamine [prepared from a solution of butyl lithium in hexanes (100 mL, 2.5M) and diispropylamine (25.3 g) at -35¡ã C.] was treated with a solution of 2-methylpyrazine (23.5 g) in dry tetrahydrofuran (300 mL) at -20¡ã C. The mixture was stirred at -20¡ã C. for 1 hour then cooled to -78¡ã C. and treated with a solution of allyl bromide (30.8 g) in dry tetrahydrofuran (300 mL). This mixture was warned to room temperature and stirred at this temperature for 2 hours then left overnight and then treated with saturated ammonium chloride solution (50 mL) followed by water (200 mL). The mixture was then extracted twice with ether (200 mL). The combined extracts were dried over magnesium sulfate then evaporated. The residue was distilled to give the title compound (22 g) as a colorless oil, b.p. 70¡ã C./1 mm Hg.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cox, Paul J.; Majid, Tahir N.; Lai, Justine Y.Q.; Morley, Andrew D.; Amendola, Shelley; Deprets, Stephanie D.; Edlin, Christopher; US2004/9983; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-08-0, name is 2-Methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 109-08-0

A 2.5 M hexanes solution of n-BuLi (18.0 mL, 45 mmol) was added to a -78 0C THF solution (60 mL) of t-BuOK (5.1 g, 45 mmol) and diisopropylamine (6.3 mL, 45 mmol). After 5 min at -78 0C the yellow mixture was warmed to -40 0C. Neat methylpyrazine (2.7 mL, 30 mmol) was added and the mixture rapidly turned dark red. After 30 min at – 40 0C the mixture was cooled to -78 0C and neat allyl bromide (7.6 mL, 90 mmol) was added. After 30 min at -78 0C water was added and the mixture was partially concentrated to remove volatile organics. The resulting mixture was extracted with dichloromethane and the combined organics were dried (Na2SO4), concentrated, and purified via column chromatography to give 2.2 g of 2-but-3-enyl-pyrazine.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-08-0.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARBAY, J., Kent; LEONARD, Kristi; CHAKRAVARTY, Devraj; SHOOK, Brian, Christopher; WANG, Aihua; WO2010/45015; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 109-08-0

EXAMPLE 13 4-(2-Pyrazinyl)-1-butene (1300) To a mixture of 15.6 g of sodium amide in 400 ml of ammonia was added dropwise 37.6 g of 2-methylpyrazine. The mixture was stirred for 2 hours and then 24.2 g of allyl bromide in 50 ml of ether was slowly added. This was stirred for 2 hours, 25 g of ammonium chloride added and the ammonia replaced by 500 ml of ether. 250 ml of water was added, the organic layer separated and the aqueous layer extracted twice with ether. The combined organic layers were then concentrated at reduced pressure. The residue was fractionated by distillation to give 20.5 g of product (1300), b.p. 96¡ã-7¡ã (25 mm). UV 2percent EtOH max: 268 (3.82), 273 (3.82). From the above distillation was also obtained 5.4 g of a second product, characterized as the bisalkylated compound, 4-(2-pyrazinyl)-1,6-beptadiene (1301), b.p. 122¡ã-3¡ã (24 mm). UV 10percent EtOH max: 269 (3.83), 273 (3.83).

The synthetic route of 2-Methylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Coca-Cola Company; US4638005; (1987); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 109-08-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-08-0, name is 2-Methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Under an argon gas flow, diisopropylamine (7.70 g) was dissolved in tetrahydrofuran (50 ml), followed by stirring at -78C. A solution of 1.52 M n-butyl lithium in hexane (50 ml) was slowly added dropwise. After the dropwise addition, the mixture was slowly returned to room temperature over 30 minutes and cooled to -78C again to prepare lithium diisopropylamide. To this was added 2-methylpyrazine (4.29 g), the solution was stirred at 0C for 30 minutes and benzonitrile (4.7 g) was slowly added dropwise so that the inner temperature does not exceed 15C. After stirring at 0C for 90 minutes, lithium diisopropylamide was added dropwise, followed by stirring at 40C for 3 hours. The reaction solution was mixed with ice water, extracted with chloroform, washed with saturated brine, dried and then concentrated. The residue was purified by silica gel column chromatography (chloroform:n-hexane = 20:1) to obtain the objective product (2.2 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nippon Shinyaku Co., Ltd.; EP1452525; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-08-0, name is 2-Methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 109-08-0

General procedure: 2-aminophenyl ketones 1 (0.3 mmol), methylazaarenes 2 (0.6 mmol), NH4OAc (0.6 mmol), CuCl2 (20 mol %), TFA (50 mol %), DMF (2.0 mL) were added to a 25mL Schlenk tube under O2 atmosphere with magnetic stirrer bar. The reaction mixture was stirred at 120 _C (oil bath temperature) for 24 h. After the reaction was finished (monitored by TLC), the mixture was cooled to room temperature, quenched with solution of NaHCO3 (10 mL) and extracted with EtOAc (3 _ 10 mL). The combined organic layers were dried over anhydrous MgSO4 and the solvent was removed under vacuum. The crude product was purified by column chromatography (EtOAc/hexanes) on silica gel.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-08-0.

Reference:
Article; Liang, En; Wu, Yinrong; Chen, Jiewen; Xiong, Wei; Zhao, Jinwu; Yao, Xingang; Tang, Xiaodong; Tetrahedron; vol. 75; 52; (2019);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2.0 g methylpyrazine and 1.8g trichloro isocyanuric acid in 30 ml chloroform was refluxed for 18 hours. The resulting solids were filtered off and the solvent evaporated. The residue was dissolved in 7 ml DMF, 160 mg (0.62 mmol) of triazinone (see example 38) and 1 ml DBU were added and stirred for 18 hours. The crude product was purified after20 evaporation of the solvent, using flash chromatography (50 g silica gel, ethyl acetate:chloroform 85/15). The product fractions were combined and the solvent removed under vacuum. The product was crystallized from chloroform: ethyl acetate to give 130 mg of a white solid with the following properties: MP: 229-2310C; 1H NMR (300 MHz, CDCl3) delta 8.79 (IH, s) 8.71 (IH, s), 8.51 (2H, s), 7.85 (IH, s), 5.78 (2H, s), 5.61 (IH, t, J = 6.0 Hz),-25 3.97-3.88 (IH, m), 3.74-3.66 (IH, m) and 2.60-1.95 ppm (4H, m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CORTEX PHARMACEUTICALS, INC.; WO2008/85505; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

109-08-0, name is 2-Methylpyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-Methylpyrazine

2-methylpyrazine (0.18 mL, 2.0 mmol), 4-methoxybenzaldehyde (0.24 mL, 2.0 mmol) and 50percent solution of tetrabutylammoniumsulfate in water (0.23 mL, 0.2 mmol) were added to 2 mL 5N NaOH stirring under nitrogen. The reaction was carried on at 105¡ã C. for 48 h. After cooling to r.t., the mixture was extracted with DCM (3¡Á20 mL), and then the oil phase was washed with water and brine, dried over Na2SO4, concentrated via vacuum. The desired compound was obtained via silica gel chromatograph (EA:hexane=1:2). Faint yellow solid in 43percent yield. M.p.:101.4-102.3¡ã C. 1H NMR (400 MHz, CDCl3) delta 8.61 (d, J=1.0 Hz, 1H), 8.51 (s, 1H), 8.37 (d, J=2.3 Hz, 1H), 7.70 (d, J=16.1 Hz, 1H), 7.54 (d, J=8.7 Hz, 2H), 7.02 (d, J=16.1 Hz, 1H), 6.93 (d, J=8.7 Hz, 2H), 3.85 (s, 3H). 13C NMR (101 MHz, CDCl3) delta 160.32, 151.60, 144.21, 143.54, 142.26, 134.70, 128.78, 128.72, 121.74, 114.25, 55.33. Anal. Calcd for C13H12N2O: C, 73.56; H, 5.70; N, 13.20. Found: C, 73.12; H, 5.79; N, 12.30.

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Washington University; Tu, Zhude; Li, Junfeng; Yue, Xuyi; Kotzbauer, Paul; (100 pag.)US2017/189566; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109-08-0, name is 2-Methylpyrazine, A new synthetic method of this compound is introduced below., Computed Properties of C5H6N2

General procedure: Reaction of AgNO3 (33.8 mg, 0.2 mmol), methylpyrazine (mpyz)(19 mg, 0.2 mmol) and isophthalic acid (H2ipa) (33.3 mg, 0.2 mmol) took place in methanol-DMF (DMF = N,N-dimethylformamide) solvents (6 ml, v/v = 1:1) under ultrasonic treatment (160 W, 40 KHz,30 min) at 50 ¡ãC. Addition of ammonia (25percent, 0.5 mL) was found to be an efficient way to eliminate the white precipitate. The resultant solution was allowed slowly and quietly to evaporate at room temperature. The pale pink and prismatic crystals of compound 1 are obtained after several days in the darkness. The crystals were isolated by filtration and washed by deionized water and enthanol and dried in the air.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Dan-Feng; Wang, Zhan-Hui; Zhang, Ting; Dai, Si-Min; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; vol. 415; (2014); p. 61 – 68;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem