Category: 109-08-0

Related Products of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 500 mL reactor, 94.1 g (1 mol) of 2-methylpyrazine was added.0.2 g (0.0016 mol) of ferrous chloride, and 225 g (1.99 mol) of hydrogen peroxide having a mass concentration of 30percent was added dropwise at 30 ° C.After the completion of the dropwise addition for 4 hours, the temperature was raised to 50 ° C, and 40 g (2.35 mol) of ammonia gas was introduced. After the completion of the ammonia gas, the temperature was maintained for 7 hours.After cooling to 10 ° C, the crude product was filtered.The crude product was recrystallized from 3 times by weight of water to give 117 g of the desired pyrazinamide in a yield of 95percent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-08-0, name is 2-Methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H6N2

(1) Under the protection of nitrogen,A 2-methyl pyrazine in a molar ratio of 1: 0.05: 1.2,Dibenzoyl peroxide and N-chlorosuccinimide were added to the solvent anhydrous carbon tetrachloride, A-chloromethylpyrazine by refluxing;

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-08-0.

Application of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the glove box,Mn(CO)5Br (0.005 mmol),[(E)-2-(2-(1-(2-pyridyl)ethylidene)-indenyl)pyridine] (0.006 mmol),Add 1.0 mL of toluene,After stirring for two hours,Add 2-methylpyrazine 1a (2mmol),Benzyl alcohol 2a (1mmol),After the reaction at 135 C for 48 hours, the reaction was stopped.Evaporate the solvent,Column chromatography ethyl acetate / petroleum ether (1:10),Trans-disubstituted olefin derivative 3a.The product is a white solid.The yield was 81%.

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 109-08-0,Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 1.4.1 (3.0 g, 32 mmol) in CHC13( 100 mL) was heated to reflux and solid Trichloro isocyanuric acid (3.11 g, 13.4 mmol) was added in 4 portions in 1 hour and the reaction was refluxed overnight. The reaction mixture was filtered through celite and washed with IN NaOH, dried and concentrated. The crude 1.4.2 (3.0g) was taken to the next step without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylpyrazine, its application will become more common.

Reference of 109-08-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109-08-0 as follows.

0351] To a solution of LDA (295 mL, 0.59 mol, 2 M in heptane/THF/ethylbenzene) in anhydrous THF (300 mL) cooled to -40 C. was added 2-methylpyrazine (48.5 mL, 0.531 mol) dropwise via an addition funnel. The reaction was allowed to warm to -20 C. and was stirred for 90 minutes when a solution of benzaldehyde (54 mL, 0.531 mol) in anhydrous THF (200 mL) was added dropwise via an addition funnel. After complete addition, the reaction was allowed to warm to room temperature and was stirred for 20 hours. The reaction was then cooled in an ice bath and saturated NH4Cl (500 mL) was added. The resulting mixture was extracted with EtOAc (500 mL, 250 mL). The combined extracts were dried (Na2SO4), filtered and concentrated to a damp, beige solid. The product was triturated with Et2O and collected then dried overnight to yield 56.0 g (53percent) of a light brown solid, mp 81-84 C.

According to the analysis of related databases, 109-08-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hendrix, James A.; Strupczewski, Joseph T.; Bordeau, Kenneth J.; Brooks, Sarah; Hemmerle, Horst; Urmann, Matthias; Zhao, Xu-Yang; Mueller, Paul J.; US2003/229066; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

109-08-0, name is 2-Methylpyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 109-08-0

(1) Dissolve 9.41 g (0.1 mol) of 2-methylpyrazine in 30.0percent of 182.30 g of hydrochloric acid (containing 1.5 mol of hydrogen chloride).Under stirring, the temperature was controlled at 0-15¡ãC, and 25.32 g of a 25.0percent hydrogen peroxide solution was added dropwise.The reaction temperature was controlled at 0-15¡ãC to make the reaction system chlorinated. The reaction was sampled at regular intervals and detected by high performance liquid chromatography.When it was detected that the mass of 2-methyl-3-chloropyrazine in the reaction system accounted for 73.5percent of the total organic matter mass in the reaction system,The reaction was terminated by adding 17.21 g (0.12 mol) of cuprous bromide to obtain a 2-methyl-3-chloropyrazine-containing solution; (2) Add 63.78 g of methylene chloride to the feed solution, stir and extract for 2 hours, and let stand for 1 hour.Take the organic phase and allow it to cool down to -15¡ãC to -5¡ãC to allow solids to be analyzed from the organic phase.8.36 g of the resulting fixative is 2-methyl-3-chloropyrazine,After calculation, the yield was 65.5percent, and the main containment was 97.8percent.

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong Tianxin Chemical Co., Ltd.; Ju Youguo; Zhao Benteng; Wang Zewu; Yang Hanhua; Zhang Zhaoyuan; Liu Jian; Gong Fangxin; (6 pag.)CN107954913; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 109-08-0,Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

S1:30ml of absolute ethanol,0.2mol / L of 2-methylpyrazine and 1.25mol / L of potassium hydroxide solution into 200mL autoclave,Under 1.5MPa oxygen pressure magnetic stirring 1.5h,Then add 5.0 ¡Á 10-5mol / L of the catalyst was added to the reaction,In the magnetic stirring process,200mL autoclave was heated,And the heating temperature is maintained at 120 ;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylpyrazine, its application will become more common.

Reference:
Patent; Henan Engineering College; Zhang Qian; He Li; Li Yue; Chen Lei; Zhao Longtao; (6 pag.)CN106831612; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 109-08-0,Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step a Preparation of n-octyl pyrazine (Compound II in which R=H and n=8) To 15.6 g (0.4 mole) of sodium amide in 400 ml of anhydrous liquid ammonia cooled at -50¡ã C., there were added 37.6 g (0.4 mole) of methyl pyrazine. The mixture was stirred for half an hour at the same temperature. Then, n-heptyl bromide (35.8 g, 0.2 mole), diluted with an equal volume of anhydrous diethyl ether, was added over a 20 minutes period and the mixture was stirred for an additional hour. The reaction was quenched by the addition of 25 g of solid ammonium chloride and the ammonia was replaced by diethyl ether. The mixture was heated until the diethyl ether just started to reflux, and was then poured into ice, rendered strongly acidic by the addition of concentrated HCl and extracted with diethyl ether. The aqueous layer was then rendered basic by the addition of NaOH and extracted with CHCl3. After drying over MgSO4 and filtration, the evaporation of the organic phase led to a residue which was chromatographed on a silica gel column using diethyl ether/petroleum ether (15:85, v:v) as eluent. The title compound II (33.4 g, yield 87percent) was recovered as a pale yellow liquid. IR (film): 3050 (aromatic C-H), 2940, 2860 (C-H), 1580, 1525 (aromatic ring) cm-1. 1 H NMR (60 MHz, CDCl3, HMDS) delta ppm: 8.5 (large s, 3H, aromatic H), 2.75 (t, 2H, CH2 -C=N), 1.7 (m, 2H, CH2 -C-C=N), 1.25 (large s, 10H, (CH2)5), 0.8 (t, 3H, CH3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylpyrazine, its application will become more common.

Reference:
Patent; Societe de Conseils de Recherches et d’Applications Scientifiques (S.C.R.A.S.); US5019576; (1991); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H6N2

Step C??Synthesis of mt 7-3 10347] To a solution of 2-methylpyrazine (272 mg, 2.9 mmol) and HMPA (520 mg, 2.9 mmol) in THF (2.5 mE) was added EDA (1.6 mE, 3 mmol) at ?78¡ã C. dropwise. The mixture was allowed to stir at ?78¡ã C. for 30 minutes before a solution of mt 7-2 (600 mg, 2.45 mmol) in 2 mE of THF was added. The mixture was allowed to warm to room temperature for 3 hours before it was quenched with 10 mE of saturated NH4C1 solution. The resulting mixture was extracted with EtOAc (3×10 mE) and the combined organic washings were dried over sodium sulfate, filtered and in vacuo. The resulting residue was purified using column chromatography (25percent EtOAc/petroleum ether) to provide mt 7-3 (100 mg, 12percent). MS (ESI): mlz (M+H) 339.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109-08-0, its application will become more common.

Reference:
Patent; Coburn, Craig A.; Maletic, Milana; Soll, Richard; Li, Chunsing; Luo, Yunfu; Qi, Zhiqi; US2014/5103; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-08-0, name is 2-Methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Methylpyrazine

Butyllithium (1.6 M in hexane solution, 10 ml, 16 mmol) was added dropwise to a solution of diisopropylamine (2.25 ml, 16 mmol) in anhydrous THF (50 ml) at -20¡ãC under a nitrogen atmosphere. The mixture was stirred at -20¡ãC for 30 minutes and after cooling at -70¡ãC a solution of 2-methyl-pyrazine (1.47 ml, 16 mmol) in THF (10 ml) was added dropwise. After 15 minutes, a solution of 3-bromo-propionic acid ethyl ester (2.54 ml, 19.2 mmol) in THF (10 ml) was added and the mixture maintained at -70¡ãC for 2 hours and then stirred at room temperature overnight. The reaction was then quenched with a saturated solution of NH4Cl and extracted with ethyl acetate, the organic phase was dried (Na2SO4) and evaporated. The residue was purified by flash chromatography (hexane/ ethyl acetate from 9/1 to 1/1 respectively) to give the title compound (1 g, 33percent yield). UPLC/MS: 195.1 (MH+).

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Neurotune AG; EP2098526; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem